Shiguo Zhou received his Ph.D. degree in plant pathology from the University of Wisconsin-Madison, Madison, WI, USA, in fungal molecular systematics under the supervision of Professor Glen R. Stanosz. He conducted his postdoctoral research on physical mapping of the black death pathogen Yersinia pestis and the leishmaniasis pathogen Leishmania major genomes, employing single molecule optical mapping approach in Professor David C. Schwartz's Lab. Currently, Dr. Zhou works as a Senior Research Scientist at the Laboratory of Molecular and Computational Genomics, University of Wisconsin-Madison Biotechnology Center. His research interests are mainly focused on (1) understanding diverse genome structures and organizations, (2) detection of structural alterations among populations or strains, cultivars, or species, associated with diseases, and (3) development of molecular markers for disease diagnosis. During the past few years, Dr. Zhou has successfully mapped the genomes of rice, maize, Medicago, oil palm, castor bean, mouse, rat, potato late blight pathogen Phytophthora infestans, human stem cell and breast cancer, and more than ten fungal species. The single molecular optical restriction maps of these genomes that Dr. Zhou has completed have been used either as physical scaffolds which have significantly improved the accuracy of genome sequence assemblies or as means for genome structural variation detection and complex genotyping, which are complementary to array CGH or next-generation sequencing CNV analysis.
Biography Updated on 30 April 2013