Nicholas Farrell

Articles in Scholarly Journals [Incomplete List]

  1. Differences in the cellular response and signaling pathways of cisplatin and BBR3464 ([{trans-PtCl(NH3)2}2µ-(trans-Pt(NH3)2(H2N(CH2)6-NH2)2)]4+) influenced by copper homeostasis
    Biochemical Pharmacology, vol. 73, no. 9, pp. 1270–1279, 2007
  2. Promotion of DNA strand breaks, interstrand cross-links and apoptotic cell death in A2780 human ovarian cancer cells by transplatinum planar amine complexes
    Biochemical Pharmacology, vol. 73, no. 11, pp. 1749–1757, 2007
  3. 1,2-GG intrastrand cross-link of antitumor dinuclear bifunctional platinum compound with spermidine linker inhibits DNA polymerization more effectively than the cross-link of conventional cisplatin
    Archives of Biochemistry and Biophysics, vol. 459, no. 2, pp. 264–272, 2007
  4. Targeting Retroviral Zn Finger-DNA Interactions: A Small-Molecule Approach Using the Electrophilic Nature of trans-Platinum-Nucleobase Compounds
    Chemistry & Biology, vol. 13, no. 5, pp. 539–548, 2006
  5. Biochemistry, vol. 45, no. 13, pp. 4248–4256, 2006
  6. Inorganic Chemistry, vol. 45, no. 4, pp. 1638–1645, 2006
  7. Inorganic Chemistry, vol. 45, no. 15, pp. 5733–5735, 2006
  8. Journal of the American Chemical Society, vol. 128, no. 50, pp. 16092–16103, 2006
  9. Journal of Medicinal Chemistry, vol. 49, no. 1, pp. 224–231, 2006
  10. Deoxyribonuclease I footprinting reveals different DNA binding modes of bifunctional platinum complexes
    FEBS Journal, vol. 273, no. 15, pp. 3467–3478, 2006
  11. Polynuclear platinum anticancer drugs are more potent than cisplatin and induce cell cycle arrest in glioma
    Neuro-Oncology, vol. 8, no. 3, pp. 215–226, 2006
  12. Biological Consequences of Trinuclear Platinum Complexes: Comparison of [ 2 -(trans-Pt(NH3)2(H2N(CH2)6-NH2)2)]4+ (BBR 3464) with Its Noncovalent Congeners
    Molecular Pharmacology, vol. 69, no. 2, pp. 666–672, 2005
  13. Journal of Medicinal Chemistry, vol. 48, no. 18, pp. 5651–5654, 2005
  14. Thiolate-bridged heterodinuclear platinum–zinc chelates as models for ternary platinum–DNA–protein complexes and zinc ejection from zinc fingers. Evidence from studies using ESI-mass spectrometry
    Chemical Communications, no. 34, p. 4360, 2005
  15. Analysis of Glioma Cell Platinum Response by Metacomparison of Two-dimensional Chromatographic Proteome Profiles
    Molecular & Cellular Proteomics, vol. 5, no. 1, pp. 35–42, 2005
  16. Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of Antitumor trans-[PtCl2(NH3)(thiazole)]
    Nucleic Acids Research, vol. 33, no. 18, pp. 5819–5828, 2005
  17. Inorganic Chemistry, vol. 44, no. 5, pp. 1196–1198, 2005
  18. Inorganic Chemistry, vol. 44, no. 3, pp. 483–485, 2005
  19. Inorganic Chemistry, vol. 44, no. 15, pp. 5247–5253, 2005
  20. Inorganic Chemistry, vol. 44, no. 9, pp. 3004–3006, 2005
  21. Inorganic Chemistry, vol. 44, no. 26, pp. 9598–9600, 2005
  22. Biochemistry, vol. 44, no. 31, pp. 10620–10634, 2005
  23. Identification of non-cross-resistant platinum compounds with novel cytotoxicity profiles using the NCI anticancer drug screen and clustered image map visualizations
    Critical Reviews in Oncology/Hematology, vol. 53, no. 1, pp. 25–34, 2005
  24. Platinum coordination compounds in cancer chemotherapy
    Critical Reviews in Oncology/Hematology, vol. 53, no. 1, pp. 1–2, 2005
  25. Effects of geometric isomerism in dinuclear antitumor platinum complexes on their interactions with N-acetyl-L-methionine
    JBIC Journal of Biological Inorganic Chemistry, vol. 10, no. 5, pp. 433–442, 2005
  26. Effects of geometric isomerism in dinuclear platinum antitumor complexes on aquation reactions in the presence of perchlorate, acetate and phosphate
    JBIC Journal of Biological Inorganic Chemistry, vol. 10, no. 6, pp. 652–666, 2005
  27. Effects of geometric isomerism in dinuclear antitumor platinum complexes on their interactions with N-acetyl-L-methionine
    JBIC Journal of Biological Inorganic Chemistry, vol. 10, no. 7, pp. 827–827, 2005
  28. Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding
    Journal of Inorganic Biochemistry, vol. 98, no. 10, pp. 1560–1569, 2004
  29. Comparison of structural effects in 1,4 DNA?DNA interstrand cross-links formed by dinuclear and trinuclear platinum complexes
    Journal of Inorganic Biochemistry, vol. 98, no. 10, pp. 1585–1590, 2004
  30. Synthesis and DNA conformational changes of non-covalent polynuclear platinum complexes
    Journal of Inorganic Biochemistry, vol. 98, no. 10, pp. 1591–1598, 2004
  31. Cytotoxicity, DNA strand breakage and DNA?protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells
    Biochemical Pharmacology, vol. 68, no. 5, pp. 857–866, 2004
  32. The Ninth International Symposium on Platinum Compounds in Cancer Chemotherapy
    Journal of Inorganic Biochemistry, vol. 98, no. 10, pp. v–v, 2004
  33. Biochemistry, vol. 43, no. 24, pp. 7776–7786, 2004
  34. Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin
    Nucleic Acids Research, vol. 32, no. 18, pp. 5546–5552, 2004
  35. Preclinical perspectives on the use of platinum compounds in cancer chemotherapy
    Seminars in Oncology, vol. 31, pp. 1–9, 2004
  36. Journal of the American Chemical Society, vol. 126, no. 7, pp. 2166–2180, 2004
  37. DNA Binding by Antitumor trans-[PtCl2(NH3)(thiazole)]. Protein Recognition and Nucleotide Excision Repair of Monofunctional Adducts
    Biochemistry, vol. 42, no. 3, pp. 792–800, 2003
  38. Inorganic Chemistry, vol. 42, no. 18, pp. 5498–5506, 2003
  39. Competitive Reactions of Interstrand and Intrastrand DNA-Pt Adducts: A Dinuclear-Platinum Complex Preferentially Forms a 1,4-Interstrand Cross-Link Rather than a 1,2 Intrastrand Cross-link on Binding to a GG 14-Mer Duplex
    Chemistry - A European Journal, vol. 9, no. 3, pp. 713–725, 2003
  40. Cooperative effects in long-range 1,4 DNA-DNA interstrand cross-links formed by polynuclear platinum complexes: an unexpected syn orientation of adenine bases outside the binding sites
    Journal of Biological Inorganic Chemistry, vol. 8, no. 1-2, pp. 19–28, 2003
  41. A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464
    Journal of Biological Inorganic Chemistry, vol. 7, no. 4-5, pp. 397–404, 2002
  42. Biomedical uses and applications of inorganic chemistry. An overview
    Coordination Chemistry Reviews, vol. 232, no. 1-2, pp. 1–4, 2002
  43. Inorganic Chemistry, vol. 41, no. 5, pp. 1101–1109, 2002
  44. Circular dichroism study of the irreversibility of conformational changes induced by polyamine-linked dinuclear platinum compounds
    Journal of Inorganic Biochemistry, vol. 91, no. 1, pp. 212–219, 2002
  45. The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drugElectronic supplementary information (ESI) available: experimental conditions for the NMR reactions, the models used for the kinetic fits and [1H,15N] HSQC NMR spectra of the final products from reactions of 1 with the single strand (I) (before and after addition of the complementary strand (II)), and with the duplex (III). See http://www.rsc.org/suppdata/cc/b2/b209661g/
    Chemical Communications, no. 1, pp. 122–123, 2002
  46. DNA Interstrand Cross-links of the Novel Antitumor Trinuclear Platinum Complex BBR3464. CONFORMATION, RECOGNITION BY HIGH MOBILITY GROUP DOMAIN PROTEINS, AND NUCLEOTIDE EXCISION REPAIR
    Journal of Biological Chemistry, vol. 277, no. 50, pp. 48076–48086, 2002
  47. Conformation, Recognition by High Mobility Group Domain Proteins, and Nucleotide Excision Repair of DNA Intrastrand Cross-links of Novel Antitumor Trinuclear Platinum Complex BBR3464
    Journal of Biological Chemistry, vol. 276, no. 25, pp. 22191–22199, 2001
  48. Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex
    Nucleic Acids Research, vol. 29, no. 10, pp. 2034–2040, 2001
  49. Journal of the American Chemical Society, vol. 123, no. 23, pp. 5576–5577, 2001
  50. Kinetic Analysis of the Stepwise Formation of a Long-Range DNA Interstrand Cross-link by a Dinuclear Platinum Antitumor Complex: Evidence for Aquated Intermediates and Formation of Both Kinetically and Thermodynamically Controlled Conformers
    Journal of the American Chemical Society, vol. 123, no. 7, pp. 1316–1326, 2001
  51. Inorganic Chemistry, vol. 40, no. 8, pp. 1745–1750, 2001
  52. Inorganic Chemistry, vol. 40, no. 24, pp. 6108–6114, 2001
  53. Inorganic Chemistry, vol. 40, no. 24, pp. 6324–6327, 2001
  54. Inorganic Chemistry, vol. 39, no. 16, pp. 3734–3734, 2000
  55. Inorganic Chemistry, vol. 39, no. 13, pp. 2960–2960, 2000
  56. Kinetics and mechanism for reduction of anticancer-active tetrachloroam(m)ine platinum(IV) compounds by glutathione
    Journal of Biological Inorganic Chemistry, vol. 5, no. 3, pp. 300–306, 2000
  57. Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups
    Journal of Biological Inorganic Chemistry, vol. 5, no. 3, pp. 364–368, 2000
  58. Inorganic Chemistry, vol. 39, no. 8, pp. 1710–1715, 2000
  59. Inorganic Chemistry, vol. 39, no. 9, pp. 1882–1890, 2000
  60. Journal of Medicinal Chemistry, vol. 43, no. 16, pp. 3189–3192, 2000
  61. Sequence Specificity, Conformation, and Recognition by HMG1 Protein of Major DNA Interstrand Cross-links of Antitumor Dinuclear Platinum Complexes
    Journal of Biological Chemistry, vol. 275, no. 21, pp. 15789–15798, 2000
  62. A novel charged trinuclear platinum complex effective against cisplatin-resistant tumours: hypersensitivity of p53-mutant human tumour xenografts
    British Journal of Cancer, vol. 80, no. 12, pp. 1912–1919, 1999
  63. Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes
    Journal of Inorganic Biochemistry, vol. 77, no. 1-2, pp. 43–46, 1999
  64. Comparison of cytotoxicity and cellular accumulation of polynuclear platinum complexes in L1210 murine leukemia cell lines
    Journal of Inorganic Biochemistry, vol. 77, no. 1-2, pp. 47–50, 1999
  65. The cellular basis of the efficacy of the trinuclear platinum complex BBR 3464 against cisplatin-resistant cells
    Journal of Inorganic Biochemistry, vol. 77, no. 1-2, pp. 59–64, 1999
  66. Cellular pharmacology of polynuclear platinum anti-cancer agents
    Journal of Inorganic Biochemistry, vol. 77, no. 1-2, pp. 51–57, 1999
  67. Biochemistry, vol. 38, no. 21, pp. 6781–6790, 1999
  68. Biochemistry, vol. 38, no. 34, pp. 10997–11005, 1999
  69. Biochemistry, vol. 38, no. 45, pp. 14731–14737, 1999
  70. Inorganic Chemistry, vol. 37, no. 4, pp. 708–716, 1998
  71. Inorganic Chemistry, vol. 37, no. 4, pp. 717–723, 1998
  72. Investigation of thetrans effect in the fragmentation of dinuclear platinum complexes by electrospray ionization surface-induced dissociation tandem mass spectrometry
    Journal of Mass Spectrometry, vol. 33, no. 5, pp. 436–443, 1998
  73. Structural and reactivity studies on the ternary system guanine/methionine/ trans -[PtCl 2 (NH 3 )L] (L=NH 3 , quinoline): implications for the mechanism of action of nonclassical trans -platinum antitumor complexes
    Journal of Biological Inorganic Chemistry, vol. 3, no. 6, pp. 570–580, 1998
  74. DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]
    European Journal of Biochemistry, vol. 254, no. 3, pp. 547–557, 1998
  75. Effect of geometric isomerism in dinuclear platinum antitumour complexes on the rate of formation and structure of intrastrand adducts with oligonucleotides
    Nucleic Acids Research, vol. 25, no. 6, pp. 1265–1271, 1997
  76. Effects of quinoline as ligand in binding of mononuclear and dinuclear platinum complexes to DNA
    Inorganica Chimica Acta, vol. 255, no. 1, pp. 1–6, 1997
  77. Inorganic Chemistry, vol. 36, no. 17, pp. 3657–3665, 1997
  78. Inorganic Chemistry, vol. 36, no. 18, pp. 3919–3927, 1997
  79. Biochemistry, vol. 35, no. 51, pp. 16705–16713, 1996
  80. Association of mononuclear and dinuclear platinum tetraamine cations with nucleotides studied by 15N NMR relaxation
    Inorganica Chimica Acta, vol. 245, no. 2, pp. 265–267, 1996
  81. A circular dichroism study of ethidium bromide binding to Z-DNA induced by dinuclear platinum complexes
    Journal of Inorganic Biochemistry, vol. 63, no. 1, pp. 9–18, 1996
  82. cis-(R,S)-Bis(benzyl methyl sulfoxide)dichloroplatinum(II)
    Acta Crystallographica Section C Crystal Structure Communications, vol. 52, no. 5, pp. 1091–1093, 1996
  83. Inorganic Chemistry, vol. 35, no. 17, pp. 4865–4872, 1996
  84. Dinuclear Platinum Complexes Form a Novel Intrastrand Adduct with d(GpG), an anti-syn Conformation of the Macrochelate As Observed by NMR and Molecular Modeling
    Journal of the American Chemical Society, vol. 118, no. 39, pp. 9307–9313, 1996
  85. A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA
    Nature Structural Biology, vol. 2, no. 7, Article ID nsb0795-577, 9 pages, 1995
  86. Characterization of cisplatin-glutathione adducts by liquid chromatography-mass spectrometry evidence for their formation in vitro but not in vivo after concomitant administration of cisplatin and glutathione to rats and cancer patients
    Journal of Chromatography B: Biomedical Sciences and Applications, vol. 669, no. 2, pp. 247–263, 1995
  87. Inorganic Chemistry, vol. 34, no. 13, pp. 3573–3576, 1995
  88. Chemical reactivity and DNA sequence specificity of formally monofunctional and bifunctional bis(platinum) complexes
    Journal of Inorganic Biochemistry, vol. 54, no. 3, pp. 207–220, 1994
  89. Synthesis of functionalized platinum complexes containing dimethylsulfoxide as leaving group. Observation of novel steric control of intrastrand versus interstrand cross-linking by use of bulky ligands
    Journal of Inorganic Biochemistry, vol. 55, no. 2, pp. 79–85, 1994
  90. Biochemistry, vol. 33, no. 18, pp. 5404–5410, 1994
  91. Inorganic Chemistry, vol. 32, no. 11, pp. 2591–2593, 1993
  92. Inorganic Chemistry, vol. 31, no. 4, pp. 634–639, 1992
  93. Inorganic Chemistry, vol. 31, no. 5, pp. 930–932, 1992
  94. Journal of Medicinal Chemistry, vol. 35, no. 24, pp. 4526–4532, 1992
  95. The dinuclear complex [{trans-PtCl(NH3)2}2{?-H2N(CH2)6NH2}]Cl2 forms a unique macrochelate intrastrand crosslink with d(GpG)
    Journal of the Chemical Society, Chemical Communications, no. 14, p. 1002, 1992
  96. Journal of the American Chemical Society, vol. 113, no. 13, pp. 4851–4857, 1991
  97. Inorganic Chemistry, vol. 30, no. 24, pp. 4531–4535, 1991
  98. Inorganic Chemistry, vol. 29, no. 3, pp. 397–403, 1990
  99. Biochemistry, vol. 29, no. 41, pp. 9522–9531, 1990
  100. Journal of Medicinal Chemistry, vol. 33, no. 8, pp. 2179–2184, 1990
  101. Journal of Medicinal Chemistry, vol. 32, no. 10, pp. 2240–2241, 1989
  102. Potentiation of Radiation-Induced Bacterial Cell Killing by Binuclear Rhodium(II) Carboxylates
    Radiation Research, vol. 120, no. 3, p. 403, 1989
  103. Inorganic Chemistry, vol. 28, no. 18, pp. 3416–3420, 1989
  104. Journal of the American Chemical Society, vol. 110, no. 15, pp. 5018–5019, 1988
  105. Radiosensitizers targeted to DNA using platinum. Synthesis, characterisation, and DNA binding of cis-[PtCl2(NH3)(nitroimidazole)]
    Journal of the Chemical Society, Chemical Communications, no. 13, p. 1043, 1987
  106. Platinum Complexes with One Radiosensitizing Ligand [PtCl 2 (NH 3 ) (Sensitizer)]: Radiosensitization and Toxicity Studies in Vitro
    Radiation Research, vol. 112, no. 2, p. 273, 1987
  107. Inorganic Chemistry, vol. 26, no. 9, pp. 1426–1429, 1987
  108. Reactions of oxobis(acetylacetonato)- vanadium(IV) with some purine and pyrimidine bases and nucleosides
    Journal of Inorganic Biochemistry, vol. 30, no. 4, pp. 309–315, 1987
  109. Assessment of DNA binding of platinum-radiosensitizer complexes by inhibition of restriction enzymes
    Chemico-Biological Interactions, vol. 62, no. 2, pp. 117–129, 1987
  110. Chromosome-damaging activity of a ruthenium radio-sensitizer, RuCl(DMSO)(4-Nitroimidazole), in Chinese hamster ovary cells in vitro
    Chemico-Biological Interactions, vol. 59, pp. 247–254, 1986
  111. Journal of the American Chemical Society, vol. 107, no. 2, pp. 384–388, 1985
  112. Trypanocidal and antitumour activity of platinum-metal and platinum-metal-drug dual-function complexes
    Biochemical Pharmacology, vol. 33, no. 7, pp. 961–971, 1984
  113. Dimethyl sulphoxide as leaving group: applications in transition metal chemotherapy
    Journal of the Chemical Society, Chemical Communications, no. 6, p. 331, 1982
  114. Inorganic Chemistry, vol. 17, no. 7, pp. 1965–1969, 1978