Sabrina Taliani obtained a degree cum laude in chemistry and pharmaceutical technologies in 1994, at the Faculty of Pharmacy of the University of Pisa; in 1998, Taliani obtained a Ph.D. degree in medicinal chemistry at the Department of Pharmaceutical Science of the University of Pisa. From 1997 to 2001, Taliani held a permanent position “Tecnico Laureato” (Graduated Technician), and since 2001, she has been an Assistant Professor in medicinal chemistry, at the Department of Pharmaceutical Sciences, University of Pisa. Her research interests span in various medicinal chemistry fields. Concerning the central benzodiazepine receptor (BzR) ligands, she has contributed to the definition of new classes of high-affinity ligands, the indolylglyoxylamides (IGAs), the 3-aryltriazinobenzimidazoles, and the 2-phenyltriazolobenzotriazines. In the last few years, she discovered a new class of high-affinity and -selectivity ligands to the peripheral benzodiazepine receptor (PBR or TSPO), the 2-phenylindolglyoxylamides (PIGAs), which were successively conjugated with a fluorescent moiety and/or a chemoreactive group, or radiolabeled with 11C, giving probes that specifically label the TSPO. In the field of adenosine receptors, she has described numerous classes of novel A1 and A3 selective antagonists bearing nonpurine heterocyclic structures. In the field of enzyme inhibitors, she focussed her interests on the development of aldose reductase (ARIs), and adenosine deaminase (ADA) inhibitors. Finally, her research in the antitumoral field led her to study numerous polyheterocyclic molecules showing cytotoxic activity mainly attributable to an intercalative mode of binding to DNA and/or to inhibition of topoisomerase II.
Biography Updated on 31 March 2011