Maurizio Bocchetta graduated in biology in 1991 at the Sapienza University of Rome, Rome, Italy. After a fellowship at the Palo Alto Medical Foundation, Palo Alto, Calif, USA, he received his Ph.D. degree in human molecular biology at the Sapienza University of Rome in 1996. Dr. Bocchetta was a Postdoctoral Fellow at the Department of Medicinal Chemistry of the University of Illinois at Chicago (1996–1998) working under the mentorship of Dr. Alexander S. Mankin. During these years Dr. Bocchetta studied the structure and function of the peptidyl-transferase center of the E. coli large ribosomal subunit. In 1998, he joined the Loyola University Chicago Medical Center as a Research Assistant Professor. Dr. Bocchetta's primary research interest has been the pathogenic role of Simian virus 40 (SV40) in the development of malignant mesothelioma, the mechanisms of DNA viruses-mediated cell transformation, and interaction of the major SV40 oncogenes with primary mesothelial cells' proteins. More recently, Dr. Bocchetta’s laboratory has shifted the focus of its research on hypoxic tumor microenvironment, the role that developmental pathways play for hypoxic tumor cell survival, quiescence, and regulation of metabolism. These investigations are aimed at finding novel therapeutic strategies for the treatment of hypoxic lung cancer and mesothelioma tumor microenvironment. Dr. Bocchetta's findings have been published in high-quality scientific journals, including Proceedings of the National Academy of Sciences, Cancer Research, and Oncogene.
Biography Updated on 14 August 2012