G. Chéron is a neurophysiologist at the ULB. After his PhD thesis dedicated to the human ageing, he characterized several components of the somatosensory evoked potentials, including the spinal N13-P13, which were rapidly used in clinical neurology. J.E. Desmedt and G. Chéron were the first to show the existence of the N30 frontal evoked potential as a specific wave with a traceable evolution during ageing. He then developed gating paradigms and recently revealed the oscillatory mechanism involved in cortical processing of somatosensory information. G. Chéron and E. Godaux have contributed to the first biological identification of the oculomotor neural integrator (NI) in the nucleus prepositus of the cat. The NI is central to gaze stability, it represents a group of neurons that converts vestibular input into eye-position commands. G. Chéron has also contributed to the description of the firing behaviour and the pharmacological properties of the NI, namely the involvement of the NMDA receptors in this neuronal processing. The NI concept has been generalized for a mechanism of working memory in cognitive field. The recent work of G. Chéron, has focussed on the cerebellum. He thus discovered and finely characterized high-frequency oscillation (160 Hz) in Purkinje cell firing in alert mice with abnormalities in calcium homeostasis. He then documented this stereotyped cerebellar functioning in different mouse models of human disorders, such as Angelman syndrome and the fetal alcohol syndrome. G. Chéron has also developed several approaches in translational research and integrative neuroscience (motor control and brain oscillations in human). He is also the principal investigator of the NeuroCog and NeuroSpat space missions carried out in the International Space Station aiming at better understanding EEG rhythms during sensory-motor paradigms. This expertise is currently applied by his group on extraction of pertinent EEG signals for BCI rehabilitation.
Biography Updated on 18 October 2011