Shoukat Dedhar

Personal Home Page

http://www.biochem.ubc.ca/fac_research/faculty/dedhar.html

Articles in Scholarly Journals [Incomplete List]

  1. Loss of integrin linked kinase from mouse hepatocytesin vitro andin vivo results in apoptosis and hepatitis
    Hepatology, vol. 45, no. 4, pp. 1025–1034, 2007
  2. Role of the integrin-linked kinase (ILK) in determining neuronal polarity
    Developmental Biology, vol. 306, no. 2, pp. 457–468, 2007
  3. Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion
    Cellular Microbiology, vol. 9, no. 6, pp. 1519–1528, 2007
  4. Integrin-Linked Kinase at the Heart of Cardiac Contractility, Repair, and Disease
    Circulation Research, vol. 100, no. 10, pp. 1408–1414, 2007
  5. Tubular Epithelial Cell Dedifferentiation Is Driven by the Helix-Loop-Helix Transcriptional Inhibitor Id1
    Journal of the American Society of Nephrology, vol. 18, no. 2, pp. 449–460, 2007
  6. Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium
    AJP: Cell Physiology, vol. 290, no. 6, pp. C1532–C1542, 2006
  7. Preferential Dependence of Breast Cancer Cells versus Normal Cells on Integrin-Linked Kinase for Protein Kinase B/Akt Activation and Cell Survival
    Cancer Research, vol. 66, no. 1, pp. 393–403, 2006
  8. Inhibition of the Phosphatidylinositol 3'-Kinase Pathway Promotes Autocrine Fas-Induced Death of Phosphatase and Tensin Homologue-Deficient Prostate Cancer Cells
    Cancer Research, vol. 66, no. 9, pp. 4781–4788, 2006
  9. Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells
    Molecular Cancer Therapeutics, vol. 5, no. 3, pp. 645–654, 2006
  10. Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma
    Molecular Cancer Therapeutics, vol. 5, no. 4, pp. 833–842, 2006
  11. Novel Role for Integrin-Linked Kinase in Modulation of Coxsackievirus B3 Replication and Virus-Induced Cardiomyocyte Injury
    Circulation Research, vol. 99, no. 4, pp. 354–361, 2006
  12. Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism
    Journal of Cell Science, vol. 119, no. 13, pp. 2787–2796, 2006
  13. Critical Role of Integrin-Linked Kinase in Granule Cell Precursor Proliferation and Cerebellar Development
    Journal of Neuroscience, vol. 26, no. 3, pp. 830–840, 2006
  14. An Essential Role for the Integrin-Linked Kinase-Glycogen Synthase Kinase-3  Pathway during Dendrite Initiation and Growth
    Journal of Neuroscience, vol. 26, no. 51, pp. 13344–13356, 2006
  15. Podocyte-Specific Deletion of Integrin-Linked Kinase Results in Severe Glomerular Basement Membrane Alterations and Progressive Glomerulosclerosis
    Journal of the American Society of Nephrology, vol. 17, no. 5, pp. 1334–1344, 2006
  16. Essential Role of Integrin-Linked Kinase in Podocyte Biology: Bridging the Integrin and Slit Diaphragm Signaling
    Journal of the American Society of Nephrology, vol. 17, no. 8, pp. 2164–2175, 2006
  17. Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure
    Genes & Development, vol. 20, no. 17, pp. 2355–2360, 2006
  18. Integrin-linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells
    Cellular Microbiology, vol. 8, no. 2, pp. 257–266, 2006
  19. The epithelial-mesenchymal transition: new insights in signaling, development, and disease
    The Journal of Cell Biology, vol. 172, no. 7, pp. 973–981, 2006
  20. SPARC Regulates Extracellular Matrix Organization through Its Modulation of Integrin-linked Kinase Activity
    Journal of Biological Chemistry, vol. 280, no. 43, pp. 36483–36493, 2005
  21. Targeted Deletion of Integrin-Linked Kinase Reveals a Role in T-Cell Chemotaxis and Survival
    Molecular and Cellular Biology, vol. 25, no. 24, pp. 11145–11155, 2005
  22. Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy
    Laboratory Investigation, vol. 85, no. 11, Article ID 3700345, 14 pages, 2005
  23. Integrin-linked kinase: a cancer therapeutic target unique among its ILK
    Nature Reviews Cancer, vol. 5, no. 1, Article ID nrc1524, 12 pages, 2005
  24. Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth
    Oncogene, vol. 24, no. 22, Article ID 1208427, 9 pages, 2005
  25. ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling
    Oncogene, vol. 24, no. 19, Article ID 1208525, 11 pages, 2005
  26. Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells
    Oncogene, vol. 24, no. 26, Article ID 1208590, 11 pages, 2005
  27. Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via a-PIX
    Oncogene, vol. 24, no. 38, Article ID 1208737, 12 pages, 2005
  28. Endothelin-1 Promotes Epithelial-to-Mesenchymal Transition in Human Ovarian Cancer Cells
    Cancer Research, vol. 65, no. 24, pp. 11649–11657, 2005
  29. Interaction of Nuclear Receptors with the Wnt/ -Catenin/Tcf Signaling Axis: Wnt You Like to Know?
    Endocrine Reviews, vol. 26, no. 7, pp. 898–915, 2005
  30. Integrin-Linked Kinase Deletion from Mouse Cortex Results in Cortical Lamination Defects Resembling Cobblestone Lissencephaly
    Journal of Neuroscience, vol. 25, no. 30, pp. 7022–7031, 2005
  31. The Tumor Invasion Inhibitor Dihydromotuporamine C Activates RHO, Remodels Stress Fibers and Focal Adhesions, and Stimulates Sodium-Proton Exchange
    Cancer Research, vol. 64, no. 4, pp. 1468–1474, 2004
  32. Regulation of tumor angiogenesis by integrin-linked kinase (ILK)
    Cancer Cell, vol. 5, no. 1, pp. 79–90, 2004
  33. Regulation of E-cadherin expression and ß-catenin/Tcf transcriptional activity by the integrin-linked kinase
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol. 1691, no. 1, pp. 1–15, 2004
  34. NGF-Induced Axon Growth Is Mediated by Localized Inactivation of GSK-3ß and Functions of the Microtubule Plus End Binding Protein APC
    Neuron, vol. 42, no. 6, pp. 897–912, 2004
  35. Integrin-Linked Kinase Regulates Endothelial Cell Survival and Vascular Development
    Molecular and Cellular Biology, vol. 24, no. 18, pp. 8134–8144, 2004
  36. Integrin-linked Kinase Regulates the Nuclear Entry of the c-Jun Coactivator  -NAC and Its Coactivation Potency
    Journal of Biological Chemistry, vol. 279, no. 42, pp. 43893–43899, 2004
  37. Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells
    Oncogene, vol. 23, no. 44, Article ID 1207990, 9 pages, 2004
  38. Conditional Knock-out of Integrin-linked Kinase Demonstrates an Essential Role in Protein Kinase B/Akt Activation
    Journal of Biological Chemistry, vol. 278, no. 25, pp. 22374–22378, 2003
  39. av integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells
    Oncogene, vol. 22, no. 11, Article ID 1206347, 14 pages, 2003
  40. Integration of Cell Attachment, Cytoskeletal Localization, and Signaling by Integrin-linked Kinase (ILK), CH-ILKBP, and the Tumor Suppressor PTEN
    Molecular Biology of the Cell, vol. 14, no. 12, pp. 4813–4825, 2003
  41. Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes
    The Journal of Cell Biology, vol. 162, no. 1, pp. 139–148, 2003
  42. Cancer and Metastasis Reviews, vol. 22, no. 4, pp. 375–384, 2003
  43. Characterisation of integrin-linked kinase signalling in sporadic human colon cancer
    British Journal of Cancer, vol. 88, no. 11, Article ID 6600939, 7 pages, 2003
  44. Integrin-linked Kinase Regulates Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in an NF-kappa B-dependent Manner
    Journal of Biological Chemistry, vol. 277, no. 5, pp. 3109–3116, 2002
  45. Role of Integrin-linked Kinase in Leukocyte Recruitment
    Journal of Biological Chemistry, vol. 277, no. 19, pp. 16371–16375, 2002
  46. Regulation of Protein Kinase B/Akt-Serine 473 Phosphorylation by Integrin-linked Kinase. CRITICAL ROLES FOR KINASE ACTIVITY AND AMINO ACIDS ARGININE 211 AND SERINE 343
    Journal of Biological Chemistry, vol. 276, no. 29, pp. 27462–27469, 2001
  47. Tumor Suppressor PTEN Inhibits Nuclear Accumulation of beta-Catenin and T Cell/Lymphoid Enhancer Factor 1-mediated Transcriptional Activation
    The Journal of Cell Biology, vol. 153, no. 6, pp. 1161–1174, 2001
  48. Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes
    The Journal of Cell Biology, vol. 155, no. 4, pp. 505–510, 2001
  49. Rat Seminiferous Epithelium Contains a Unique Junction (Ectoplasmic Specialization) with Signaling Properties Both of Cell/Cell and Cell/Matrix Junctions
    Biology of Reproduction, vol. 64, no. 1, pp. 396–407, 2001
  50. Inhibition of integrin linked kinase (ILK) suppresses ß-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells
    Oncogene, vol. 20, no. 1, Article ID 1204052, 7 pages, 2001
  51. Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis
    Oncogene, vol. 20, no. 43, Article ID 1204791, 7 pages, 2001
  52. Mammary epithelial-specific expression of the integrin linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice
    Oncogene, vol. 20, no. 48, Article ID 1204910, 8 pages, 2001
  53. Bi-directional signal transduction by integrin receptors
    The International Journal of Biochemistry & Cell Biology, vol. 32, no. 2, pp. 171–188, 2000
  54. The integrin-linked kinase (ILK) suppresses anoikis
    Oncogene, vol. 19, no. 33, pp. 3811–3815, 2000
  55. The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9)
    Oncogene, vol. 19, no. 48, pp. 5444–5452, 2000
  56. Cell–substrate interactions and signaling through ILK
    Current Opinion in Cell Biology, vol. 12, no. 2, pp. 250–256, 2000
  57. Heart, Brain, and Body Wall Defects in Mice Lacking Calreticulin
    Experimental Cell Research, vol. 256, no. 1, pp. 105–111, 2000
  58. Integrin-linked kinase (ILK): a “hot” therapeutic target
    Biochemical Pharmacology, vol. 60, no. 8, pp. 1115–1119, 2000
  59. The Integrin-linked Kinase Regulates the Cyclin D1 Gene through Glycogen Synthase Kinase 3beta and cAMP-responsive Element-binding Protein-dependent Pathways
    Journal of Biological Chemistry, vol. 275, no. 42, pp. 32649–32657, 2000
  60. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells
    Proceedings of the National Academy of Sciences, vol. 97, no. 7, pp. 3207–3212, 2000
  61. Current Opinion in Hematology, vol. 6, no. 1, p. 37, 1999
  62. Signaling through ?-catenin and Lef/Tcf
    Cellular and Molecular Life Sciences (CMLS), vol. 56, no. 5-6, pp. 523–537, 1999
  63. Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling
    Trends in Cell Biology, vol. 9, no. 8, pp. 319–323, 1999
  64. Ligand-specific, transient interaction between integrins and calreticulin during cell adhesion to extracellular matrix proteins is dependent upon phosphorylation/dephosphorylation events
    Biochemical Journal, vol. 340, no. 1, p. 41, 1999
  65. Complement Inhibition Attenuates Human Lung Transplant Reperfusion Injury: A Multicenter Trial
    Chest, vol. 116, no. 90001, pp. 46S–46, 1999
  66. Calreticulin
    The International Journal of Biochemistry & Cell Biology, vol. 30, no. 5, pp. 553–558, 1998
  67. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
    Proceedings of the National Academy of Sciences, vol. 95, no. 19, pp. 11211–11216, 1998
  68. Reciprocal interactions between beta 1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology
    Proceedings of the National Academy of Sciences, vol. 95, no. 25, pp. 14821–14826, 1998
  69. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta -catenin signaling pathways
    Proceedings of the National Academy of Sciences, vol. 95, no. 8, pp. 4374–4379, 1998
  70. Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity
    Journal of Biological Chemistry, vol. 273, no. 1, pp. 528–536, 1998
  71. Overexpression of the Integrin-linked Kinase Promotes Anchorage-independent Cell Cycle Progression
    Journal of Biological Chemistry, vol. 272, no. 21, pp. 13937–13944, 1997
  72. Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion
    Nature, vol. 386, no. 6627, Article ID 386843a0, 4 pages, 1997
  73. Protein kinase mediators of integrin signal transduction
    Journal of Molecular Medicine, vol. 75, no. 1, pp. 35–44, 1997
  74. Modulation of the Retinoic Acid and Retinoid X Receptor Signaling Pathways in P19 Embryonal Carcinoma Cells by Calreticulin
    Experimental Cell Research, vol. 230, no. 1, pp. 50–60, 1997
  75. Mapping of the Gene Encoding the Integrin-Linked Kinase, ILK, to Human Chromosome 11p15.5–p15.4
    Genomics, vol. 42, no. 1, pp. 177–179, 1997
  76. Integrin cytoplasmic interactions and bidirectional transmembrane signalling
    Current Opinion in Cell Biology, vol. 8, no. 5, pp. 657–669, 1996
  77. Regulation of cell adhesion and anchorage-dependent growth by a new ß1-integrin-linked protein kinase
    Nature, vol. 379, no. 6560, Article ID 379091a0, 5 pages, 1996
  78. Association of 1 alpha,25-dihydroxyvitamin D3-occupied vitamin D receptors with cellular membrane acceptance sites
    Endocrinology, vol. 137, no. 9, pp. 3649–3658, 1996
  79. Inducible Interaction of Integrin alpha(2)beta(1) with Calreticulin
    Journal of Biological Chemistry, vol. 270, no. 39, pp. 23132–23138, 1995
  80. Constitutive expression of calreticulin in osteoblasts inhibits mineralization
    The Journal of Cell Biology, vol. 131, no. 5, pp. 1351–1359, 1995
  81. Inhibition of nuclear hormone receptor activity by calreticulin
    Nature, vol. 367, no. 6462, Article ID 367480a0, 3 pages, 1994
  82. Novel functions for calreticulin: interaction with integrins and modulation of gene expression?
    Trends in Biochemical Sciences, vol. 19, no. 7, pp. 269–271, 1994
  83. The effect of GM-CSF and G-CSF on the growth of human osteosarcoma cellsin vitro andin vivo
    International Journal of Cancer, vol. 56, no. 2, pp. 236–243, 1994
  84. Reciprocal Interactions between Human Ovarian Surface Epithelial Cells and Adjacent Extracellular Matrix
    Experimental Cell Research, vol. 215, no. 1, pp. 97–108, 1994
  85. Specific alterations in the expression of ?3?1 and ?6?4 integrins in highly invasive and metastatic variants of human prostate carcinoma cells selected by in vitro invasion through reconstituted basement membrane
    Clinical & Experimental Metastasis, vol. 11, no. 5, pp. 391–400, 1993
  86. Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1? in human osteosarcoma cells: Inhibition of cell proliferation and stimulation of alkaline phosphatase activity
    Journal of Cellular Physiology, vol. 138, no. 2, pp. 291–299, 1989
  87. Signal transduction via the ?1 integrins is a required intermediate in interleukin-1? induction of alkaline phosphatase activity in human osteosarcoma cells*1
    Experimental Cell Research, vol. 183, no. 1, pp. 207–214, 1989
  88. Human Granulocyte-Macrophage Colony-Stimulating Factor is a Growth Factor Active on a Variety of Cell Types of Nonhemopoietic Origin
    Proceedings of the National Academy of Sciences, vol. 85, no. 23, pp. 9253–9257, 1988
  89. A cell surface receptor complex for collagen type I recognizes the Arg- Gly-Asp sequence
    The Journal of Cell Biology, vol. 104, no. 3, pp. 585–593, 1987
  90. Human osteosarcoma cells resistant to detachment by an Arg-Gly-Asp- containing peptide overproduce the fibronectin receptor
    The Journal of Cell Biology, vol. 105, no. 3, pp. 1175–1182, 1987