Shoukat Dedhar
Personal Home Page
http://www.biochem.ubc.ca/fac_research/faculty/dedhar.html
Articles in Scholarly Journals [Incomplete List]
- Loss of integrin linked kinase from mouse hepatocytesin vitro andin vivo results in apoptosis and hepatitis
Hepatology, vol. 45, no. 4, pp. 1025–1034, 2007 - Role of the integrin-linked kinase (ILK) in determining neuronal polarity
Developmental Biology, vol. 306, no. 2, pp. 457–468, 2007 - Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion
Cellular Microbiology, vol. 9, no. 6, pp. 1519–1528, 2007 - Integrin-Linked Kinase at the Heart of Cardiac Contractility, Repair, and Disease
Circulation Research, vol. 100, no. 10, pp. 1408–1414, 2007 - Tubular Epithelial Cell Dedifferentiation Is Driven by the Helix-Loop-Helix Transcriptional Inhibitor Id1
Journal of the American Society of Nephrology, vol. 18, no. 2, pp. 449–460, 2007 - Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium
AJP: Cell Physiology, vol. 290, no. 6, pp. C1532–C1542, 2006 - Preferential Dependence of Breast Cancer Cells versus Normal Cells on Integrin-Linked Kinase for Protein Kinase B/Akt Activation and Cell Survival
Cancer Research, vol. 66, no. 1, pp. 393–403, 2006 - Inhibition of the Phosphatidylinositol 3'-Kinase Pathway Promotes Autocrine Fas-Induced Death of Phosphatase and Tensin Homologue-Deficient Prostate Cancer Cells
Cancer Research, vol. 66, no. 9, pp. 4781–4788, 2006 - Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells
Molecular Cancer Therapeutics, vol. 5, no. 3, pp. 645–654, 2006 - Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma
Molecular Cancer Therapeutics, vol. 5, no. 4, pp. 833–842, 2006 - Novel Role for Integrin-Linked Kinase in Modulation of Coxsackievirus B3 Replication and Virus-Induced Cardiomyocyte Injury
Circulation Research, vol. 99, no. 4, pp. 354–361, 2006 - Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism
Journal of Cell Science, vol. 119, no. 13, pp. 2787–2796, 2006 - Critical Role of Integrin-Linked Kinase in Granule Cell Precursor Proliferation and Cerebellar Development
Journal of Neuroscience, vol. 26, no. 3, pp. 830–840, 2006 - An Essential Role for the Integrin-Linked Kinase-Glycogen Synthase Kinase-3 Pathway during Dendrite Initiation and Growth
Journal of Neuroscience, vol. 26, no. 51, pp. 13344–13356, 2006 - Podocyte-Specific Deletion of Integrin-Linked Kinase Results in Severe Glomerular Basement Membrane Alterations and Progressive Glomerulosclerosis
Journal of the American Society of Nephrology, vol. 17, no. 5, pp. 1334–1344, 2006 - Essential Role of Integrin-Linked Kinase in Podocyte Biology: Bridging the Integrin and Slit Diaphragm Signaling
Journal of the American Society of Nephrology, vol. 17, no. 8, pp. 2164–2175, 2006 - Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure
Genes & Development, vol. 20, no. 17, pp. 2355–2360, 2006 - Integrin-linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells
Cellular Microbiology, vol. 8, no. 2, pp. 257–266, 2006 - The epithelial-mesenchymal transition: new insights in signaling, development, and disease
The Journal of Cell Biology, vol. 172, no. 7, pp. 973–981, 2006 - SPARC Regulates Extracellular Matrix Organization through Its Modulation of Integrin-linked Kinase Activity
Journal of Biological Chemistry, vol. 280, no. 43, pp. 36483–36493, 2005 - Targeted Deletion of Integrin-Linked Kinase Reveals a Role in T-Cell Chemotaxis and Survival
Molecular and Cellular Biology, vol. 25, no. 24, pp. 11145–11155, 2005 - Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy
Laboratory Investigation, vol. 85, no. 11, Article ID 3700345, 14 pages, 2005 - Integrin-linked kinase: a cancer therapeutic target unique among its ILK
Nature Reviews Cancer, vol. 5, no. 1, Article ID nrc1524, 12 pages, 2005 - Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth
Oncogene, vol. 24, no. 22, Article ID 1208427, 9 pages, 2005 - ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling
Oncogene, vol. 24, no. 19, Article ID 1208525, 11 pages, 2005 - Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells
Oncogene, vol. 24, no. 26, Article ID 1208590, 11 pages, 2005 - Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via a-PIX
Oncogene, vol. 24, no. 38, Article ID 1208737, 12 pages, 2005 - Endothelin-1 Promotes Epithelial-to-Mesenchymal Transition in Human Ovarian Cancer Cells
Cancer Research, vol. 65, no. 24, pp. 11649–11657, 2005 - Interaction of Nuclear Receptors with the Wnt/ -Catenin/Tcf Signaling Axis: Wnt You Like to Know?
Endocrine Reviews, vol. 26, no. 7, pp. 898–915, 2005 - Integrin-Linked Kinase Deletion from Mouse Cortex Results in Cortical Lamination Defects Resembling Cobblestone Lissencephaly
Journal of Neuroscience, vol. 25, no. 30, pp. 7022–7031, 2005 - The Tumor Invasion Inhibitor Dihydromotuporamine C Activates RHO, Remodels Stress Fibers and Focal Adhesions, and Stimulates Sodium-Proton Exchange
Cancer Research, vol. 64, no. 4, pp. 1468–1474, 2004 - Regulation of tumor angiogenesis by integrin-linked kinase (ILK)
Cancer Cell, vol. 5, no. 1, pp. 79–90, 2004 - Regulation of E-cadherin expression and ß-catenin/Tcf transcriptional activity by the integrin-linked kinase
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol. 1691, no. 1, pp. 1–15, 2004 - NGF-Induced Axon Growth Is Mediated by Localized Inactivation of GSK-3ß and Functions of the Microtubule Plus End Binding Protein APC
Neuron, vol. 42, no. 6, pp. 897–912, 2004 - Integrin-Linked Kinase Regulates Endothelial Cell Survival and Vascular Development
Molecular and Cellular Biology, vol. 24, no. 18, pp. 8134–8144, 2004 - Integrin-linked Kinase Regulates the Nuclear Entry of the c-Jun Coactivator -NAC and Its Coactivation Potency
Journal of Biological Chemistry, vol. 279, no. 42, pp. 43893–43899, 2004 - Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells
Oncogene, vol. 23, no. 44, Article ID 1207990, 9 pages, 2004 - Conditional Knock-out of Integrin-linked Kinase Demonstrates an Essential Role in Protein Kinase B/Akt Activation
Journal of Biological Chemistry, vol. 278, no. 25, pp. 22374–22378, 2003 - av integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells
Oncogene, vol. 22, no. 11, Article ID 1206347, 14 pages, 2003 - Integration of Cell Attachment, Cytoskeletal Localization, and Signaling by Integrin-linked Kinase (ILK), CH-ILKBP, and the Tumor Suppressor PTEN
Molecular Biology of the Cell, vol. 14, no. 12, pp. 4813–4825, 2003 - Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes
The Journal of Cell Biology, vol. 162, no. 1, pp. 139–148, 2003 - Cancer and Metastasis Reviews, vol. 22, no. 4, pp. 375–384, 2003
- Characterisation of integrin-linked kinase signalling in sporadic human colon cancer
British Journal of Cancer, vol. 88, no. 11, Article ID 6600939, 7 pages, 2003 - Integrin-linked Kinase Regulates Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in an NF-kappa B-dependent Manner
Journal of Biological Chemistry, vol. 277, no. 5, pp. 3109–3116, 2002 - Role of Integrin-linked Kinase in Leukocyte Recruitment
Journal of Biological Chemistry, vol. 277, no. 19, pp. 16371–16375, 2002 - Regulation of Protein Kinase B/Akt-Serine 473 Phosphorylation by Integrin-linked Kinase. CRITICAL ROLES FOR KINASE ACTIVITY AND AMINO ACIDS ARGININE 211 AND SERINE 343
Journal of Biological Chemistry, vol. 276, no. 29, pp. 27462–27469, 2001 - Tumor Suppressor PTEN Inhibits Nuclear Accumulation of beta-Catenin and T Cell/Lymphoid Enhancer Factor 1-mediated Transcriptional Activation
The Journal of Cell Biology, vol. 153, no. 6, pp. 1161–1174, 2001 - Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes
The Journal of Cell Biology, vol. 155, no. 4, pp. 505–510, 2001 - Rat Seminiferous Epithelium Contains a Unique Junction (Ectoplasmic Specialization) with Signaling Properties Both of Cell/Cell and Cell/Matrix Junctions
Biology of Reproduction, vol. 64, no. 1, pp. 396–407, 2001 - Inhibition of integrin linked kinase (ILK) suppresses ß-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells
Oncogene, vol. 20, no. 1, Article ID 1204052, 7 pages, 2001 - Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis
Oncogene, vol. 20, no. 43, Article ID 1204791, 7 pages, 2001 - Mammary epithelial-specific expression of the integrin linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice
Oncogene, vol. 20, no. 48, Article ID 1204910, 8 pages, 2001 - Bi-directional signal transduction by integrin receptors
The International Journal of Biochemistry & Cell Biology, vol. 32, no. 2, pp. 171–188, 2000 - The integrin-linked kinase (ILK) suppresses anoikis
Oncogene, vol. 19, no. 33, pp. 3811–3815, 2000 - The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9)
Oncogene, vol. 19, no. 48, pp. 5444–5452, 2000 - Cell–substrate interactions and signaling through ILK
Current Opinion in Cell Biology, vol. 12, no. 2, pp. 250–256, 2000 - Heart, Brain, and Body Wall Defects in Mice Lacking Calreticulin
Experimental Cell Research, vol. 256, no. 1, pp. 105–111, 2000 - Integrin-linked kinase (ILK): a “hot” therapeutic target
Biochemical Pharmacology, vol. 60, no. 8, pp. 1115–1119, 2000 - The Integrin-linked Kinase Regulates the Cyclin D1 Gene through Glycogen Synthase Kinase 3beta and cAMP-responsive Element-binding Protein-dependent Pathways
Journal of Biological Chemistry, vol. 275, no. 42, pp. 32649–32657, 2000 - Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells
Proceedings of the National Academy of Sciences, vol. 97, no. 7, pp. 3207–3212, 2000 - Current Opinion in Hematology, vol. 6, no. 1, p. 37, 1999
- Signaling through ?-catenin and Lef/Tcf
Cellular and Molecular Life Sciences (CMLS), vol. 56, no. 5-6, pp. 523–537, 1999 - Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling
Trends in Cell Biology, vol. 9, no. 8, pp. 319–323, 1999 - Ligand-specific, transient interaction between integrins and calreticulin during cell adhesion to extracellular matrix proteins is dependent upon phosphorylation/dephosphorylation events
Biochemical Journal, vol. 340, no. 1, p. 41, 1999 - Complement Inhibition Attenuates Human Lung Transplant Reperfusion Injury: A Multicenter Trial
Chest, vol. 116, no. 90001, pp. 46S–46, 1999 - Calreticulin
The International Journal of Biochemistry & Cell Biology, vol. 30, no. 5, pp. 553–558, 1998 - Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
Proceedings of the National Academy of Sciences, vol. 95, no. 19, pp. 11211–11216, 1998 - Reciprocal interactions between beta 1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology
Proceedings of the National Academy of Sciences, vol. 95, no. 25, pp. 14821–14826, 1998 - Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta -catenin signaling pathways
Proceedings of the National Academy of Sciences, vol. 95, no. 8, pp. 4374–4379, 1998 - Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity
Journal of Biological Chemistry, vol. 273, no. 1, pp. 528–536, 1998 - Overexpression of the Integrin-linked Kinase Promotes Anchorage-independent Cell Cycle Progression
Journal of Biological Chemistry, vol. 272, no. 21, pp. 13937–13944, 1997 - Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion
Nature, vol. 386, no. 6627, Article ID 386843a0, 4 pages, 1997 - Protein kinase mediators of integrin signal transduction
Journal of Molecular Medicine, vol. 75, no. 1, pp. 35–44, 1997 - Modulation of the Retinoic Acid and Retinoid X Receptor Signaling Pathways in P19 Embryonal Carcinoma Cells by Calreticulin
Experimental Cell Research, vol. 230, no. 1, pp. 50–60, 1997 - Mapping of the Gene Encoding the Integrin-Linked Kinase, ILK, to Human Chromosome 11p15.5–p15.4
Genomics, vol. 42, no. 1, pp. 177–179, 1997 - Integrin cytoplasmic interactions and bidirectional transmembrane signalling
Current Opinion in Cell Biology, vol. 8, no. 5, pp. 657–669, 1996 - Regulation of cell adhesion and anchorage-dependent growth by a new ß1-integrin-linked protein kinase
Nature, vol. 379, no. 6560, Article ID 379091a0, 5 pages, 1996 - Association of 1 alpha,25-dihydroxyvitamin D3-occupied vitamin D receptors with cellular membrane acceptance sites
Endocrinology, vol. 137, no. 9, pp. 3649–3658, 1996 - Inducible Interaction of Integrin alpha(2)beta(1) with Calreticulin
Journal of Biological Chemistry, vol. 270, no. 39, pp. 23132–23138, 1995 - Constitutive expression of calreticulin in osteoblasts inhibits mineralization
The Journal of Cell Biology, vol. 131, no. 5, pp. 1351–1359, 1995 - Inhibition of nuclear hormone receptor activity by calreticulin
Nature, vol. 367, no. 6462, Article ID 367480a0, 3 pages, 1994 - Novel functions for calreticulin: interaction with integrins and modulation of gene expression?
Trends in Biochemical Sciences, vol. 19, no. 7, pp. 269–271, 1994 - The effect of GM-CSF and G-CSF on the growth of human osteosarcoma cellsin vitro andin vivo
International Journal of Cancer, vol. 56, no. 2, pp. 236–243, 1994 - Reciprocal Interactions between Human Ovarian Surface Epithelial Cells and Adjacent Extracellular Matrix
Experimental Cell Research, vol. 215, no. 1, pp. 97–108, 1994 - Specific alterations in the expression of ?3?1 and ?6?4 integrins in highly invasive and metastatic variants of human prostate carcinoma cells selected by in vitro invasion through reconstituted basement membrane
Clinical & Experimental Metastasis, vol. 11, no. 5, pp. 391–400, 1993 - Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1? in human osteosarcoma cells: Inhibition of cell proliferation and stimulation of alkaline phosphatase activity
Journal of Cellular Physiology, vol. 138, no. 2, pp. 291–299, 1989 - Signal transduction via the ?1 integrins is a required intermediate in interleukin-1? induction of alkaline phosphatase activity in human osteosarcoma cells*1
Experimental Cell Research, vol. 183, no. 1, pp. 207–214, 1989 - Human Granulocyte-Macrophage Colony-Stimulating Factor is a Growth Factor Active on a Variety of Cell Types of Nonhemopoietic Origin
Proceedings of the National Academy of Sciences, vol. 85, no. 23, pp. 9253–9257, 1988 - A cell surface receptor complex for collagen type I recognizes the Arg- Gly-Asp sequence
The Journal of Cell Biology, vol. 104, no. 3, pp. 585–593, 1987 - Human osteosarcoma cells resistant to detachment by an Arg-Gly-Asp- containing peptide overproduce the fibronectin receptor
The Journal of Cell Biology, vol. 105, no. 3, pp. 1175–1182, 1987