Jan H.M. Schellens

Articles in Scholarly Journals [Incomplete List]

  1. Determination of ruthenium originating from the investigational anti-cancer drug NAMI-A in human plasma ultrafiltrate, plasma, and urine by inductively coupled plasma mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 21, no. 9, pp. 1521–1530, 2007
  2. Liquid chromatography–tandem mass spectrometric assay for the nucleoside reverse transcriptase inhibitor emtricitabine in human plasma
    Biomedical Chromatography, vol. 21, no. 6, pp. 621–627, 2007
  3. Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 21, no. 14, pp. 2312–2322, 2007
  4. Severe pulmonary toxicity in patients with leiomyosarcoma after treatment with gemcitabine and docetaxel
    Investigational New Drugs, vol. 25, no. 3, pp. 279–281, 2007
  5. Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry
    Investigational New Drugs, vol. 25, no. 4, pp. 327–334, 2007
  6. Determination of imatinib mesylate and its main metabolite (CGP74588) in human plasma and murine specimens by ion-pairing reversed-phase high-performance liquid chromatography
    Biomedical Chromatography, vol. 21, no. 7, pp. 747–754, 2007
  7. Novel paclitaxel formulations for oral application: a phase I pharmacokinetic study in patients with solid tumours
    Cancer Chemotherapy and Pharmacology, vol. 60, no. 5, pp. 635–642, 2007
  8. Is rectal administration an alternative route for imatinib?
    Cancer Chemotherapy and Pharmacology, vol. 60, no. 4, pp. 623–624, 2007
  9. Monitoring of platinum surface contamination in seven Dutch hospital pharmacies using inductively coupled plasma mass spectrometry
    International Archives of Occupational and Environmental Health, vol. 80, no. 8, pp. 689–699, 2007
  10. The role of nuclear receptors in pharmacokinetic drug–drug interactions in oncology
    Cancer Treatment Reviews, vol. 33, no. 4, pp. 369–380, 2007
  11. Phase I and pharmacokinetic trial of AP5346, a DACH–platinum–polymer conjugate, administered weekly for three out of every 4 weeks to advanced solid tumor patients
    Cancer Chemotherapy and Pharmacology, vol. 60, no. 4, pp. 523–533, 2007
  12. Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy
    Cancer Treatment Reviews, vol. 33, no. 2, pp. 191–202, 2007
  13. Enzymatic digestion as a tool for the LC–MS/MS quantification of large peptides in biological matrices: Measurement of chymotryptic fragments from the HIV-1 fusion inhibitor enfuvirtide and its metabolite M-20 in human plasma
    Journal of Chromatography B, vol. 854, no. 1-2, pp. 245–259, 2007
  14. Liquid chromatography–tandem mass spectrometric assays for salinomycin in mouse plasma, liver, brain and small intestinal contents and in OptiMEM cell culture medium
    Journal of Chromatography B, vol. 855, no. 2, pp. 200–210, 2007
  15. Stability experiments in human urine with EO9 (apaziquone): A novel anticancer agent for the intravesical treatment of bladder cancer
    Journal of Pharmaceutical and Biomedical Analysis, vol. 43, no. 1, pp. 285–292, 2007
  16. Validation of SELDI-TOF MS serum protein profiles for renal cell carcinoma in new populations
    Laboratory Investigation, vol. 87, no. 2, Article ID 3700503, 11 pages, 2007
  17. Pharmacogenetic Screening of the Gene Deletion and Duplications of CYP2D6
    Drug Metabolism Reviews, vol. 39, no. 1, pp. 45–60, 2007
  18. Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral Protein Kinase C  -Inhibitor Enzastaurin in Combination with Gemcitabine and Cisplatin in Patients with Advanced Cancer
    Clinical Cancer Research, vol. 13, no. 15, pp. 4474–4481, 2007
  19. CYP2C9 and CYP2C19 Polymorphic Forms Are Related to Increased Indisulam Exposure and Higher Risk of Severe Hematologic Toxicity
    Clinical Cancer Research, vol. 13, no. 10, pp. 2970–2976, 2007
  20. A Phase I, Randomized, Open-Label, Parallel-Cohort, Dose-Finding Study of Elacridar (GF120918) and Oral Topotecan in Cancer Patients
    Clinical Cancer Research, vol. 13, no. 11, pp. 3276–3285, 2007
  21. Phase I Pharmacokinetic Study of the Safety and Tolerability of Lapatinib (GW572016) in Combination with Oxaliplatin/Fluorouracil/Leucovorin (FOLFOX4) in Patients with Solid Tumors
    Clinical Cancer Research, vol. 13, no. 15, pp. 4495–4502, 2007
  22. A Phase I Safety and Pharmacologic Study of a Twice Weekly Dosing Regimen of the Oral Taxane BMS-275183
    Clinical Cancer Research, vol. 13, no. 13, pp. 3906–3912, 2007
  23. Capecitabine
    The Oncologist, vol. 12, no. 2, pp. 152–155, 2007
  24. Clinical and Pharmacologic Study of the Farnesyltransferase Inhibitor Tipifarnib in Cancer Patients With Normal or Mildly or Moderately Impaired Hepatic Function
    Journal of Clinical Oncology, vol. 24, no. 28, pp. 4558–4564, 2006
  25. Genetic Polymorphisms of Drug Metabolising Enzymes and Drug Transporters in Relation to Cancer Risk
    Current Cancer Therapy Reviews, vol. 2, no. 2, pp. 137–155, 2006
  26. Determinants of the elimination of methotrexate and 7-hydroxy-methotrexate following high-dose infusional therapy to cancer patients
    British Journal of Clinical Pharmacology, vol. 62, no. 1, pp. 71–80, 2006
  27. Symptoms and Treatment in Cancer Therapy-Induced Early Menopause
    The Oncologist, vol. 11, no. 6, pp. 641–654, 2006
  28. Herb-Drug Interactions in Oncology: Focus on Mechanisms of Induction
    The Oncologist, vol. 11, no. 7, pp. 742–752, 2006
  29. Photodynamic Therapy in Oncology
    The Oncologist, vol. 11, no. 9, pp. 1034–1044, 2006
  30. Saturable binding of indisulam to plasma proteins and distribution to human erythrocytes
    Drug Metabolism and Disposition, 2006
  31. Relationship Between Cisplatin Administration and the Development of Ototoxicity
    Journal of Clinical Oncology, vol. 24, no. 6, pp. 918–924, 2006
  32. Dose-Finding Phase I Clinical and Pharmacokinetic Study of Orally Administered Irinotecan in Patients with Advanced Solid Tumors
    Clinical Cancer Research, vol. 12, no. 12, pp. 3774–3781, 2006
  33. Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs
    Trends in Pharmacological Sciences, vol. 27, no. 1, pp. 17–24, 2006
  34. The Effect of Low pH on Breast Cancer Resistance Protein (ABCG2)-Mediated Transport of Methotrexate, 7-Hydroxymethotrexate, Methotrexate Diglutamate, Folic Acid, Mitoxantrone, Topotecan, and Resveratrol in In Vitro Drug Transport Models
    Molecular Pharmacology, vol. 71, no. 1, pp. 240–249, 2006
  35. Mass Balance Studies, with a Focus on Anticancer Drugs
    Clinical Pharmacokinetics, vol. 45, no. 1, pp. 33–58, 2006
  36. Genetic Polymorphisms of Drug-Metabolising Enzymes and Drug Transporters in the Chemotherapeutic Treatment of Cancer
    Clinical Pharmacokinetics, vol. 45, no. 3, pp. 253–285, 2006
  37. Pharmacogenetic Screening of CYP3A and ABCB1 in Relation to Population Pharmacokinetics of Docetaxel
    Clinical Cancer Research, vol. 12, no. 19, pp. 5786–5793, 2006
  38. Flat Dosing of Carboplatin Is Justified in Adult Patients with Normal Renal Function
    Clinical Cancer Research, vol. 12, no. 21, pp. 6502–6508, 2006
  39. Interactions of Serum Albumin, Valproic Acid and Carbamazepine with the Pharmacokinetics of Phenytoin in Cancer Patients
    Basic Clinical Pharmacology Toxicology, vol. 99, no. 2, pp. 133–140, 2006
  40. Analytical Chemistry, vol. 78, no. 8, pp. 2617–2622, 2006
  41. Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei
    Nucleic Acids Research, vol. 34, no. 6, pp. e47–e47, 2006
  42. Carcinogen and Anticancer Drug Transport by Mrp2 in Vivo: Studies Using Mrp2 (Abcc2) Knockout Mice
    Journal of Pharmacology and Experimental Therapeutics, vol. 318, no. 1, pp. 319–327, 2006
  43. Radiosensitization of Squamous Cell Carcinoma by the Alkylphospholipid Perifosine in Cell Culture and Xenografts
    Clinical Cancer Research, vol. 12, no. 5, pp. 1615–1622, 2006
  44. Quantitative Effect of Gender, Age, Liver Function, and Body Size on the Population Pharmacokinetics of Paclitaxel in Patients with Solid Tumors
    Clinical Cancer Research, vol. 12, no. 7, pp. 2150–2157, 2006
  45. A novel self-microemulsifying formulation of paclitaxel for oral administration to patients with advanced cancer
    British Journal of Cancer, vol. 95, no. 6, Article ID 6603312, 5 pages, 2006
  46. Phase II and pharmacological study of oral paclitaxel (Paxoral) plus ciclosporin in anthracycline-pretreated metastatic breast cancer
    British Journal of Cancer, vol. 95, no. 7, Article ID 6603332, 6 pages, 2006
  47. Clinical proteomics: searching for better tumour markers with SELDI-TOF mass spectrometry
    Trends in Pharmacological Sciences, vol. 27, no. 5, pp. 251–259, 2006
  48. Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours
    Radiotherapy and Oncology, vol. 80, no. 2, pp. 207–213, 2006
  49. Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry
    Analytical Biochemistry, vol. 352, no. 1, pp. 33–40, 2006
  50. Future opportunities in preventing cisplatin induced ototoxicity
    Cancer Treatment Reviews, vol. 32, no. 5, pp. 390–397, 2006
  51. Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines
    Toxicology and Applied Pharmacology, vol. 211, no. 1, pp. 1–10, 2006
  52. Screening for polymorphisms in the PXR gene in a Dutch population
    European Journal of Clinical Pharmacology, vol. 62, no. 5, pp. 395–399, 2006
  53. A Semi-Physiological Population Pharmacokinetic Model Describing the Non-linear Disposition of Indisulam
    Journal of Pharmacokinetics and Pharmacodynamics, vol. 33, no. 5, pp. 543–570, 2006
  54. Metabolism of trabectedin (ET-743, Yondelis™) in patients with advanced cancer
    Cancer Chemotherapy and Pharmacology, vol. 59, no. 6, pp. 825–837, 2006
  55. The pharmacokinetic behavior of the photosensitizer meso-tetra-hydroxyphenyl-chlorin in mice and men
    Cancer Chemotherapy and Pharmacology, vol. 60, no. 1, pp. 113–122, 2006
  56. A pharmacokinetic and safety study of a novel polymeric paclitaxel formulation for oral application
    Cancer Chemotherapy and Pharmacology, vol. 59, no. 1, pp. 43–50, 2006
  57. Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers
    European Journal of Clinical Pharmacology, vol. 62, no. 8, pp. 681–684, 2006
  58. Liquid chromatography–tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and ß-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes?
    Journal of Chromatography B, vol. 839, no. 1-2, pp. 45–53, 2006
  59. Development and validation of a quantitative assay for the measurement of two HIV-fusion inhibitors, enfuvirtide and tifuvirtide, and one metabolite of enfuvirtide (M-20) in human plasma by liquid chromatography–tandem mass spectrometry
    Journal of Chromatography B, vol. 837, no. 1-2, pp. 49–58, 2006
  60. Trabectedin (ET-743, Yondelis™) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype
    Investigational New Drugs, vol. 25, no. 1, pp. 1–7, 2006
  61. Phase I dose-finding and pharmacokinetic trial of orally administered indibulin (D-24851) to patients with solid tumors
    Investigational New Drugs, vol. 25, no. 3, pp. 227–235, 2006
  62. In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis®, Trabectidin®), a novel marine anti-cancer drug
    Investigational New Drugs, vol. 24, no. 1, pp. 3–14, 2006
  63. In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug
    Investigational New Drugs, vol. 25, no. 1, pp. 9–19, 2006
  64. The effect of hydroxyurea on P-glycoprotein/BCRP-mediated transport and CYP3A metabolism of imatinib mesylate
    Cancer Chemotherapy and Pharmacology, vol. 59, no. 6, pp. 855–860, 2006
  65. Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry
    Journal of Mass Spectrometry, vol. 41, no. 12, pp. 1633–1642, 2006
  66. Sensitive inductively coupled plasma mass spectrometry assay for the determination of platinum originating from cisplatin, carboplatin, and oxaliplatin in human plasma ultrafiltrate
    Journal of Mass Spectrometry, vol. 41, no. 9, pp. 1186–1194, 2006
  67. Quantitative analysis of EO9 (apaziquone) and its metabolite EO5a in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray tandem mass spectrometry
    Journal of Mass Spectrometry, vol. 41, no. 10, pp. 1268–1276, 2006
  68. Prediction of treatment outcome by cisplatin-DNA adduct formation in patients with stage III/IV head and neck squamous cell carcinoma, treated by concurrent cisplatin-radiation (RADPLAT)
    International Journal of Cancer, vol. 119, no. 4, pp. 750–756, 2006
  69. Liquid chromatographic assay for the non-peptidic protease inhibitor tipranavir in plasma
    Biomedical Chromatography, vol. 20, no. 8, pp. 671–673, 2006
  70. A rapid and simple HPLC-UV method for the determination of inhibition characteristics of farnesyl transferase inhibitors
    Biomedical Chromatography, vol. 20, no. 2, pp. 161–165, 2006
  71. A simple and sensitive assay for the quantitative analysis of paclitaxel and metabolites in human plasma using liquid chromatography/tandem mass spectrometry
    Biomedical Chromatography, vol. 20, no. 1, pp. 139–148, 2005
  72. Liquid chromatographic assay for the protease inhibitor atazanavir in plasma
    Biomedical Chromatography, vol. 20, no. 1, pp. 72–76, 2005
  73. Quantitative analysis of docetaxel in human plasma using liquid chromatography coupled with tandem mass spectrometry
    Biomedical Chromatography, vol. 19, no. 5, pp. 355–361, 2005
  74. Determination of oxaliplatin in human plasma and plasma ultrafiltrate by graphite-furnace atomic-absorption spectrometry
    Analytical and Bioanalytical Chemistry, vol. 382, no. 7, pp. 1484–1490, 2005
  75. Quantitative analysis of the farnesyl transferase inhibitor lonafarnib (Sarasar™, SCH66336) in human plasma using high-performance liquid chromatography coupled with tandem mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 19, no. 15, pp. 2187–2192, 2005
  76. Structure elucidation of aplidine metabolites formedin vitro by human liver microsomes using triple quadrupole mass spectrometry
    Journal of Mass Spectrometry, vol. 40, no. 6, pp. 821–831, 2005
  77. Pharmacokinetics of low-dose doxorubicin and metabolites in patients with AIDS-related Kaposi sarcoma
    Cancer Chemotherapy and Pharmacology, vol. 55, no. 5, pp. 488–496, 2005
  78. Metabolism of docetaxel in mice
    Cancer Chemotherapy and Pharmacology, vol. 56, no. 3, pp. 299–306, 2005
  79. Absence of N-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP/ABCG2)
    Cancer Chemotherapy and Pharmacology, vol. 56, no. 4, pp. 344–350, 2005
  80. Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid
    Investigational New Drugs, vol. 23, no. 4, pp. 279–286, 2005
  81. Human metabolism of [14C]indisulam following i.v. infusion in cancer patients
    Investigational New Drugs, vol. 23, no. 4, pp. 317–330, 2005
  82. Trabectedin (YondelisTM, formerly ET-743), a mass balance study in patients with advanced cancer
    Investigational New Drugs, vol. 23, no. 5, pp. 429–436, 2005
  83. Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam
    Investigational New Drugs, vol. 23, no. 3, pp. 225–234, 2005
  84. Hepatotoxicity and metabolism of trabectedin: a literature review
    Pharmacological Research, 2005
  85. Chronic hepatotoxicity after long-term antiretroviral treatment including nevirapine
    Journal of Infection, vol. 50, no. 3, pp. 262–264, 2005
  86. Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra®, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumours
    British Journal of Cancer, vol. 93, no. 11, Article ID 6602850, 7 pages, 2005
  87. Modulation of Oral Drug Bioavailability: From Preclinical Mechanism to Therapeutic Application
    Cancer Investigation, vol. 23, no. 5, pp. 443–464, 2005
  88. No pharmacokinetic drug???drug interaction between nevirapine and paclitaxel
    Anti-Cancer Drugs, vol. 16, no. 6, pp. 627–630, 2005
  89. Breast Cancer Resistance Protein (Bcrp1/Abcg2) Limits Net Intestinal Uptake of Quercetin in Rats by Facilitating Apical Efflux of Glucuronides
    Molecular Pharmacology, vol. 67, no. 6, pp. 1999–2006, 2005
  90. Phase I Clinical and Pharmacokinetic Study of Kahalalide F in Patients with Advanced Androgen Refractory Prostate Cancer
    Clinical Cancer Research, vol. 11, no. 5, pp. 1854–1862, 2005
  91. Phase I clinical and pharmacologic study of a 2-weekly administration of cisplatin and gemcitabine in patients with advanced non-small cell lung cancer
    Anti-Cancer Drugs, vol. 16, no. 9, pp. 1029–1036, 2005
  92. In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction
    Anti-Cancer Drugs, vol. 16, no. 9, pp. 935–943, 2005
  93. Population pharmacokinetics of orally administered paclitaxel formulated in Cremophor EL
    British Journal of Clinical Pharmacology, vol. 59, no. 3, pp. 325–334, 2005
  94. Development of Farnesyl Transferase Inhibitors: A Review
    The Oncologist, vol. 10, no. 8, pp. 565–578, 2005
  95. Current Knowledge and Future Directions of the Selective Epidermal Growth Factor Receptor Inhibitors Erlotinib (Tarceva(R)) and Gefitinib (Iressa(R))
    The Oncologist, vol. 10, no. 8, pp. 579–589, 2005
  96. Cannulation of the jugular vein in mice
    Laboratory Animals, vol. 39, no. 1, pp. 130–132, 2005
  97. MIDAZOLAM AND CYCLOSPORIN A METABOLISM IN TRANSGENIC MICE WITH LIVER-SPECIFIC EXPRESSION OF HUMAN CYP3A4
    Drug Metabolism and Disposition, vol. 33, no. 7, pp. 892–895, 2005
  98. The Effect of Bcrp1 (Abcg2) on the In vivo Pharmacokinetics and Brain Penetration of Imatinib Mesylate (Gleevec): Implications for the Use of Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors to Enable the Brain Penetration of Imatinib in Patients
    Cancer Research, vol. 65, no. 7, pp. 2577–2582, 2005
  99. Individualised Cancer Chemotherapy: Strategies and Performance of Prospective Studies on Therapeutic Drug Monitoring with Dose Adaptation
    Clinical Pharmacokinetics, vol. 44, no. 2, pp. 147–173, 2005
  100. Detection of Single Nucleotide Polymorphisms in the ABCG2 Gene in a Dutch Population
    American Journal of PharmacoGenomics, vol. 5, no. 2, pp. 123–131, 2005
  101. Therapeutic drug monitoring of non-anticancer drugs in cancer patients
    Methods and Findings in Experimental and Clinical Pharmacology, vol. 26, no. 7, p. 531, 2004
  102. A Phase I and Pharmacological Study of the Platinum Polymer AP5280 Given as an Intravenous Infusion Once Every 3 Weeks in Patients with Solid Tumors
    Clinical Cancer Research, vol. 10, no. 10, pp. 3386–3395, 2004
  103. The Effect of Food on the Pharmacokinetics of S-1 after Single Oral Administration to Patients with Solid Tumors
    Clinical Cancer Research, vol. 10, no. 12, pp. 4072–4076, 2004
  104. Mechanism of the Pharmacokinetic Interaction between Methotrexate and Benzimidazoles: Potential Role for Breast Cancer Resistance Protein in Clinical Drug-Drug Interactions
    Cancer Research, vol. 64, no. 16, pp. 5804–5811, 2004
  105. Platinated DNA Adducts Enhance Poisoning of DNA Topoisomerase I by Camptothecin
    Journal of Biological Chemistry, vol. 279, no. 52, pp. 54502–54509, 2004
  106. Bayesian Pharmacokinetically Guided Dosing of Paclitaxel in Patients with Non-Small Cell Lung Cancer
    Clinical Cancer Research, vol. 10, no. 7, pp. 2237–2244, 2004
  107. A Phase I and Pharmacological Study with Imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a Novel Ruthenium Anticancer Agent
    Clinical Cancer Research, vol. 10, no. 11, pp. 3717–3727, 2004
  108. Phase I Study of Docetaxel in Combination with the P-Glycoprotein Inhibitor, Zosuquidar, in Resistant Malignancies
    Clinical Cancer Research, vol. 10, no. 21, pp. 7220–7228, 2004
  109. Drug interactions in oncology
    The Lancet Oncology, vol. 5, no. 8, pp. 489–496, 2004
  110. Drug-Drug Interaction between Itraconazole and the Antiretroviral Drug Lopinavir/Ritonavir in an HIV-1-Infected Patient with Disseminated Histoplasmosis
    Clinical Infectious Diseases, vol. 38, no. 8, pp. e73–e75, 2004
  111. Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice
    Investigational New Drugs, vol. 22, no. 3, pp. 219–229, 2004
  112. A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer
    British Journal of Cancer, Article ID 6602172, 2004
  113. In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug
    Investigational New Drugs, vol. 22, no. 3, pp. 241–251, 2004
  114. Pharmacokinetic Drug–Drug Interaction of the Novel Anticancer Agent E7070 and Acenocoumarol
    Investigational New Drugs, vol. 22, no. 2, pp. 151–158, 2004
  115. No topoisomerase I alteration in a neuroblastoma model with in vivo acquired resistance to irinotecan
    British Journal of Cancer, Article ID 6602079, 2004
  116. Isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: recent trends and perspectives
    European Journal of Cancer, vol. 40, no. 12, pp. 1812–1824, 2004
  117. Development and validation of a method to determine the unbound paclitaxel fraction in human plasma
    Analytical Biochemistry, vol. 324, no. 1, pp. 11–15, 2004
  118. Systemic and tumor disposition of platinum after administration of cisplatin or STEALTH liposomal-cisplatin formulations (SPI-077 and SPI-077 B103) in a preclinical tumor model of melanoma
    Cancer Chemotherapy and Pharmacology, vol. 53, no. 4, pp. 329–336, 2004
  119. Quantitative analysis of the novel anticancer drug ABT-518, a matrix metalloproteinase inhibitor, plus the screening of six metabolites in human plasma using high-performance liquid chromatography coupled with electrospray tandem mass spectrometry
    Journal of Mass Spectrometry, vol. 39, no. 3, pp. 277–288, 2004
  120. Cytotoxicity of the organic ruthenium anticancer drug Nami-A is correlated with DNA binding in four different human tumor cell lines
    Cancer Chemotherapy and Pharmacology, vol. 54, no. 1, pp. 71–78, 2004
  121. Oral bioavailability of docetaxel in combination with OC144-093 (ONT-093)
    Cancer Chemotherapy and Pharmacology, vol. 55, no. 1, pp. 72–78, 2004
  122. Phase I study of an oral formulation of irinotecan administered daily for 14?days every 3?weeks in patients with advanced solid tumours
    Cancer Chemotherapy and Pharmacology, vol. 55, no. 3, pp. 263–270, 2004
  123. Quantitative analysis of the P-glycoprotein inhibitor Elacridar (GF120918) in human and dog plasma using liquid chromatography with tandem mass spectrometric detection
    Journal of Mass Spectrometry, vol. 39, no. 10, pp. 1122–1130, 2004
  124. Quantitative determination of the novel anticancer drug E7070 (indisulam) and its metabolite (1,4-benzenedisulphonamide) in human plasma, urine and faeces by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 18, no. 23, pp. 2839–2848, 2004
  125. Quantitative analysis of D-24851, a novel anticancer agent, in human plasma and urine by liquid chromatography coupled with tandem mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 18, no. 13, pp. 1465–1471, 2004
  126. A more sensitive MS detector does not obviously lead to a more sensitive assay: experiences with ES-285
    Biomedical Chromatography, vol. 18, no. 6, pp. 403–407, 2004
  127. Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F signi?cantly improves assay performance
    Biomedical Chromatography, vol. 18, no. 6, pp. 400–402, 2004
  128. Liquid chromatographic assay for the cyclic depsipeptide aplidine, a new marine antitumor drug, in whole blood using derivatization withtrans-4'-hydrazino-2-stilbazole
    Biomedical Chromatography, vol. 18, no. 1, pp. 16–20, 2004
  129. Simple high-performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue
    Biomedical Chromatography, vol. 17, no. 7, pp. 458–464, 2003
  130. Quantitative analysis of ES-285, an investigational marine anticancer drug, in human, mouse, rat, and dog plasma using coupled liquid chromatography and tandem mass spectrometry
    Journal of Mass Spectrometry, vol. 38, no. 5, pp. 548–554, 2003
  131. An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons
    Toxicology and Applied Pharmacology, vol. 189, no. 3, pp. 233–246, 2003
  132. Investigational New Drugs, vol. 21, no. 2, pp. 225–241, 2003
  133. Liquid chromatographic assay for the antiviral nucleotide analogue tenofovir in plasma using derivatization with chloroacetaldehyde
    Journal of Chromatography B, vol. 791, no. 1-2, pp. 227–233, 2003
  134. DNA repair mechanisms involved in gemcitabine cytotoxicity and in the interaction between gemcitabine and cisplatin
    Biochemical Pharmacology, vol. 65, no. 2, pp. 275–282, 2003
  135. Phase I clinical and pharmacokinetic study of E7070, a novel sulfonamide given as a 5-day continuous infusion repeated every 3 weeks in patients with solid tumours. A study by the EORTC Early Clinical Study Group (ECSG)
    European Journal of Cancer, vol. 39, no. 8, pp. 1097–1104, 2003
  136. Phase II trial with S-1 in chemotherapy-naïve patients with gastric cancer. A trial performed by the EORTC Early Clinical Studies Group (ECSG)
    European Journal of Cancer, vol. 39, no. 9, pp. 1264–1270, 2003
  137. EORTC Early Clinical Studies Group early phase II trial of S-1 in patients with advanced or metastatic colorectal cancer
    British Journal of Cancer, vol. 88, no. 5, Article ID 6600781, 5 pages, 2003
  138. Adaptive intrapatient dose escalation of cisplatin in combination with low-dose vp16 in patients with nonsmall cell lung cancer
    British Journal of Cancer, vol. 88, no. 6, Article ID 6600794, 7 pages, 2003
  139. A population pharmacokinetic model for paclitaxel in the presence of a novel P-gp modulator, Zosuquidar Trihydrochloride (LY335979)
    British Journal of Clinical Pharmacology, vol. 56, no. 1, pp. 46–56, 2003
  140. Erratum
    British Journal of Clinical Pharmacology, vol. 56, no. 4, pp. 463–463, 2003
  141. Evidence for Two Interacting Ligand Binding Sites in Human Multidrug Resistance Protein 2 (ATP Binding Cassette C2)
    Journal of Biological Chemistry, vol. 278, no. 26, pp. 23538–23544, 2003
  142. Weekly oral paclitaxel as first-line treatment in patients with advanced gastric cancer
    Annals of Oncology, vol. 14, no. 2, pp. 197–204, 2003