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Jan H.M. Schellens
Articles in Scholarly Journals [Incomplete List]
Determination of ruthenium originating from the investigational anti-cancer drug NAMI-A in human plasma ultrafiltrate, plasma, and urine by inductively coupled plasma mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 21, no. 9, pp. 1521–1530, 2007
Liquid chromatography–tandem mass spectrometric assay for the nucleoside reverse transcriptase inhibitor emtricitabine in human plasma
Biomedical Chromatography, vol. 21, no. 6, pp. 621–627, 2007
Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 21, no. 14, pp. 2312–2322, 2007
Severe pulmonary toxicity in patients with leiomyosarcoma after treatment with gemcitabine and docetaxel
Investigational New Drugs, vol. 25, no. 3, pp. 279–281, 2007
Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry
Investigational New Drugs, vol. 25, no. 4, pp. 327–334, 2007
Determination of imatinib mesylate and its main metabolite (CGP74588) in human plasma and murine specimens by ion-pairing reversed-phase high-performance liquid chromatography
Biomedical Chromatography, vol. 21, no. 7, pp. 747–754, 2007
Novel paclitaxel formulations for oral application: a phase I pharmacokinetic study in patients with solid tumours
Cancer Chemotherapy and Pharmacology, vol. 60, no. 5, pp. 635–642, 2007
Is rectal administration an alternative route for imatinib?
Cancer Chemotherapy and Pharmacology, vol. 60, no. 4, pp. 623–624, 2007
Monitoring of platinum surface contamination in seven Dutch hospital pharmacies using inductively coupled plasma mass spectrometry
International Archives of Occupational and Environmental Health, vol. 80, no. 8, pp. 689–699, 2007
The role of nuclear receptors in pharmacokinetic drug–drug interactions in oncology
Cancer Treatment Reviews, vol. 33, no. 4, pp. 369–380, 2007
Phase I and pharmacokinetic trial of AP5346, a DACH–platinum–polymer conjugate, administered weekly for three out of every 4 weeks to advanced solid tumor patients
Cancer Chemotherapy and Pharmacology, vol. 60, no. 4, pp. 523–533, 2007
Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy
Cancer Treatment Reviews, vol. 33, no. 2, pp. 191–202, 2007
Enzymatic digestion as a tool for the LC–MS/MS quantification of large peptides in biological matrices: Measurement of chymotryptic fragments from the HIV-1 fusion inhibitor enfuvirtide and its metabolite M-20 in human plasma
Journal of Chromatography B, vol. 854, no. 1-2, pp. 245–259, 2007
Liquid chromatography–tandem mass spectrometric assays for salinomycin in mouse plasma, liver, brain and small intestinal contents and in OptiMEM cell culture medium
Journal of Chromatography B, vol. 855, no. 2, pp. 200–210, 2007
Stability experiments in human urine with EO9 (apaziquone): A novel anticancer agent for the intravesical treatment of bladder cancer
Journal of Pharmaceutical and Biomedical Analysis, vol. 43, no. 1, pp. 285–292, 2007
Validation of SELDI-TOF MS serum protein profiles for renal cell carcinoma in new populations
Laboratory Investigation, vol. 87, no. 2, Article ID 3700503, 11 pages, 2007
Pharmacogenetic Screening of the Gene Deletion and Duplications of CYP2D6
Drug Metabolism Reviews, vol. 39, no. 1, pp. 45–60, 2007
Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral Protein Kinase C -Inhibitor Enzastaurin in Combination with Gemcitabine and Cisplatin in Patients with Advanced Cancer
Clinical Cancer Research, vol. 13, no. 15, pp. 4474–4481, 2007
CYP2C9 and CYP2C19 Polymorphic Forms Are Related to Increased Indisulam Exposure and Higher Risk of Severe Hematologic Toxicity
Clinical Cancer Research, vol. 13, no. 10, pp. 2970–2976, 2007
A Phase I, Randomized, Open-Label, Parallel-Cohort, Dose-Finding Study of Elacridar (GF120918) and Oral Topotecan in Cancer Patients
Clinical Cancer Research, vol. 13, no. 11, pp. 3276–3285, 2007
Phase I Pharmacokinetic Study of the Safety and Tolerability of Lapatinib (GW572016) in Combination with Oxaliplatin/Fluorouracil/Leucovorin (FOLFOX4) in Patients with Solid Tumors
Clinical Cancer Research, vol. 13, no. 15, pp. 4495–4502, 2007
A Phase I Safety and Pharmacologic Study of a Twice Weekly Dosing Regimen of the Oral Taxane BMS-275183
Clinical Cancer Research, vol. 13, no. 13, pp. 3906–3912, 2007
Capecitabine
The Oncologist, vol. 12, no. 2, pp. 152–155, 2007
Clinical and Pharmacologic Study of the Farnesyltransferase Inhibitor Tipifarnib in Cancer Patients With Normal or Mildly or Moderately Impaired Hepatic Function
Journal of Clinical Oncology, vol. 24, no. 28, pp. 4558–4564, 2006
Genetic Polymorphisms of Drug Metabolising Enzymes and Drug Transporters in Relation to Cancer Risk
Current Cancer Therapy Reviews, vol. 2, no. 2, pp. 137–155, 2006
Determinants of the elimination of methotrexate and 7-hydroxy-methotrexate following high-dose infusional therapy to cancer patients
British Journal of Clinical Pharmacology, vol. 62, no. 1, pp. 71–80, 2006
Symptoms and Treatment in Cancer Therapy-Induced Early Menopause
The Oncologist, vol. 11, no. 6, pp. 641–654, 2006
Herb-Drug Interactions in Oncology: Focus on Mechanisms of Induction
The Oncologist, vol. 11, no. 7, pp. 742–752, 2006
Photodynamic Therapy in Oncology
The Oncologist, vol. 11, no. 9, pp. 1034–1044, 2006
Saturable binding of indisulam to plasma proteins and distribution to human erythrocytes
Drug Metabolism and Disposition, 2006
Relationship Between Cisplatin Administration and the Development of Ototoxicity
Journal of Clinical Oncology, vol. 24, no. 6, pp. 918–924, 2006
Dose-Finding Phase I Clinical and Pharmacokinetic Study of Orally Administered Irinotecan in Patients with Advanced Solid Tumors
Clinical Cancer Research, vol. 12, no. 12, pp. 3774–3781, 2006
Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs
Trends in Pharmacological Sciences, vol. 27, no. 1, pp. 17–24, 2006
The Effect of Low pH on Breast Cancer Resistance Protein (ABCG2)-Mediated Transport of Methotrexate, 7-Hydroxymethotrexate, Methotrexate Diglutamate, Folic Acid, Mitoxantrone, Topotecan, and Resveratrol in In Vitro Drug Transport Models
Molecular Pharmacology, vol. 71, no. 1, pp. 240–249, 2006
Mass Balance Studies, with a Focus on Anticancer Drugs
Clinical Pharmacokinetics, vol. 45, no. 1, pp. 33–58, 2006
Genetic Polymorphisms of Drug-Metabolising Enzymes and Drug Transporters in the Chemotherapeutic Treatment of Cancer
Clinical Pharmacokinetics, vol. 45, no. 3, pp. 253–285, 2006
Pharmacogenetic Screening of CYP3A and ABCB1 in Relation to Population Pharmacokinetics of Docetaxel
Clinical Cancer Research, vol. 12, no. 19, pp. 5786–5793, 2006
Flat Dosing of Carboplatin Is Justified in Adult Patients with Normal Renal Function
Clinical Cancer Research, vol. 12, no. 21, pp. 6502–6508, 2006
Interactions of Serum Albumin, Valproic Acid and Carbamazepine with the Pharmacokinetics of Phenytoin in Cancer Patients
Basic
Clinical Pharmacology
Toxicology, vol. 99, no. 2, pp. 133–140, 2006
Analytical Chemistry, vol. 78, no. 8, pp. 2617–2622, 2006
Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei
Nucleic Acids Research, vol. 34, no. 6, pp. e47–e47, 2006
Carcinogen and Anticancer Drug Transport by Mrp2 in Vivo: Studies Using Mrp2 (Abcc2) Knockout Mice
Journal of Pharmacology and Experimental Therapeutics, vol. 318, no. 1, pp. 319–327, 2006
Radiosensitization of Squamous Cell Carcinoma by the Alkylphospholipid Perifosine in Cell Culture and Xenografts
Clinical Cancer Research, vol. 12, no. 5, pp. 1615–1622, 2006
Quantitative Effect of Gender, Age, Liver Function, and Body Size on the Population Pharmacokinetics of Paclitaxel in Patients with Solid Tumors
Clinical Cancer Research, vol. 12, no. 7, pp. 2150–2157, 2006
A novel self-microemulsifying formulation of paclitaxel for oral administration to patients with advanced cancer
British Journal of Cancer, vol. 95, no. 6, Article ID 6603312, 5 pages, 2006
Phase II and pharmacological study of oral paclitaxel (Paxoral) plus ciclosporin in anthracycline-pretreated metastatic breast cancer
British Journal of Cancer, vol. 95, no. 7, Article ID 6603332, 6 pages, 2006
Clinical proteomics: searching for better tumour markers with SELDI-TOF mass spectrometry
Trends in Pharmacological Sciences, vol. 27, no. 5, pp. 251–259, 2006
Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours
Radiotherapy and Oncology, vol. 80, no. 2, pp. 207–213, 2006
Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry
Analytical Biochemistry, vol. 352, no. 1, pp. 33–40, 2006
Future opportunities in preventing cisplatin induced ototoxicity
Cancer Treatment Reviews, vol. 32, no. 5, pp. 390–397, 2006
Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines
Toxicology and Applied Pharmacology, vol. 211, no. 1, pp. 1–10, 2006
Screening for polymorphisms in the PXR gene in a Dutch population
European Journal of Clinical Pharmacology, vol. 62, no. 5, pp. 395–399, 2006
A Semi-Physiological Population Pharmacokinetic Model Describing the Non-linear Disposition of Indisulam
Journal of Pharmacokinetics and Pharmacodynamics, vol. 33, no. 5, pp. 543–570, 2006
Metabolism of trabectedin (ET-743, Yondelis™) in patients with advanced cancer
Cancer Chemotherapy and Pharmacology, vol. 59, no. 6, pp. 825–837, 2006
The pharmacokinetic behavior of the photosensitizer meso-tetra-hydroxyphenyl-chlorin in mice and men
Cancer Chemotherapy and Pharmacology, vol. 60, no. 1, pp. 113–122, 2006
A pharmacokinetic and safety study of a novel polymeric paclitaxel formulation for oral application
Cancer Chemotherapy and Pharmacology, vol. 59, no. 1, pp. 43–50, 2006
Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers
European Journal of Clinical Pharmacology, vol. 62, no. 8, pp. 681–684, 2006
Liquid chromatography–tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and ß-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes?
Journal of Chromatography B, vol. 839, no. 1-2, pp. 45–53, 2006
Development and validation of a quantitative assay for the measurement of two HIV-fusion inhibitors, enfuvirtide and tifuvirtide, and one metabolite of enfuvirtide (M-20) in human plasma by liquid chromatography–tandem mass spectrometry
Journal of Chromatography B, vol. 837, no. 1-2, pp. 49–58, 2006
Trabectedin (ET-743, Yondelis™) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype
Investigational New Drugs, vol. 25, no. 1, pp. 1–7, 2006
Phase I dose-finding and pharmacokinetic trial of orally administered indibulin (D-24851) to patients with solid tumors
Investigational New Drugs, vol. 25, no. 3, pp. 227–235, 2006
In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis®, Trabectidin®), a novel marine anti-cancer drug
Investigational New Drugs, vol. 24, no. 1, pp. 3–14, 2006
In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug
Investigational New Drugs, vol. 25, no. 1, pp. 9–19, 2006
The effect of hydroxyurea on P-glycoprotein/BCRP-mediated transport and CYP3A metabolism of imatinib mesylate
Cancer Chemotherapy and Pharmacology, vol. 59, no. 6, pp. 855–860, 2006
Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry
Journal of Mass Spectrometry, vol. 41, no. 12, pp. 1633–1642, 2006
Sensitive inductively coupled plasma mass spectrometry assay for the determination of platinum originating from cisplatin, carboplatin, and oxaliplatin in human plasma ultrafiltrate
Journal of Mass Spectrometry, vol. 41, no. 9, pp. 1186–1194, 2006
Quantitative analysis of EO9 (apaziquone) and its metabolite EO5a in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray tandem mass spectrometry
Journal of Mass Spectrometry, vol. 41, no. 10, pp. 1268–1276, 2006
Prediction of treatment outcome by cisplatin-DNA adduct formation in patients with stage III/IV head and neck squamous cell carcinoma, treated by concurrent cisplatin-radiation (RADPLAT)
International Journal of Cancer, vol. 119, no. 4, pp. 750–756, 2006
Liquid chromatographic assay for the non-peptidic protease inhibitor tipranavir in plasma
Biomedical Chromatography, vol. 20, no. 8, pp. 671–673, 2006
A rapid and simple HPLC-UV method for the determination of inhibition characteristics of farnesyl transferase inhibitors
Biomedical Chromatography, vol. 20, no. 2, pp. 161–165, 2006
A simple and sensitive assay for the quantitative analysis of paclitaxel and metabolites in human plasma using liquid chromatography/tandem mass spectrometry
Biomedical Chromatography, vol. 20, no. 1, pp. 139–148, 2005
Liquid chromatographic assay for the protease inhibitor atazanavir in plasma
Biomedical Chromatography, vol. 20, no. 1, pp. 72–76, 2005
Quantitative analysis of docetaxel in human plasma using liquid chromatography coupled with tandem mass spectrometry
Biomedical Chromatography, vol. 19, no. 5, pp. 355–361, 2005
Determination of oxaliplatin in human plasma and plasma ultrafiltrate by graphite-furnace atomic-absorption spectrometry
Analytical and Bioanalytical Chemistry, vol. 382, no. 7, pp. 1484–1490, 2005
Quantitative analysis of the farnesyl transferase inhibitor lonafarnib (Sarasar™, SCH66336) in human plasma using high-performance liquid chromatography coupled with tandem mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 19, no. 15, pp. 2187–2192, 2005
Structure elucidation of aplidine metabolites formedin vitro by human liver microsomes using triple quadrupole mass spectrometry
Journal of Mass Spectrometry, vol. 40, no. 6, pp. 821–831, 2005
Pharmacokinetics of low-dose doxorubicin and metabolites in patients with AIDS-related Kaposi sarcoma
Cancer Chemotherapy and Pharmacology, vol. 55, no. 5, pp. 488–496, 2005
Metabolism of docetaxel in mice
Cancer Chemotherapy and Pharmacology, vol. 56, no. 3, pp. 299–306, 2005
Absence of N-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP/ABCG2)
Cancer Chemotherapy and Pharmacology, vol. 56, no. 4, pp. 344–350, 2005
Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid
Investigational New Drugs, vol. 23, no. 4, pp. 279–286, 2005
Human metabolism of [14C]indisulam following i.v. infusion in cancer patients
Investigational New Drugs, vol. 23, no. 4, pp. 317–330, 2005
Trabectedin (YondelisTM, formerly ET-743), a mass balance study in patients with advanced cancer
Investigational New Drugs, vol. 23, no. 5, pp. 429–436, 2005
Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam
Investigational New Drugs, vol. 23, no. 3, pp. 225–234, 2005
Hepatotoxicity and metabolism of trabectedin: a literature review
Pharmacological Research, 2005
Chronic hepatotoxicity after long-term antiretroviral treatment including nevirapine
Journal of Infection, vol. 50, no. 3, pp. 262–264, 2005
Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra®, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumours
British Journal of Cancer, vol. 93, no. 11, Article ID 6602850, 7 pages, 2005
Modulation of Oral Drug Bioavailability: From Preclinical Mechanism to Therapeutic Application
Cancer Investigation, vol. 23, no. 5, pp. 443–464, 2005
No pharmacokinetic drug???drug interaction between nevirapine and paclitaxel
Anti-Cancer Drugs, vol. 16, no. 6, pp. 627–630, 2005
Breast Cancer Resistance Protein (Bcrp1/Abcg2) Limits Net Intestinal Uptake of Quercetin in Rats by Facilitating Apical Efflux of Glucuronides
Molecular Pharmacology, vol. 67, no. 6, pp. 1999–2006, 2005
Phase I Clinical and Pharmacokinetic Study of Kahalalide F in Patients with Advanced Androgen Refractory Prostate Cancer
Clinical Cancer Research, vol. 11, no. 5, pp. 1854–1862, 2005
Phase I clinical and pharmacologic study of a 2-weekly administration of cisplatin and gemcitabine in patients with advanced non-small cell lung cancer
Anti-Cancer Drugs, vol. 16, no. 9, pp. 1029–1036, 2005
In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction
Anti-Cancer Drugs, vol. 16, no. 9, pp. 935–943, 2005
Population pharmacokinetics of orally administered paclitaxel formulated in Cremophor EL
British Journal of Clinical Pharmacology, vol. 59, no. 3, pp. 325–334, 2005
Development of Farnesyl Transferase Inhibitors: A Review
The Oncologist, vol. 10, no. 8, pp. 565–578, 2005
Current Knowledge and Future Directions of the Selective Epidermal Growth Factor Receptor Inhibitors Erlotinib (Tarceva(R)) and Gefitinib (Iressa(R))
The Oncologist, vol. 10, no. 8, pp. 579–589, 2005
Cannulation of the jugular vein in mice
Laboratory Animals, vol. 39, no. 1, pp. 130–132, 2005
MIDAZOLAM AND CYCLOSPORIN A METABOLISM IN TRANSGENIC MICE WITH LIVER-SPECIFIC EXPRESSION OF HUMAN CYP3A4
Drug Metabolism and Disposition, vol. 33, no. 7, pp. 892–895, 2005
The Effect of Bcrp1 (Abcg2) on the In vivo Pharmacokinetics and Brain Penetration of Imatinib Mesylate (Gleevec): Implications for the Use of Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors to Enable the Brain Penetration of Imatinib in Patients
Cancer Research, vol. 65, no. 7, pp. 2577–2582, 2005
Individualised Cancer Chemotherapy: Strategies and Performance of Prospective Studies on Therapeutic Drug Monitoring with Dose Adaptation
Clinical Pharmacokinetics, vol. 44, no. 2, pp. 147–173, 2005
Detection of Single Nucleotide Polymorphisms in the ABCG2 Gene in a Dutch Population
American Journal of PharmacoGenomics, vol. 5, no. 2, pp. 123–131, 2005
Therapeutic drug monitoring of non-anticancer drugs in cancer patients
Methods and Findings in Experimental and Clinical Pharmacology, vol. 26, no. 7, p. 531, 2004
A Phase I and Pharmacological Study of the Platinum Polymer AP5280 Given as an Intravenous Infusion Once Every 3 Weeks in Patients with Solid Tumors
Clinical Cancer Research, vol. 10, no. 10, pp. 3386–3395, 2004
The Effect of Food on the Pharmacokinetics of S-1 after Single Oral Administration to Patients with Solid Tumors
Clinical Cancer Research, vol. 10, no. 12, pp. 4072–4076, 2004
Mechanism of the Pharmacokinetic Interaction between Methotrexate and Benzimidazoles: Potential Role for Breast Cancer Resistance Protein in Clinical Drug-Drug Interactions
Cancer Research, vol. 64, no. 16, pp. 5804–5811, 2004
Platinated DNA Adducts Enhance Poisoning of DNA Topoisomerase I by Camptothecin
Journal of Biological Chemistry, vol. 279, no. 52, pp. 54502–54509, 2004
Bayesian Pharmacokinetically Guided Dosing of Paclitaxel in Patients with Non-Small Cell Lung Cancer
Clinical Cancer Research, vol. 10, no. 7, pp. 2237–2244, 2004
A Phase I and Pharmacological Study with Imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a Novel Ruthenium Anticancer Agent
Clinical Cancer Research, vol. 10, no. 11, pp. 3717–3727, 2004
Phase I Study of Docetaxel in Combination with the P-Glycoprotein Inhibitor, Zosuquidar, in Resistant Malignancies
Clinical Cancer Research, vol. 10, no. 21, pp. 7220–7228, 2004
Drug interactions in oncology
The Lancet Oncology, vol. 5, no. 8, pp. 489–496, 2004
Drug-Drug Interaction between Itraconazole and the Antiretroviral Drug Lopinavir/Ritonavir in an HIV-1-Infected Patient with Disseminated Histoplasmosis
Clinical Infectious Diseases, vol. 38, no. 8, pp. e73–e75, 2004
Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice
Investigational New Drugs, vol. 22, no. 3, pp. 219–229, 2004
A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer
British Journal of Cancer, Article ID 6602172, 2004
In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug
Investigational New Drugs, vol. 22, no. 3, pp. 241–251, 2004
Pharmacokinetic Drug–Drug Interaction of the Novel Anticancer Agent E7070 and Acenocoumarol
Investigational New Drugs, vol. 22, no. 2, pp. 151–158, 2004
No topoisomerase I alteration in a neuroblastoma model with in vivo acquired resistance to irinotecan
British Journal of Cancer, Article ID 6602079, 2004
Isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: recent trends and perspectives
European Journal of Cancer, vol. 40, no. 12, pp. 1812–1824, 2004
Development and validation of a method to determine the unbound paclitaxel fraction in human plasma
Analytical Biochemistry, vol. 324, no. 1, pp. 11–15, 2004
Systemic and tumor disposition of platinum after administration of cisplatin or STEALTH liposomal-cisplatin formulations (SPI-077 and SPI-077 B103) in a preclinical tumor model of melanoma
Cancer Chemotherapy and Pharmacology, vol. 53, no. 4, pp. 329–336, 2004
Quantitative analysis of the novel anticancer drug ABT-518, a matrix metalloproteinase inhibitor, plus the screening of six metabolites in human plasma using high-performance liquid chromatography coupled with electrospray tandem mass spectrometry
Journal of Mass Spectrometry, vol. 39, no. 3, pp. 277–288, 2004
Cytotoxicity of the organic ruthenium anticancer drug Nami-A is correlated with DNA binding in four different human tumor cell lines
Cancer Chemotherapy and Pharmacology, vol. 54, no. 1, pp. 71–78, 2004
Oral bioavailability of docetaxel in combination with OC144-093 (ONT-093)
Cancer Chemotherapy and Pharmacology, vol. 55, no. 1, pp. 72–78, 2004
Phase I study of an oral formulation of irinotecan administered daily for 14?days every 3?weeks in patients with advanced solid tumours
Cancer Chemotherapy and Pharmacology, vol. 55, no. 3, pp. 263–270, 2004
Quantitative analysis of the P-glycoprotein inhibitor Elacridar (GF120918) in human and dog plasma using liquid chromatography with tandem mass spectrometric detection
Journal of Mass Spectrometry, vol. 39, no. 10, pp. 1122–1130, 2004
Quantitative determination of the novel anticancer drug E7070 (indisulam) and its metabolite (1,4-benzenedisulphonamide) in human plasma, urine and faeces by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 18, no. 23, pp. 2839–2848, 2004
Quantitative analysis of D-24851, a novel anticancer agent, in human plasma and urine by liquid chromatography coupled with tandem mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 18, no. 13, pp. 1465–1471, 2004
A more sensitive MS detector does not obviously lead to a more sensitive assay: experiences with ES-285
Biomedical Chromatography, vol. 18, no. 6, pp. 403–407, 2004
Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F signi?cantly improves assay performance
Biomedical Chromatography, vol. 18, no. 6, pp. 400–402, 2004
Liquid chromatographic assay for the cyclic depsipeptide aplidine, a new marine antitumor drug, in whole blood using derivatization withtrans-4'-hydrazino-2-stilbazole
Biomedical Chromatography, vol. 18, no. 1, pp. 16–20, 2004
Simple high-performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue
Biomedical Chromatography, vol. 17, no. 7, pp. 458–464, 2003
Quantitative analysis of ES-285, an investigational marine anticancer drug, in human, mouse, rat, and dog plasma using coupled liquid chromatography and tandem mass spectrometry
Journal of Mass Spectrometry, vol. 38, no. 5, pp. 548–554, 2003
An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons
Toxicology and Applied Pharmacology, vol. 189, no. 3, pp. 233–246, 2003
Investigational New Drugs, vol. 21, no. 2, pp. 225–241, 2003
Liquid chromatographic assay for the antiviral nucleotide analogue tenofovir in plasma using derivatization with chloroacetaldehyde
Journal of Chromatography B, vol. 791, no. 1-2, pp. 227–233, 2003
DNA repair mechanisms involved in gemcitabine cytotoxicity and in the interaction between gemcitabine and cisplatin
Biochemical Pharmacology, vol. 65, no. 2, pp. 275–282, 2003
Phase I clinical and pharmacokinetic study of E7070, a novel sulfonamide given as a 5-day continuous infusion repeated every 3 weeks in patients with solid tumours. A study by the EORTC Early Clinical Study Group (ECSG)
European Journal of Cancer, vol. 39, no. 8, pp. 1097–1104, 2003
Phase II trial with S-1 in chemotherapy-naïve patients with gastric cancer. A trial performed by the EORTC Early Clinical Studies Group (ECSG)
European Journal of Cancer, vol. 39, no. 9, pp. 1264–1270, 2003
EORTC Early Clinical Studies Group early phase II trial of S-1 in patients with advanced or metastatic colorectal cancer
British Journal of Cancer, vol. 88, no. 5, Article ID 6600781, 5 pages, 2003
Adaptive intrapatient dose escalation of cisplatin in combination with low-dose vp16 in patients with nonsmall cell lung cancer
British Journal of Cancer, vol. 88, no. 6, Article ID 6600794, 7 pages, 2003
A population pharmacokinetic model for paclitaxel in the presence of a novel P-gp modulator, Zosuquidar Trihydrochloride (LY335979)
British Journal of Clinical Pharmacology, vol. 56, no. 1, pp. 46–56, 2003
Erratum
British Journal of Clinical Pharmacology, vol. 56, no. 4, pp. 463–463, 2003
Evidence for Two Interacting Ligand Binding Sites in Human Multidrug Resistance Protein 2 (ATP Binding Cassette C2)
Journal of Biological Chemistry, vol. 278, no. 26, pp. 23538–23544, 2003
Weekly oral paclitaxel as first-line treatment in patients with advanced gastric cancer
Annals of Oncology, vol. 14, no. 2, pp. 197–204, 2003