Kalman Magyar finished his university studies in 1959 at the Faculty of Medicine of the Semmelweis University, Budapest, Hungary. He was immediately employed as a university teacher at the Department of Pharmacology. From 1979 to 1998, he was the Head of the Department of Pharmacodynamics, Faculty of Pharmacy. From 1961 to 1962, he was working in London at the MRC Neurochemical Research Unit having a Riker fellowship. In 1978, he received the D.S. degree. In 1987, he was elected as a Member of the Hungarian Academy of Sciences. Presently, he is Professor Emeritus of the Semmelweis University. His main scientific interests are biochemical pharmacology, pharmacokinetic, and pharmacodynamic studies of drugs. His main research activities are connected to the study of the mode of action (-)-deprenyl, the selective inhibitor of MAO-B, which was and still is used to treat Parkinson’s disease. Beside MAO-B inhibition, deprenyl in low concentrations (<10-9 M) inhibits apoptosis and increases production of the proapoptotic factors. The MAO-B inhibitor has an intensive first pass metabolism, and the metabolites take part in the complex pharmacological activity of the drug. In addition to deprenyl, many other original Hungarian compounds have been investigated in his laboratory (e.g., deramciclane, No-Spa, Probon). Bioequivalent studies were also carried out under his scientific guidance.
Biography Updated on 23 February 2011