M. Smith is a Professor of pathology at Case Western Reserve University, Cleveland, Ohio, USA. He received a B.S. degree in molecular biology and biochemistry from Hatfield College, Durham University, England (1986) and a Ph.D. degree in biochemistry from Nottingham University, England (1990). Following a research fellowship at Sandoz Forschungsinstitut, Vienna, Austria, Dr. Smith joined Case Western Reserve University (CWRU) in 1992. The focus of Dr. Smith’s research involves investigating the pathological mechanism(s) underlying selective neuronal death in neurodegenerative diseases such as Alzheimer’s disease. Dr. Smith’s research involves a variety of techniques ranging from histological to molecular biology to cellular models. The major hypothesis being pursued is that oxidative stress plays a pivotal role in disease pathogenesis. Therefore, his current work is directed towards elucidating triggers of oxidative stress including (1) fundamental metabolic alterations, (2) homeostatic dysregulation of transition metals, (3) signal transduction alterations, and (4) inappropriate re-entry into the cell cycle. Dr. Smith has authored over 600 peer-reviewed manuscripts and chapters. He is also the recipient of several awards including the Ruth Salta Junior Investigator Achievement Award from the American Health Assistance Foundation, Young Scientist Lectureship Award from the International Society for Neurochemistry, the Nathan Shock New Investigator Award from The Gerontological Society of America, the Zenith Award from the Alzheimer's Association, the Jordi Folch-Pi Award from the American Society of Neurochemistry, and the Esterbauer Award from the HNE Society.
Biography Updated on 23 January 2011