Nicola Zambrano was born in 1963 (Mercato San Severino, Italy). He earned the Laurea degree magna cum laude in biological sciences (1987, University of Naples Federico II, Italy) and the Ph.D. in biotechnology (1995, University of L’Aquila, Italy). He served as an Assistant Professor of biochemistry (1996-2002), as an Associate Professor (2002-2010), and then as a Full Professor of molecular biology, University of Naples Federico II. As a Fellow of the Italian Association for Cancer Research, between 1989 and 1991, he worked on regulation of gene expression. From 1991 to 1994, at the National Cancer Institute in Bethesda, USA, he worked as a visiting Fellow, working on structure-function relationship of the p53 tumor suppressor protein and on the HIVI nucleocapsid protein. During 1997, at the European Molecular Biology Laboratory (Heidelberg, Germany), he spent a period on gene-targeting technologies in the mouse. Since 1994, at the Department of Biochemistry and Medical Biotechnologies, the University of Naples Federico II, he participated in research projects leading to the identification of protein-protein interactions and signal transduction pathways, which contributed to the identification of various molecular complexes involving the Alzheimer's beta-amyloid precursor protein (APP) and the molecular adaptor Fe65. He also generated and analyzed animal models for the functional study of the Fe65/APP system in the mouse and in Caenorhabditis elegans. Currently, at the University of Naples Federico II and at CEINGE Biotecnologie Avanzate (Naples, Italy), his most recent interests deal with the use of proteomic approaches (analysis of differential expression and of interactomes) to identify and dissect functionally protein complexes involved in cell-cycle regulation, cellular proliferation and tumor resistance to biological drugs. He routinely acts as Reviewer of scientific projects for national and international agencies and charities.
Biography Updated on 14 June 2011