Michal Toborek

Michal Toborek received his M.D. degree in medicine from Silesian School of Medicine, Katowice, Poland, in 1985. He obtained his Ph.D. degree in biochemistry from Silesian School of Medicine, Katowice, Poland, in 1989. Between 1991 and 1995, he performed his postdoctoral studies at the University of Kentucky, Lexington, on nutrition/cell biology. Since 2005, he has been a Professor at the Department of Neurosurgery, University of Kentucky. He has also been an Associate Chair for research at the Department of Neurosurgery, University of Kentucky, since 2007, and a Professor at Graduate Center for Nutritional Sciences and Markey Cancer Center since 2005. Since 2004, he has been a Professor at the Department of Molecular and Cellular Biochemistry. He was awarded the Excellence in Research Award from the American Heart Association and Anafred N. Halpern Award from the American College of Nutrition in 1996. In 1998 and 2000, he recieved Alexander von Humboldt Research Awards, and in 2003 he was commissioned to the Honorable Order of Kentucky Colonel. During 2003–2007, he obtained Wethington Research Awards from the University of Kentucky. He is a Member of the Special Emphasis Study Sections ZRG1 AARR-D, ZAA1 BB, and ZMH1 ERB-S. He is also a Member of the Editorial Boards of Journal of Nutritional Biochemistry (Associate Editor); Journal of American College of Nutrition; Journal of Tissue Research; Current Nutrition and Food Science. He is also a Member of the American Heart Association, American Institute of Nutrition, American College of Nutrition, Society for Free Radical Research, International Brain Barriers Society (funding member).

Biography Updated on 2 April 2008

Articles in Scholarly Journals [Incomplete List]

  1. Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells
    Chemico-Biological Interactions, vol. 172, no. 1, pp. 27–38, 2008
  2. Impact of nutrition on PCB toxicity
    Environmental Toxicology and Pharmacology, vol. 25, no. 2, pp. 192–196, 2008
  3. Zinc nutritional status modulates expression of AhR-responsive P450 enzymes in vascular endothelial cells
    Environmental Toxicology and Pharmacology, vol. 25, no. 2, pp. 197–201, 2008
  4. PCBs and tight junction expression
    Environmental Toxicology and Pharmacology, vol. 25, no. 2, pp. 234–240, 2008
  5. Oral administration of PCBs induces proinflammatory and prometastatic responses
    Environmental Toxicology and Pharmacology, vol. 25, no. 2, pp. 251–259, 2008
  6. SIMVASTATIN PROTECTS AGAINST AMYLOID BETA AND HIV-1 TAT-INDUCED PROMOTER ACTIVITIES OF INFLAMMATORY GENES IN BRAIN ENDOTHELIAL CELLS
    Molecular Pharmacology, 2008
  7. The NMDA and AMPA/KA receptors are involved in glutamate-induced alterations of occludin expression and phosphorylation in brain endothelial cells
    Journal of Cerebral Blood Flow & Metabolism, vol. 27, no. 8, Article ID 9600445, 12 pages, 2007
  8. Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis
    Nutrition, Metabolism and Cardiovascular Diseases, vol. 17, no. 2, pp. 162–169, 2007
  9. Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of PI3K/Akt and ERK1/2 signaling
    The Journal of Nutritional Biochemistry, vol. 17, no. 11, pp. 766–772, 2006
  10. Macrophage migration inhibitory factor induces cell death and decreases neuronal nitric oxide expression in spinal cord neurons
    Neuroscience, vol. 139, no. 3, pp. 1117–1128, 2006
  11. c-Src Is the Primary Signaling Mediator of Polychlorinated Biphenyl-Induced Interleukin-8 Expression in a Human Microvascular Endothelial Cell Line
    Toxicological Sciences, vol. 92, no. 1, pp. 311–320, 2006
  12. Cyclooxygenase-2 is Involved in HIV-1 Tat-Induced Inflammatory Responses in the Brain
    NeuroMolecular Medicine, vol. 8, no. 3, pp. 337–352, 2006
  13. Modification of Environmental Toxicity by Nutrients: Implications in Atherosclerosis
    Cardiovascular Toxicology, vol. 5, no. 2, pp. 153–160, 2005
  14. HIV-Tat protein induces P-glycoprotein expression in brain microvascular endothelial cells
    Journal of Neurochemistry, vol. 93, no. 5, pp. 1231–1241, 2005
  15. Nicotine Attenuates Morphological Deficits in a Contusion Model of Spinal Cord Injury
    Journal of Neurotrauma, vol. 22, no. 2, pp. 240–251, 2005
  16. Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells
    Journal of Cerebral Blood Flow & Metabolism, vol. 25, no. 9, Article ID 9600115, 11 pages, 2005
  17. HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK1/2 activation
    Journal of Cerebral Blood Flow & Metabolism, vol. 25, no. 10, Article ID 9600125, 10 pages, 2005
  18. HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood–brain barrier
    Journal of Cerebral Blood Flow & Metabolism, vol. 26, no. 8, Article ID 9600254, 13 pages, 2005
  19. Proinflammatory synergism of ethanol and HIV-1 Tat protein in brain tissue
    Experimental Neurology, vol. 191, no. 1, pp. 2–12, 2005
  20. Human immunodeficiency virus-1 Tat protein up-regulates interleukin-6 and interleukin-8 expression in human breast cancer cells
    Inflammation Research, vol. 54, no. 9, pp. 380–389, 2005
  21. Mechanisms of the Blood–Brain Barrier Disruption in HIV-1 Infection
    Cellular and Molecular Neurobiology, vol. 25, no. 1, pp. 181–199, 2005
  22. Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells
    Cardiovascular Research, vol. 63, no. 1, pp. 139–148, 2004
  23. VEGF regulates PCB 104-mediated stimulation of permeability and transmigration of breast cancer cells in human microvascular endothelial cells
    Experimental Cell Research, vol. 296, no. 2, pp. 231–244, 2004
  24. Dietary Fat Interacts with PCBs to Induce Changes in Lipid Metabolism in LDL Receptor Deficient Mice
    Environmental Health Perspectives, 2004
  25. PCB 104-Induced Proinflammatory Reactions in Human Vascular Endothelial Cells: Relationship to Cancer Metastasis and Atherogenesis
    Toxicological Sciences, vol. 75, no. 1, pp. 47–56, 2003
  26. HIV-Tat protein induces oxidative and inflammatory pathways in brain endothelium
    Journal of Neurochemistry, vol. 84, no. 1, pp. 169–179, 2003
  27. HIV-1 tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain
    Molecular and Cellular Neuroscience, vol. 24, no. 1, pp. 224–237, 2003
  28. 2,2',4,6,6'-pentachlorobiphenyl (PCB 104) induces apoptosis of human microvascular endothelial cells through the caspase-dependent activation of CREB
    Toxicology and Applied Pharmacology, vol. 189, no. 1, pp. 1–10, 2003
  29. HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells
    Journal of Neuroscience Research, vol. 74, no. 2, pp. 255–265, 2003
  30. Methamphetamine Potentiates HIV-1 Tat Protein-Mediated Activation of Redox-Sensitive Pathways in Discrete Regions of the Brain
    Experimental Neurology, vol. 179, no. 1, pp. 60–70, 2003