Kuniyasu Soda received the M.D. and Ph.D. degrees. Soda is an Associate Professor at Graduate School, Doctor Course of Medical Science, Jichi Medical University. Soda’s areas of expertise include polyamine, lifespan extension, healthy food, and immune function. Soda’s research program is focused on the study of food polyamines (spermine and spermidine) on human health and diseases. Soda and his colleagues have shown that healthy foods and dietary pattern, such as Mediterranean diet and Japanese food, are rich in polyamine. And, Soda’s group has shown that long term and continuous increased polyamine intake elevates body polyamine levels in humans and mice and that the increased polyamine intake inhibits the progression of age-associated pathologies and prolong longevity of mice (Exp. Gerontology 44: 727-732, 2009.). These experiments were planned based on the research results in which polyamines suppress proinflammatory status (J. Immunol. 175: 237-245, 2005.). Aging is associated with increased proinflammatory status, and chronic mild inflammation is considered one of the major causes of many age-associated diseases and aging. Soda’s laboratory is investigating the mechanism by which polyamines suppress proinflammatory status and extend lifespan. And, more recently, we have found that increased polyamine supply enhances the activities of DNA methyltransferase and suppressed age-associated or polyamine-deficient induced abnormal gene methylation status (increased global demethylation and methylation) (PLoS ONE 8(2): e56056, 2013., PLoS ONE 8(5): e64357. 2013).
Biography Updated on 22 December 2013