Paola Costanzo was born in Naples, Italy, in 1958. She received her degree in biological science (summa cum laude) at the University of Naples Federico II, Naples, Italy, in 1980. After serving as Laboratory Researcher of CNR at the Faculty of Medicine, University of Naples Federico II, from 1982 to 2000, she joined the Faculty of Medicine, Magna Græcia University of Catanzaro, as Associate Professor of biochemistry. Since 2004, she is an Associate Professor of biochemistry at the Faculty of Biotechnology, University of Naples Federico II. Initially, the research activity of Costanzo has been focused on the isolation, structural characterization, and transcriptional regulation of glycolytic enzyme genes in eukaryotes. Her current research focuses on the role of zinc finger proteins as transcriptional regulators. In particular, a new Kruppel-like transcriptional repressor, named ZNF224, was isolated and characterized in her laboratory. Different proteins that interact with ZNF224 and take part in the transcriptional repression complex have been identified, these include the arginine methyl-transferase PRMT5 and the Wilms' tumour protein, WT1.
Biography Updated on 7 September 2011