Peter Schuck
Peter Schuck received his Ph.D. degree in biophysics from the Johann-Wolfgang Goethe-Unversity Frankfurt, Germany, in 1994. For his dissertation, he was characterizing the oligomeric state and heterogeneous interactions of the detergent-solubilized band 3 protein from the erythrocyte membrane, and developing multi-wavelength analytical ultracentrifugation techniques. From 1994 to 1997, he was a Visiting Fellow in the laboratory of Dr. Allen Minton in the Laboratory of Biochemistry and Genetics, NIDDK, at the National Institutes of Health in Bethesda, where he worked on problems in optical biosensing and sedimentation velocity as tools for the study of protein interactions. From 1997 to 2003, he was a Visiting Associate and Staff Scientist in the Division of Bioengineering and Physical Science, OD, at the National Institutes of Health, developing and applying various biophysical methods for the study of macromolecular interactions. Since 2003, he is Chief of the Protein Biophysics Section, now located in LBPS at the National Institute of Biomedical Imaging and Bioengineering. Dr. Schuck is an Editorial Board member of The Protein Journal, Faculty Member in the Experimental Biophysical Methods section of the Structural Biology faculty of F1000 Biology, and editor of the book Protein Interactions - Biophysical Approaches for the Study of Complex Reversible Systems (Protein Reviews Vol. 5). He is organizer of the semiannual workshop on “Hydrodynamic and Thermodynamic Analysis of Macromolecules with sedfit and sedphat”, and author of a several widely used public domain computational biophysical analysis programs.
Biography Updated on 12 January 2008
Personal Home Page
http://www.nibib.nih.gov/Research/Intramural/LBPS/Staff/Schuck
Articles in Scholarly Journals [Incomplete List]
- A new adaptive grid-size algorithm for the simulation of sedimentation velocity profiles in analytical ultracentrifugation
Computer Physics Communications, vol. 178, no. 2, pp. 105–120, 2008 - Single-walled tubulin ring polymers
Biopolymers, vol. 86, no. 5-6, pp. 424–436, 2007 - Superantigen natural affinity maturation revealed by the crystal structure of staphylococcal enterotoxin G and its binding to T-cell receptor Vß8.2
Proteins: Structure, Function, and Bioinformatics, vol. 68, no. 1, pp. 389–402, 2007 - Two Interferons Alpha Influence Each Other during Their Interaction with the Extracellular Domain of Human Type Interferon Receptor Subunit 2
Biochemistry, vol. 46, no. 50, pp. 14638–14649, 2007 - Using Prior Knowledge in the Determination of Macromolecular Size-Distributions by Analytical Ultracentrifugation
Biomacromolecules, vol. 8, no. 6, pp. 2011–2024, 2007 - Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1
Nature Structural & Molecular Biology, vol. 13, no. 9, Article ID nsmb1133, 7 pages, 2006 - Chimpanzee/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus
Proceedings of the National Academy of Sciences, vol. 103, no. 6, pp. 1882–1887, 2006 - Quaternary Structure and Cleavage Specificity of a Poxvirus Holliday Junction Resolvase
Journal of Biological Chemistry, vol. 281, no. 17, pp. 11618–11626, 2006 - Efficient Neutralization of Anthrax Toxin by Chimpanzee Monoclonal Antibodies against Protective Antigen
The Journal of Infectious Diseases, vol. 193, no. 5, pp. 625–633, 2006 - Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: Application to adaptor protein complexes in cell signaling
Protein Science, vol. 16, no. 1, pp. 30–42, 2006 - Protein S multimers and monomers each have direct anticoagulant activity
Journal of Thrombosis and Haemostasis, vol. 4, no. 2, pp. 385–391, 2006 - Macromolecular Size-and-Shape Distributions by Sedimentation Velocity Analytical Ultracentrifugation
Biophysical Journal, vol. 90, no. 12, pp. 4651–4661, 2006 - Probing the Functional Heterogeneity of Surface Binding Sites by Analysis of Experimental Binding Traces and the Effect of Mass Transport Limitation
Biophysical Journal, vol. 92, no. 5, pp. 1742–1758, 2006 - Variable Dimerization of the Ly49A Natural Killer Cell Receptor Results in Differential Engagement of its MHC Class I Ligand
Journal of Molecular Biology, vol. 362, no. 1, pp. 102–113, 2006 - Crystal Structure of Group A Streptococcus Mac-1: Insight into Dimer-Mediated Specificity for Recognition of Human IgG
Structure, vol. 14, no. 2, pp. 225–235, 2006 - Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapy
Virology, vol. 332, no. 2, pp. 491–497, 2005 - Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains
Cellular Signalling, vol. 17, no. 10, pp. 1276–1288, 2005 - Biochemistry, vol. 44, no. 23, pp. 8470–8478, 2005
- Biochemistry, vol. 44, no. 39, pp. 13122–13131, 2005
- Sedimentation Velocity Analysis of Heterogeneous Protein-Protein Interactions: Lamm Equation Modeling and Sedimentation Coefficient Distributions c(s)
Biophysical Journal, vol. 89, no. 1, pp. 619–634, 2005 - Sedimentation Velocity Analysis of Heterogeneous Protein-Protein Interactions: Sedimentation Coefficient Distributions c(s) and Asymptotic Boundary Profiles from Gilbert-Jenkins Theory
Biophysical Journal, vol. 89, no. 1, pp. 651–666, 2005 - Characterization of DC-SIGN/R Interaction with Human Immunodeficiency Virus Type 1 gp120 and ICAM Molecules Favors the Receptor's Role as an Antigen-Capturing Rather than an Adhesion Receptor
Journal of Virology, vol. 79, no. 8, pp. 4589–4598, 2005 - A Mechanism for Assembly of Complexes of Vitronectin and Plasminogen Activator Inhibitor-1 from Sedimentation Velocity Analysis
Journal of Biological Chemistry, vol. 280, no. 31, pp. 28711–28720, 2005 - Dissection of Merozoite Surface Protein 3, a Representative of a Family of Plasmodium falciparum Surface Proteins, Reveals an Oligomeric and Highly Elongated Molecule
Journal of Biological Chemistry, vol. 280, no. 44, pp. 37236–37245, 2005 - Studying multiprotein complexes by multisignal sedimentation velocity analytical ultracentrifugation
Proceedings of the National Academy of Sciences, vol. 102, no. 1, pp. 81–86, 2005 - Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin X 2
Proceedings of the National Academy of Sciences, vol. 102, no. 5, pp. 1614–1619, 2005 - Cooperative behavior of Escherichia coli cell-division protein FtsZ assembly involves the preferential cyclization of long single-stranded fibrils
Proceedings of the National Academy of Sciences, vol. 102, no. 6, pp. 1895–1900, 2005 - Biochemistry, vol. 43, no. 14, pp. 4170–4178, 2004
- Hydrodynamics of Nanoscopic Tubulin Rings in Dilute Solutions
Physical Review Letters, vol. 93, no. 9, 2004 - Crystal Structure of the C-terminal Peptidoglycan-binding Domain of Human Peptidoglycan Recognition Protein I
Journal of Biological Chemistry, vol. 279, no. 30, pp. 31873–31882, 2004 - SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity
Molecular Immunology, vol. 41, no. 9, pp. 863–872, 2004 - Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition
Analytical Biochemistry, vol. 326, no. 2, pp. 234–256, 2004 - A model for sedimentation in inhomogeneous media. I. Dynamic density gradients from sedimenting co-solutes
Biophysical Chemistry, vol. 108, no. 1-3, pp. 187–200, 2004 - A model for sedimentation in inhomogeneous media. II. Compressibility of aqueous and organic solvents
Biophysical Chemistry, vol. 108, no. 1-3, pp. 201–214, 2004 - Minimizing immunogenicity of the SDR-grafted humanized antibody CC49 by genetic manipulation of the framework residues
Molecular Immunology, vol. 40, no. 6, pp. 337–349, 2003 - On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation
Analytical Biochemistry, vol. 320, no. 1, pp. 104–124, 2003 - Inhibition of Hemostasis by a High Affinity Biogenic Amine-binding Protein from the Saliva of a Blood-feeding Insect
Journal of Biological Chemistry, vol. 278, no. 7, pp. 4611–4617, 2003 - Alanine-scanning Mutations in Domain 4 of Anthrax Toxin Protective Antigen Reveal Residues Important for Binding to the Cellular Receptor and to a Neutralizing Monoclonal Antibody
Journal of Biological Chemistry, vol. 278, no. 33, pp. 30936–30944, 2003 - Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb
Nature Immunology, vol. 4, no. 12, Article ID ni1006, 9 pages, 2003 - Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions
European Journal of Biochemistry, vol. 269, no. 23, pp. 5939–5949, 2002 - Biochemical and Biological Characterization of a Dodecameric CD4-Ig Fusion Protein. IMPLICATIONS FOR THERAPEUTIC AND VACCINE STRATEGIES
Journal of Biological Chemistry, vol. 277, no. 13, pp. 11456–11464, 2002 - Analysis of a Temperature-Sensitive Mutant Rotavirus Indicates that NSP2 Octamers Are the Functional Form of the Protein
Journal of Virology, vol. 76, no. 14, pp. 7082–7093, 2002 - Modern analytical ultracentrifugation in protein science: A tutorial review
Protein Science, vol. 11, no. 9, pp. 2067–2079, 2002 - Surface plasmon resonance-based competition assay to assess the sera reactivity of variants of humanized antibodies
Journal of Immunological Methods, vol. 268, no. 2, pp. 197–210, 2002 - Biochemistry, vol. 41, no. 16, pp. 5177–5184, 2002
- Analytical Chemistry, vol. 74, no. 9, pp. 2041–2047, 2002
- Crystal Structure of a Superantigen Bound to the High-Affinity, Zinc-Dependent Site on MHC Class II
Immunity, vol. 14, no. 1, pp. 93–104, 2001 - Analytical Chemistry, vol. 73, no. 13, pp. 2828–2835, 2001
- Rotavirus Nonstructural Protein NSP2 Self-assembles into Octamers That Undergo Ligand-induced Conformational Changes
Journal of Biological Chemistry, vol. 276, no. 13, pp. 9679–9687, 2001 - Oligomeric structure of virion-associated and soluble forms of the simian immunodeficiency virus envelope protein in the prefusion activated conformation
Proceedings of the National Academy of Sciences, vol. 98, no. 26, pp. 14877–14882, 2001 - Self-association of Human Apolipoprotein E3 and E4 in the Presence and Absence of Phospholipid
Journal of Biological Chemistry, vol. 275, no. 47, pp. 36758–36765, 2000 - The Human Immunodeficiency Virus Type 1 gp120 V2 Domain Mediates gp41-Independent Intersubunit Contacts
Journal of Virology, vol. 74, no. 10, pp. 4448–4455, 2000 - Biochemistry, vol. 39, no. 24, pp. 7291–7299, 2000
- Determination of the sedimentation coefficient distribution by least-squares boundary modeling
Biopolymers, vol. 54, no. 5, pp. 328–341, 2000 - Analysis of Transport Experiments Using Pseudo-Absorbance Data
Analytical Biochemistry, vol. 285, no. 1, pp. 135–142, 2000 - An antibody single-domain phage display library of a native heavy chain variable region: isolation of functional single-domain VH molecules with a unique interface
Journal of Molecular Biology, vol. 290, no. 3, pp. 685–698, 1999 - Sedimentation Equilibrium Analysis of Interference Optical Data by Systematic Noise Decomposition
Analytical Biochemistry, vol. 272, no. 2, pp. 199–208, 1999 - Characterizing the Solution Properties of Supramolecular Systems by Analytical Ultracentrifugation
Chemistry - A European Journal, vol. 5, no. 5, pp. 1377–1383, 1999 - Sedimentation equilibrium analysis of recombinant mouse FcRn with murine IgG1
Molecular Immunology, vol. 36, no. 15-16, pp. 1117–1125, 1999 - Salt Links Dominate Affinity of Antibody HyHEL-5 for Lysozyme through Enthalpic Contributions
Journal of Biological Chemistry, vol. 274, no. 38, pp. 26838–26842, 1999 - Biochemistry, vol. 37, no. 46, pp. 16152–16164, 1998
- Determination of Binding Constants by Equilibrium Titration with Circulating Sample in a Surface Plasmon Resonance Biosensor
Analytical Biochemistry, vol. 265, no. 1, pp. 79–91, 1998 - Reliable determination of binding affinity and kinetics using surface plasmon resonance biosensors
Current Opinion in Biotechnology, vol. 8, no. 4, pp. 498–502, 1997 - USE OF SURFACE PLASMON RESONANCE TO PROBE THE EQUILIBRIUM AND DYNAMIC ASPECTS OF INTERACTIONS BETWEEN BIOLOGICAL MACROMOLECULES1
Annual Review of Biophysics and Biomolecular Structure, vol. 26, no. 1, pp. 541–566, 1997 - Kinetic analysis of biosensor data: elementary tests for self-consistency
Trends in Biochemical Sciences, vol. 21, no. 12, pp. 458–460, 1996 - Analysis of Mass Transport-Limited Binding Kinetics in Evanescent Wave Biosensors
Analytical Biochemistry, vol. 240, no. 2, pp. 262–272, 1996