Mark Chance received his B.S. degree in biology from Wesleyan University and his Ph.D. degree in biophysics from the University of Pennsylvania. Dr. Chance furthered his training as a Postdoctoral Research Associate at AT&T Bell Laboratories. He went on to become an Assistant Professor at the Department of Chemistry at Georgetown University. He then served as an Assistant Professor at Albert Einstein College of Medicine in Bronx, New York and was soon promoted to an Associate Professor at the Departments of Physiology & Biophysics and Biochemistry. He was Professor at AECOM when he moved to the Case Western Reserve University School of Medicine in 2005, where he is currently the Director of both the Case Center for Proteomics and Bioinformatics and Case Center for Synchrotron Biosciences and the Professor of physiology and biophysics. Chance's lab uses quantitative mass spectrometry and 2D gel techniques in order to identify biomarkers and regulatory pathways in complex diseases such as colon cancer, diabetes, radiation exposure, and HIV infection. A major emphasis is placed on applying state-of-the-art proteomics and systems biology tools to investigate HIV pathogenesis in the context of drug abuse and provide significant biomarkers of HIV infection, coinfection with other viruses, and drug abuse. The use of high-resolution mass spectrometry instruments of the Center, coupled to the advanced bioinformatics and biostatistical pipelines for analysis, provides quantitative label free protein expression analysis using a “shotgun” proteomics approach. Subsequent analysis using network and pathway tools provides novel insights into pathophysiological changes in this disease as well as the underlying immunobiology of progression.
Biography Updated on 22 November 2009