Anita H. Corbett

Anita H. Corbett obtained the undergraduate degree in chemistry/biochemistry from Colgate University in New York where the undergraduate research focused primarily on enzyme kinetics. She then moved to Vanderbilt University in Nashville, Tenn, to attend graduate school in biochemistry. She worked with Dr. Neil Osheroff on the mechanism of action of topoisomerase II and completed the Ph.D. degree in 1992. She then moved to Dana Farber Cancer Institute/Harvard Medical School for postdoctoral work. This work was done in Dr. Pam Silver's lab where she was introduced to the budding yeast Saccharomyces cerevisiae as a model system, which she used to study macromolecular movement into and out of the cell nucleus. In 1997, she accepted a faculty position in the Department of Biochemistry at Emory University in Atlanta, Ga. Her research is focused on understanding the molecular mechanisms underlying nuclear protein import and mRNA processing and export. They use a variety of techniques ranging from yeast genetic to biophysics and structural biology. She is currently an Associate Professor of Biochemistry and also serves as Director of the Biochemistry, Cell, and Developmental Biology Graduate Program.

Biography Updated on 8 November 2007

Personal Home Page

http://www.biochem.emory.edu/labs/acorbe2/index.html

Articles in Scholarly Journals [Incomplete List]

  1. Recognition of polyadenosine RNA by zinc finger proteins
    Proceedings of the National Academy of Sciences, vol. 104, no. 30, pp. 12306–12311, 2007
  2. Functional overlap between conserved and diverged KH domains in Saccharomyces cerevisiae SCP160
    Nucleic Acids Research, vol. 35, no. 4, pp. 1108–1118, 2007
  3. Enteropathogenic Escherichia coli Tir is an SH2/3 ligand that recruits and activates tyrosine kinases required for pedestal formation
    Molecular Microbiology, vol. 63, no. 6, pp. 1748–1768, 2007
  4. An Interaction between Two RNA Binding Proteins, Nab2 and Pub1, Links mRNA Processing/Export and mRNA Stability
    Molecular and Cellular Biology, vol. 27, no. 18, pp. 6569–6579, 2007
  5. Identification and Characterization of the Arabidopsis Orthologs of Nuclear Transport Factor 2, the Nuclear Import Factor of Ran
    PLANT PHYSIOLOGY, vol. 140, no. 3, pp. 869–878, 2006
  6. Nuclear Localization Signal Receptor Affinity Correlates with in Vivo Localization in Saccharomyces cerevisiae
    Journal of Biological Chemistry, vol. 281, no. 33, pp. 23545–23556, 2006
  7. Actively Transcribed GAL Genes Can Be Physically Linked to the Nuclear Pore by the SAGA Chromatin Modifying Complex
    Journal of Biological Chemistry, vol. 282, no. 5, pp. 3042–3049, 2006
  8. Classical Nuclear Localization Signals: Definition, Function, and Interaction with Importin  
    Journal of Biological Chemistry, vol. 282, no. 8, pp. 5101–5105, 2006
  9. A Yeast Model System for Functional Analysis of the Niemann-Pick Type C Protein 1 Homolog, Ncr1p
    Traffic, vol. 6, no. 10, pp. 907–917, 2005
  10. Saccharomyces cerevisiae Npc2p Is a Functionally Conserved Homologue of the Human Niemann-Pick Disease Type C 2 Protein, hNPC2
    Eukaryotic Cell, vol. 4, no. 11, pp. 1851–1862, 2005
  11. Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II
    Nucleic Acids Research, vol. 33, no. 3, pp. 1021–1030, 2005
  12. Process or perish: quality control in mRNA biogenesis
    Nature Structural & Molecular Biology, vol. 12, no. 6, Article ID nsmb945, 6 pages, 2005
  13. Hot trends erupting in the nuclear transport field
    EMBO reports, vol. 5, no. 5, Article ID 7400155, 5 pages, 2004
  14. Importin ?: a multipurpose nuclear-transport receptor
    Trends in Cell Biology, vol. 14, no. 9, pp. 505–514, 2004
  15. Both KH and non-KH domain sequences are required for polyribosome association of Scp160p in yeast
    Nucleic Acids Research, vol. 32, no. 16, pp. 4768–4775, 2004
  16. Regulation of Nuclear Import by Phosphorylation Adjacent to Nuclear Localization Signals
    Journal of Biological Chemistry, vol. 279, no. 20, pp. 20613–20621, 2004
  17. Structural basis for Nup2p function in cargo release and karyopherin recycling in nuclear import
    The EMBO Journal, vol. 22, no. 20, pp. 5358–5369, 2003
  18. The C-terminal domain of myosin-like protein 1 (Mlp1p) is a docking site for heterogeneous nuclear ribonucleoproteins that are required for mRNA export
    Proceedings of the National Academy of Sciences, vol. 100, no. 3, pp. 1010–1015, 2003
  19. Domain Analysis of the Saccharomyces cerevisiae Heterogeneous Nuclear Ribonucleoprotein, Nab2p. DISSECTING THE REQUIREMENTS FOR Nab2p-FACILITATED POLY(A) RNA EXPORT
    Journal of Biological Chemistry, vol. 278, no. 9, pp. 6731–6740, 2003
  20. The Auto-inhibitory Function of Importin alpha Is Essential in Vivo
    Journal of Biological Chemistry, vol. 278, no. 8, pp. 5854–5863, 2003
  21. Characterization of the Auto-inhibitory Sequence within the N-terminal Domain of Importin  
    Journal of Biological Chemistry, vol. 278, no. 24, pp. 21361–21369, 2003
  22. Dissection of the Karyopherin   Nuclear Localization Signal (NLS)-binding Groove: FUNCTIONAL REQUIREMENTS FOR NLS BINDING
    Journal of Biological Chemistry, vol. 278, no. 43, pp. 41947–41953, 2003
  23. Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats
    The EMBO Journal, vol. 21, no. 12, pp. 2843–2853, 2002
  24. Importin alpha can migrate into the nucleus in an importin beta- and Ran-independent manner
    The EMBO Journal, vol. 21, no. 21, pp. 5833–5842, 2002
  25. Nab2p Is Required for Poly(A) RNA Export in Saccharomyces cerevisiae and Is Regulated by Arginine Methylation via Hmt1p
    Journal of Biological Chemistry, vol. 277, no. 10, pp. 7752–7760, 2002
  26. Nuclear RanGTP is not required for targeting small nucleolar RNAs to the nucleolus
    Journal of Cell Science, vol. 116, no. 1, pp. 177–186, 2002
  27. Identification and characterization of the human MOG1 gene
    Gene, vol. 266, no. 1-2, pp. 45–56, 2001
  28. Nuclear transport mechanisms
    Cellular and Molecular Life Sciences, vol. 58, no. 12, pp. 1766–1773, 2001
  29. Functional analysis of the yeast Ran exchange factor Prp20p: in vivo evidence for the RanGTP gradient model
    Molecular Genetics and Genomics, vol. 265, no. 5, pp. 851–864, 2001
  30. Dissection of a Nuclear Localization Signal
    Journal of Biological Chemistry, vol. 276, no. 2, pp. 1317–1325, 2001
  31. Functional Analysis of the Hydrophobic Patch on Nuclear Transport Factor 2 Involved in Interactions with the Nuclear Pore in Vivo
    Journal of Biological Chemistry, vol. 276, no. 42, pp. 38820–38829, 2001
  32. Interaction between Ran and Mog1 Is Required for Efficient Nuclear Protein Import
    Journal of Biological Chemistry, vol. 276, no. 44, pp. 41255–41262, 2001
  33. Carboxymethylation of the PP2A Catalytic Subunit in Saccharomyces cerevisiae Is Required for Efficient Interaction with the B-type Subunits Cdc55p and Rts1p
    Journal of Biological Chemistry, vol. 276, no. 2, pp. 1570–1577, 2000
  34. SAC3 may link nuclear protein export to cell cycle progression
    Proceedings of the National Academy of Sciences, vol. 97, no. 7, pp. 3224–3229, 2000
  35. Quantitative Analysis of Nuclear Localization Signal (NLS)-Importin alpha Interaction through Fluorescence Depolarization. EVIDENCE FOR AUTO-INHIBITORY REGULATION OF NLS BINDING
    Journal of Biological Chemistry, vol. 275, no. 28, pp. 21218–21223, 2000
  36. The Mechanism of Ran Import into the Nucleus by Nuclear Transport Factor 2
    Journal of Biological Chemistry, vol. 275, no. 37, pp. 28575–28582, 2000
  37. SGD1 encodes an essential nuclear protein of Saccharomyces cerevisiae that affects expression of the GPD1 gene for glycerol 3-phosphate dehydrogenase
    FEBS Letters, vol. 483, no. 2-3, pp. 87–92, 2000
  38. Crystallization and Initial X-Ray Diffraction Characterization of Complexes of FxFG Nucleoporin Repeats with Nuclear Transport Factors
    Journal of Structural Biology, vol. 131, no. 3, pp. 240–247, 2000
  39. The Molecular Mechanism of Transport of Macromolecules Through Nuclear Pore Complexes
    Traffic, vol. 1, no. 6, pp. 448–456, 2000
  40. Engineered mutants in the switch II loop of ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import
    Journal of Molecular Biology, vol. 289, no. 3, pp. 565–577, 1999
  41. Biochemistry, vol. 38, no. 35, pp. 11298–11306, 1999
  42. Nuclear moguls meet
    Trends in Cell Biology, vol. 7, no. 6, pp. 252–253, 1997
  43. Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran
    Journal of Molecular Biology, vol. 272, no. 5, pp. 716–730, 1997
  44. Genetic Analysis of Macromolecular Transport across the Nuclear Envelope
    Experimental Cell Research, vol. 229, no. 2, pp. 212–216, 1996
  45. The NTF2 Gene Encodes an Essential, Highly Conserved Protein That Functions in Nuclear Transport in Vivo
    Journal of Biological Chemistry, vol. 271, no. 31, pp. 18477–18484, 1996
  46. Dynamic localization of the nuclear import receptor and its interactions with transport factors
    The Journal of Cell Biology, vol. 133, no. 6, pp. 1163–1176, 1996
  47. Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import
    The Journal of Cell Biology, vol. 130, no. 5, pp. 1017–1026, 1995
  48. Abasic Sites Stimulate Double-stranded DNA Cleavage Mediated by Topoisomerase II
    Journal of Biological Chemistry, vol. 270, no. 37, pp. 21441–21444, 1995
  49. Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes
    Cancer Chemotherapy and Pharmacology, vol. 34, no. S1, pp. S19–S25, 1994
  50. Biochemistry, vol. 32, no. 8, pp. 2090–2097, 1993
  51. Biochemistry, vol. 32, no. 14, pp. 3638–3643, 1993
  52. Chemical Research in Toxicology, vol. 6, no. 5, pp. 585–597, 1993