Dennis Daniel Taub

Dennis Daniel Taub was born on September 27, 1964 in Norfolk, Va, USA. In 1985, he received his B.S. degree in microbiology and the B.S. degree in medical technology from Pennsylvania State University, University Park, Pa, USA (summa cum laude). In 1991, he obtained the Ph.D. degree in microbiology and immunology from Temple University School of Medicine, Philadelphia, Pa, USA. From 1983 to 1988, Taub worked as a Medical Technologist and a Night-Call Supervisor, full time and part time, at Pennsylvania Hospital, Medical College of Pennsylvania and Graduate Hospital, Philadelphia, Pa, USA (multiple disciplines including Blood Bank, Microbiology, STAT Lab, Hematology, Serology, Chemistry). During 1988–1991, he was a graduate student at Temple University of Medicine, Philadelphia, Pa, USA. His thesis is entitled "The immunoregulatory effects of staphylococcal enterotoxin B", under the supervision of Dr. Thomas J. Rogers. Taub became a Research Associate (Dr. Ken Blank) at the Department of Pathology and Lab Medicine, Hahnemann University School of Medicine, Philadelphia, Pa, USA. Between 1991 and 1993, he served as a Staff Fellow at the Laboratory of Molecular Immunoregulation, National Cancer Institute, NIH, Frederick, Md, USA. He was the Head of the Clinical Monitoring/Vaccine Research Laboratory, National Cancer Institute-Frederick Cancer Research and Development, SAIC-Frederick, Md, USA (1993–1997). Since 1997, he was the Acting Chief at the Laboratory of Immunology Chief, Clinical Immunology Section, GRC, NIA, NIH, Baltimore, Md, USA. From 1998 to 2004, he worked as a Director and Manager at the Clinical Core Laboratory, GRC, NIA, NIH, Baltimore, Md, USA [CLIA-licensed laboratory in over 49 tests]. He served as a Safety Chairperson, GRC, NIA, NIH, Baltimore, Md, USA, from 1997 to 2002 . Moreover, he served as the Chief of the Central Laboratory Services Section, RRB, GRC, NIA, NIH, Baltimore, Md, USA, between 1999 and 2002. Since 2006, Taub was the Director of Clinical Core Laboratory, CRB, GRC, NIA, NIH, Baltimore, Md, USA [CLIA-licensed for certain testing]. Recently, he is the Head of NIA-IRP repository, NIA, NIH, Baltimore, Md, USA.

Biography Updated on 5 August 2008

Articles in Scholarly Journals [Incomplete List]

  1. Effects of knee injection on skeletal muscle metabolism and contractile force in rats
    Osteoarthritis and Cartilage, vol. 15, no. 5, pp. 550–558, 2007
  2. Transcriptome analysis of age-, gender- and diet-associated changes in murine thymus?
    Cellular Immunology, vol. 245, no. 1, pp. 42–61, 2007
  3. Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues
    Experimental Cell Research, vol. 313, no. 3, pp. 450–461, 2007
  4. qPrimerDepot: a primer database for quantitative real time PCR
    Nucleic Acids Research, vol. 35, no. Database, pp. D805–D809, 2007
  5. Ghrelin and the Growth Hormone Secretagogue Receptor Constitute a Novel Autocrine Pathway in Astrocytoma Motility
    Journal of Biological Chemistry, vol. 281, no. 24, pp. 16681–16690, 2006
  6. Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility
    Oncogene, vol. 26, no. 26, Article ID 1210155, 10 pages, 2006
  7. Transient Improvement in Cognitive Function and Synaptic Plasticity in Rats Following Cancer Chemotherapy
    Clinical Cancer Research, vol. 12, no. 1, pp. 198–205, 2006
  8. BMC Immunology, vol. 7, no. 1, p. 27, 2006
  9. Serum Erythropoietin and Aging: A Longitudinal Analysis
    Journal of the American Geriatrics Society, vol. 53, no. 8, pp. 1360–1365, 2005
  10. Pharmacologic profiling of transcriptional targets deciphers promoter logic
    The Pharmacogenomics Journal, vol. 5, no. 5, Article ID 6500325, 18 pages, 2005
  11. Insights into thymic aging and regeneration
    Immunological Reviews, vol. 205, no. 1, pp. 72–93, 2005
  12. Ghrelin and immunity: A young player in an old field
    Experimental Gerontology, vol. 40, no. 11, pp. 900–910, 2005
  13. Dynamic reorganization of chemokine receptors, cholesterol, lipid rafts, and adhesion molecules to sites of CD4 engagement
    Experimental Cell Research, vol. 304, no. 2, pp. 559–569, 2005
  14. Relation of Plasma Leptin to C-Reactive Protein in Older Adults (from the Invecchiare nel Chianti Study)
    The American Journal of Cardiology, vol. 96, no. 7, pp. 991–995, 2005
  15. Alterations in mast cell function and survival following in vitro infection with human immunodeficiency viruses-1 through CXCR4
    Cellular Immunology, vol. 230, no. 2, pp. 65–80, 2004
  16. The immunoregulatory effects of homocysteine and its intermediates on T-lymphocyte function
    Mechanisms of Ageing and Development, vol. 125, no. 2, pp. 107–110, 2004
  17. Cellular cholesterol enrichment impairs T cell activation and chemotaxis
    Mechanisms of Ageing and Development, vol. 125, no. 9, pp. 641–650, 2004
  18. Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration
    Experimental Cell Research, vol. 297, no. 1, pp. 197–211, 2004
  19. PTEN permits acute increases in D3-phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt
    European Journal of Immunology, vol. 34, no. 11, pp. 3165–3175, 2004
  20. Regulation of Mast Cell Migration by TH1 and TH2 Cytokines: Identification of Tumour Necrosis Factor-alpha and Interleukin-4 as Mast Cell Chemotaxins
    Scandinavian Journal of Immunology, vol. 59, no. 3, pp. 267–272, 2004
  21. Gene Expression Profiling: From Microarrays to Medicine
    Journal of Clinical Immunology, vol. 24, no. 3, pp. 213–224, 2004
  22. Ancient viral protein enrages astrocytes in multiple sclerosis
    Nature Neuroscience, vol. 7, no. 10, Article ID nn1004-1021, 2 pages, 2004
  23. Targeting Lipids to Prevent HIV Infection
    Molecular Interventions, vol. 4, no. 6, pp. 318–320, 2004
  24. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells
    Journal of Clinical Investigation, vol. 114, no. 1, pp. 57–66, 2004
  25. BMC Immunology, vol. 5, no. 1, p. 15, 2004
  26. BMC Immunology, vol. 5, no. 1, p. 17, 2004
  27. BMC Immunology, vol. 5, no. 1, p. 2, 2004
  28. Postoperative Fever After Total Knee Arthroplasty: The Role of Cytokines
    Clinical Orthopaedics and Related Research, vol. 415, pp. 221–231, 2003
  29. Blockade of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Exacerbates Type 1 Diabetes in NOD Mice
    Diabetes, vol. 52, no. 8, pp. 1967–1975, 2003
  30. MIP-1alpha and MIP-1beta differentially mediate mucosal and systemic adaptive immunity
    Blood, vol. 101, no. 3, pp. 807–814, 2003
  31. Gonadotropin-Releasing Hormone Attenuates Pregnancy-Associated Thymic Involution and Modulates the Expression of Antiproliferative Gene Product Prohibitin
    Endocrinology, vol. 144, no. 4, pp. 1496–1505, 2003
  32. Leptin Induces Growth Hormone Secretion from Peripheral Blood Mononuclear Cells via a Protein Kinase C- and Nitric Oxide-Dependent Mechanism
    Endocrinology, vol. 144, no. 12, pp. 5595–5603, 2003
  33. Transcriptome Analysis of Mouse Stem Cells and Early Embryos
    PLoS Biology, vol. 1, no. 3, p. e4, 2003
  34. Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of l-serine biosynthesis
    Biochemical Journal, vol. 373, no. 1, p. 191, 2003
  35. Membrane incorporation of 22-hydroxycholesterol inhibits chemokine receptor activity
    Experimental Cell Research, vol. 285, no. 2, pp. 268–277, 2003
  36. Inhibition of chemokine receptor function by membrane cholesterol oxidation
    Experimental Cell Research, vol. 291, no. 1, pp. 36–45, 2003
  37. Age-Related Immune Dysfunction in Health and in Human Immunodeficiency Virus (HIV) Disease: Association of Age and HIV Infection with Naive CD8+ Cell Depletion, Reduced Expression of CD28 on CD8+ Cells, and Reduced Thymic Volumes
    The Journal of Infectious Diseases, vol. 187, no. 12, pp. 1924–1933, 2003
  38. Differential Transcriptional Regulation by Human Immunodeficiency Virus Type 1 and gp120 in Human Astrocytes
    Journal of Neurovirology, vol. 9, no. 3, pp. 358–371, 2003
  39. Mechanism underlying cytotoxicity of thialysine, lysine analog, toward human acute leukemia Jurkat T cells
    Biochemical Pharmacology, vol. 66, no. 12, pp. 2291–2300, 2003
  40. Cytokine Responses in Young and Old Rhesus Monkeys: Effect of Caloric Restriction
    Journal of Interferon Cytokine Research, vol. 22, no. 5, pp. 565–571, 2002
  41. Activation-induced cell death of aggressive histology lymphomas by CD40 stimulation: induction of bax
    Blood, vol. 100, no. 1, pp. 217–223, 2002
  42. Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis
    Blood, vol. 100, no. 13, pp. 4291–4297, 2002
  43. Effect of rapamycin on the cyclosporin A-resistant CD28-mediated costimulatory pathway
    Blood, vol. 99, no. 12, pp. 4517–4524, 2002
  44. Cholesterol is essential for macrophage inflammatory protein 1beta binding and conformational integrity of CC chemokine receptor 5
    Blood, vol. 99, no. 12, pp. 4298–4306, 2002
  45. Gene Expression Profile of Herpesvirus-Infected T Cells Obtained Using Immunomicroarrays: Induction of Proinflammatory Mechanisms
    Journal of Virology, vol. 75, no. 23, pp. 11641–11650, 2001
  46. Human Recombinant Interferon-Inducible Protein-10: Intact Disulfide Bridges Are Not Required for Inhibition of Hematopoietic Progenitors and Chemotaxis of T Lymphocytes and Monocytes
    Journal of Hematotherapy Stem Cell Research, vol. 10, no. 1, pp. 147–156, 2001
  47. EARLY INCREASED CHEMOKINE EXPRESSION AND PRODUCTION IN MURINE ALLOGENEIC SKIN GRAFTS IS MEDIATED BY NATURAL KILLER CELLS1
    Transplantation, pp. 969–977, 2000
  48. Identification and Characterization of a Potent, Selective, and Orally Active Antagonist of the CC Chemokine Receptor-1
    Journal of Biological Chemistry, vol. 275, no. 25, pp. 19000–19008, 2000
  49. Role for CD40–CD40 ligand interactions in the immune response to solid tumours
    Molecular Immunology, vol. 37, no. 9, pp. 515–526, 2000
  50. Demonstration that platelet-activating factor is capable of activating mast cells and inducing a chemotactic response
    Immunology, vol. 99, no. 2, pp. 314–319, 2000
  51. Assignment1 of human 3-phosphoglycerate dehydrogenase (PHGDH) to human chromosome band 1p12 by fluorescence in situ hybridization
    Cytogenetic and Genome Research, vol. 89, no. 1-2, pp. 6–7, 2000
  52. Aged Mice Exhibit Greater Mortality Concomitant to Increased Brain and Plasma TNF-α Levels following Intracerebroventricular Injection of Lipopolysaccharide
    Gerontology, vol. 46, no. 3, pp. 115–128, 2000
  53. Use of Neuroendocrine Hormones to Promote Reconstitution after Bone Marrow Transplantation
    Neuroimmunomodulation, vol. 6, no. 1-2, pp. 69–80, 1999
  54. Phenotypic and functional characterization of lymphocytes derived from normal and HIV-1-infected human lymph nodes
    Clinical and Experimental Immunology, vol. 117, no. 1, pp. 92–99, 1999
  55. Generation of Artificial Proteoglycans Containing Glycosaminoglycan-modified CD44. DEMONSTRATION OF THE INTERACTION BETWEEN RANTES AND CHONDROITIN SULFATE
    Journal of Biological Chemistry, vol. 274, no. 4, pp. 2518–2524, 1999
  56. CD40 Stimulation Promotes Human Secondary Immunoglobulin Responses in HuPBL-SCID Chimeras
    Clinical Immunology, vol. 90, no. 1, pp. 22–27, 1999
  57. Cocaine Enhances Brain Endothelial Adhesion Molecules and Leukocyte Migration
    Clinical Immunology, vol. 91, no. 1, pp. 68–76, 1999
  58. Treatment with Tumor Necrosis Factor-a and Granulocyte–Macrophage Colony-Stimulating Factor Increases Epidermal Langerhans' Cell Numbers in Cancer Patients
    Clinical Immunology, vol. 93, no. 3, pp. 209–221, 1999
  59. The CC Chemokine I-309 Inhibits CCR8-dependent Infection by Diverse HIV-1 Strains
    Journal of Biological Chemistry, vol. 273, no. 1, pp. 386–391, 1998
  60. Identification and Characterization of Small Molecule Functional Antagonists of the CCR1 Chemokine Receptor
    Journal of Biological Chemistry, vol. 273, no. 25, pp. 15687–15692, 1998
  61. Opiates Transdeactivate Chemokine Receptors: delta and Opiate Receptor-mediated Heterologous Desensitization
    Journal of Experimental Medicine, vol. 188, no. 2, pp. 317–325, 1998
  62. Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family
    Gene, vol. 221, no. 1, pp. 135–142, 1998
  63. Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1? is mediated by the chemokine receptor CXCR4
    Current Biology, vol. 8, no. 10, pp. 595–598, 1998
  64. Opiate Inhibition of Chemokine-Induced Chemotaxis
    Annals of the New York Academy of Sciences, vol. 840, no. 1 NEUROIMMUNOMO, pp. 9–20, 1998
  65. CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons
    Current Biology, vol. 7, no. 2, pp. 112–121, 1997
  66. Chemokines induce migrational responses in human breast carcinoma cell lines
    International Journal of Cancer, vol. 71, no. 2, pp. 257–266, 1997
  67. MIGRATION RESPONSES OF HUMAN MONOCYTIC CELL LINES TO a- AND ß-CHEMOKINES
    Cytokine, vol. 9, no. 7, pp. 521–528, 1997
  68. IL-8-Induced T-Lymphocyte Migration: Direct as Well as Indirect Mechanisms
    Methods, vol. 10, no. 1, pp. 135–144, 1996
  69. The huPBL-SCID mouse as a means to examine human immune functionin vivo
    Seminars in Immunology, vol. 8, no. 4, pp. 233–241, 1996
  70. Generation of Antigenic Peptides by Lymphocyte Granule Serine Proteases (Granzymes),
    Cellular Immunology, vol. 172, no. 2, pp. 235–245, 1996
  71. THE CHEMOKINE C10: IMMUNOLOGICAL AND FUNCTIONAL ANALYSIS OF THE SEQUENCE ENCODED BY THE NOVEL SECOND EXON
    Cytokine, vol. 8, no. 6, pp. 439–447, 1996
  72. OVERRIDING THE BRAIN'S INTRINSIC RESISTANCE TO LEUKOCYTE RECRUITMENT WITH INTRAPARENCHYMAL INJECTIONS OF RECOMBINANT CHEMOKINES
    Neuroscience, vol. 74, no. 1, pp. 283–292, 1996
  73. Chemokine-leukocyte interactions. The voodoo that they do so well
    Cytokine & Growth Factor Reviews, vol. 7, no. 4, pp. 355–376, 1996
  74. Recombinant Human Adenovirus with Rat MIP-2 Gene Insertion Causes Prolonged PMN Recruitment to the Murine Brain
    European Journal of Neuroscience, vol. 8, no. 9, pp. 1803–1811, 1996
  75. Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils
    Journal of Biological Chemistry, vol. 271, no. 6, pp. 2935–2940, 1996
  76. Granulocyte-Colony Stimulating Factor and Lipopolysaccharide Regulate the Expression of Interleukin 8 Receptors on Polymorphonuclear Leukocytes
    Journal of Biological Chemistry, vol. 270, no. 47, pp. 28188–28192, 1995
  77. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo
    Journal of Experimental Medicine, vol. 182, no. 1, pp. 155–162, 1995
  78. Transfer of myeloma idiotype-specific immunity from an actively immunised marrow donor
    The Lancet, vol. 345, no. 8956, pp. 1016–1020, 1995
  79. Chemotaxis of T lymphocytes on extracellular matrix proteins Analysis of the in vitro method to quantitate chemotaxis of human T cells
    Journal of Immunological Methods, vol. 184, no. 2, pp. 187–198, 1995
  80. CD28:B7 interactions promote T cell adhesion
    European Journal of Immunology, vol. 25, no. 11, pp. 3087–3093, 1995
  81. Human RANTES induces the migration of human T lymphocytes into the peripheral tissues of mice with severe combined immune deficiency
    European Journal of Immunology, vol. 24, no. 8, pp. 1823–1827, 1994
  82. Review Of The Chemokine Meeting The Third International Symposium Of Chemotactic Cytokines
    Cytokine, vol. 5, no. 3, pp. 175–179, 1993
  83. Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells
    Journal of Experimental Medicine, vol. 177, no. 6, pp. 1809–1814, 1993
  84. Methylxanthine-induced inhibition of the antigen- and superantigen-specific activation of T and B lymphocytes
    Immunopharmacology, vol. 24, no. 3, pp. 203–217, 1992
  85. Effect of isotypic and allotypic variations of MHC class II molecules on staphylococcal enterotoxin presentation to murine T cells
    Cellular Immunology, vol. 141, no. 2, pp. 263–278, 1992
  86. Direct activation of murine T cells by staphylococcal enterotoxins*1
    Cellular Immunology, vol. 140, no. 2, pp. 267–281, 1992
  87. Characterization of antigen-specific suppressor factors induced by staphylococcal enterotoxin B*1
    Cellular Immunology, vol. 134, no. 1, pp. 216–224, 1991
  88. Immunomodulatory Activity of  - and  -Selective Opiod Agonists
    Proceedings of the National Academy of Sciences, vol. 88, no. 2, pp. 360–364, 1991
  89. Immunosuppressive activity of staphylococcal enterotoxin B *1I. Characterization of staphylococcal enterotoxin-B-induced suppressor cells
    Cellular Immunology, vol. 131, no. 1, pp. 159–169, 1990
  90. Immunosuppressive activity of staphylococcal enterotoxin B *1II. Activation of suppressor-effector cells by a staphylococcal enterotoxin B-induced suppressor factor
    Cellular Immunology, vol. 131, no. 1, pp. 170–183, 1990
  91. The induction of T-suppressor cells with a soluble extract of
    Cellular Immunology, vol. 122, no. 1, pp. 71–82, 1989