Martin Holland graduated in biology at The University of York, York, UK, in 1984. The same year he joined the MRC Clinical Immunology Research Unit, Imperial College Faculty of Medicine where he researched in autoimmune nephritis. From 1985 to 1987, he studied for an M.S. degree in immunology at Kings College, Queen Mary College, and Chelsea College. In 1987, he joined LSHTM and studied for a Ph.D. degree in cellular immunity following ocular infection with Chlamydia trachomatis. This was followed by two postdoctoral positions in Edinburgh firstly at the Moredun Research Institute in retrovirology and then the Institute of Infection and Immunology Research to study intestinal nematode infestations. In June 2000, Holland rejoined LSHTM to continue studies on the immunology and pathogenesis of trachoma. From 2002 to 2010, he was based at the MRC laboratories in The Gambia, and since 2005 he led trachoma research based at the MRC laboratories. In June 2010, he returned to the UK and is currently based in London with continuing projects in Tanzania, Guinea Bissau, and The Gambia. Holland's current interests focus on the role of immunoregulation in development of trachomatous disease pathology and the characterization of immune responses to potential C. trachomatis vaccine candidates. In particular, he has studied conjunctival gene expression using microarray and quantitative RTPCR. This has led to the development of a number of research areas including investigating the role of NK cells in the response to Chlamydia trachomatis, the contribution of host genetics (in particular the role of KIR/HLA) to disease sequelae, and understanding the extent of pathogen diversity and its impact on clinical disease.
Biography Updated on 2 October 2011