Eberhard Korsching is PI of the Cancer and Complex Systems Research Group at the Institute of Bioinformatics of the University Hospital of Muenster, Muenster, Germany. The studies in chemistry and biochemistry were brought to perfection in a Ph.D. degree thesis on extracellular matrix research. The present work focus has evolved from wet lab based research in cell and molecular biology (in a clinical setting) towards theoretical methods in biology. The foundations of the present work and the focus on clinical questions were established during the long standing research work in pathology. The commitment to interdisciplinary research resulted in an ever growing research effort in theoretical biology, stimulated by the wealth of already existing mathematical and physical concepts. These concepts have been a source of inspiration in concrete research efforts in the field of breast and bone cancers. The present research program is centered on the biological reaction networks and how they form this robust and adaptive multicellular system. Beside these basic research efforts, which rely on simulation studies and analysis of array/sequence data sets, we apply those mechanistic insights to understand cancer formation and progression. Some further clinical projects focus on the definition of biological marker panels and quality standards.
Biography Updated on 3 November 2012