Chaochun Wei is currently an Associate Professor in Shanghai Jiao Tong University, Shanghai, China. He got his B.S. degree in mathematics from Beijing University, Beijing, China, and he obtained his S.D. degree in computer science from the Washington University in St. Louis, Mich, USA. His research interests cover models and algorithms for biological sequence analysis, including gene structure prediction, regulatory element finding, metagenomics and pathogen genomics, and high-performance computing in bioinformatics. Wei has published papers on PLoS Biology, genome research, bioinformatics, ISME J, BMC genomics, BMC bioinformatics, PLoS ONE, and so forth. His work on C. elegans gene prediction was the first gene prediction system to achieve 60% sensitivity in the exact prediction of proteins in multicellular organisms. That paper was published in Genome Research and was then reported by Nature Reviews Genetics as the research highlight. In gene prediction for the human genome, the sensitivity was increased from 15% to 45% and from 10% to 25% for the specificity at the gene level. 734 human genes were validated for their existence by experiments designed based on the gene prediction results. Recently, he has started research on next-generation-sequencing (NGS) data analysis system for genomics and metagenomics. He estimated that there are more than 9 million unique genes in the human gut, which is 400 times more than the number of human genes. A new ultrafast metagenome analysis system with a series of tools has been created to deal with the huge amount of short reads from NGS. Its metagenome sequence classification subsystem is 1500 times faster than that of the best existing systems with similar functions and with slightly higher accuracy.
Biography Updated on 3 November 2013