Andreas Herrmann

Andreas Herrmann received the Diploma from Humboldt University Berlin, Germany, in 1979. He received the Ph.D. and Habilitation degrees also from the Humboldt-University Berlin, Germany, in 1982 and 1986, respectively. From 1982 to 1993, he was an Assistant Research Professor in the Department of Biology at the Humboldt-University Berlin. He was a Postdoctoral Fellow at the Institute de Biologie-Physico Chimique, Paris, France, in 1986 and 1988, working with Professor Philippe Devaux on protein-mediated lipid translocation in biological membranes. In 1989, he was a Forgaty Postdoctoral Fellow at the National Institutes of Health, Bethesda, USA, investigating together with Dr. Robert Blumenthal protein-mediated membrane fusion of enveloped viruses. Since 1993 he is a Professor in molecular biophysics at the Department of Biology of the Humboldt-University Berlin. In 2001, he was awarded the Prix Gay/Lussac of the French Ministry of Research. Currently, he is the coordinator of an EU Research Training Network on Lipid Flippases. The research is interdisciplinary ranging from structural biology, molecular and cell biology, virology, spectroscopy to the design and synthesis of biomolecule analogues. Although the main emphasis is on experimental research, his group has a very strong attraction to collaboration in theoretical modelling and simulation of experimental systems. Major research projects are related to protein-mediated fusion of biological membranes, membrane budding and virus assembly, lipid transporters and flippases, interaction of amyloid-proteins with membranes, nanobiotechnology. His teaching activities cover lectures and seminars in molecular biophysics, cell biophysics, and statistics. He is responsible for organization of a three-year Bachelor and a two-year Master course in biophysics.

Biography Updated on 15 January 2008

Personal Home Page

https://www.idi-berlin.de/index.php?option=com_faculty&Itemid=217

Articles in Scholarly Journals [Incomplete List]

  1. Conformational change of influenza virus hemagglutinin is sensitive to ionic concentration
    European Biophysics Journal, vol. 36, no. 4-5, pp. 327–335, 2007
  2. Lipophilic Oligonucleotides Spontaneously Insert into Lipid Membranes, Bind Complementary DNA Strands, and Sequester into Lipid-Disordered Domains
    Langmuir, vol. 23, no. 8, pp. 4455–4464, 2007
  3. Flippase Activity Detected with Unlabeled Lipids by Shape Changes of Giant Unilamellar Vesicles
    Journal of Biological Chemistry, vol. 282, no. 21, pp. 15559–15568, 2007
  4. ATP-driven MalK Dimer Closure and Reopening and Conformational Changes of the "EAA" Motifs Are Crucial for Function of the Maltose ATP-binding Cassette Transporter (MalFGK2)
    Journal of Biological Chemistry, vol. 282, no. 31, pp. 22387–22396, 2007
  5. The relevance of salt bridges for the stability of the influenza virus hemagglutinin
    The FASEB Journal, vol. 21, no. 4, pp. 995–1002, 2007
  6. Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS)
    Genes & Development, vol. 20, no. 19, pp. 2660–2672, 2006
  7. Interaction of huntingtin fragments with brain membranes - clues to early dysfunction in Huntington's disease
    Journal of Neurochemistry, vol. 96, no. 3, pp. 870–884, 2006
  8. ATP Induces Conformational Changes of Periplasmic Loop Regions of the Maltose ATP-binding Cassette Transporter
    Journal of Biological Chemistry, vol. 281, no. 7, pp. 3856–3865, 2006
  9. Lipid-Anchored Oligonucleotides for Stable Double-Helix Formation in Distinct Membrane Domains
    Angewandte Chemie International Edition, vol. 45, no. 27, pp. 4440–4444, 2006
  10. The bovine seminal plasma protein PDC-109 extracts phosphorylcholine-containing lipids from the outer membrane leaflet
    European Biophysics Journal, vol. 36, no. 4-5, pp. 461–475, 2006
  11. Function of prokaryotic and eukaryotic ABC proteins in lipid transport
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2005
  12. StarD10, a START Domain Protein Overexpressed in Breast Cancer, Functions as a Phospholipid Transfer Protein
    Journal of Biological Chemistry, vol. 280, no. 29, pp. 27436–27442, 2005
  13. Headgroup-specific Exposure of Phospholipids in ABCA1-expressing Cells
    Journal of Biological Chemistry, vol. 280, no. 28, pp. 26321–26329, 2005
  14. Intracellular interaction between syntaxin and Munc 18-1 revealed by fluorescence resonance energy transfer
    Molecular Membrane Biology, vol. 22, no. 5, pp. 401–410, 2005
  15. Localization of phosphatidylserine in boar sperm cell membranes during capacitation and acrosome reaction
    Reproduction, vol. 130, no. 5, pp. 615–626, 2005
  16. Bilayer Conformation of Fusion Peptide of Influenza Virus Hemagglutinin: A Molecular Dynamics Simulation Study
    Biophysical Journal, vol. 87, no. 1, pp. 14–22, 2004
  17. Desmosterol May Replace Cholesterol in Lipid Membranes
    Biophysical Journal, vol. 88, no. 3, pp. 1838–1844, 2004
  18. Asymmetric Addition of Ceramides but not Dihydroceramides Promotes Transbilayer (Flip-Flop) Lipid Motion in Membranes
    Biophysical Journal, vol. 88, no. 1, pp. 348–359, 2004
  19. Lipidic Pore Formation by the Concerted Action of Proapoptotic BAX and tBID
    Journal of Biological Chemistry, vol. 279, no. 29, pp. 30081–30091, 2004
  20. The Journal of Physical Chemistry B, vol. 108, no. 41, pp. 16279–16287, 2004
  21. Lipophilic Nucleosides by Sonogashira Coupling
    Synthesis, vol. 2004, no. 14, pp. 2335–2341, 2004
  22. Biochemistry, vol. 43, no. 2, pp. 464–472, 2004
  23. Enhanced exposure of phosphatidylserine in human gastric carcinoma cells overexpressing the half-size ABC transporter BCRP (ABCG2)
    Biochemical Journal, vol. 376, no. 2, p. 489, 2003
  24. The synaptophysin/synaptobrevin interaction critically depends on the cholesterol content
    Journal of Neurochemistry, vol. 84, no. 1, pp. 35–42, 2003
  25. Aminophospholipids Have No Access to the Luminal Side of the Biliary Canaliculus: IMPLICATIONS FOR THE SPECIFIC LIPID COMPOSITION OF THE BILE FLUID
    Journal of Biological Chemistry, vol. 278, no. 42, pp. 40631–40639, 2003
  26. Signal Transduction in the Visual Cascade Involves Specific Lipid-Protein Interactions
    Journal of Biological Chemistry, vol. 278, no. 25, pp. 22853–22860, 2003
  27. The Potential of Fluorescent and Spin-labeled Steroid Analogs to Mimic Natural Cholesterol
    Journal of Biological Chemistry, vol. 278, no. 46, pp. 45563–45569, 2003
  28. Early steps of the conformational change of influenza virus hemagglutinin to a fusion active state Stability and energetics of the hemagglutinin
    Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 1614, no. 1, pp. 3–13, 2003
  29. Rapid transport of phospholipids across the plasma membrane of Leishmania infantum
    Biochemical and Biophysical Research Communications, vol. 306, no. 1, pp. 250–255, 2003
  30. Analysis of the lipid composition of bull spermatozoa by MALDI-TOF mass spectrometry—a cautionary note
    Chemistry and Physics of Lipids, vol. 126, no. 1, pp. 85–94, 2003
  31. Reversal of breast cancer resistance protein-mediated drug resistance by tryprostatin A
    International Journal of Cancer, vol. 107, no. 5, pp. 721–728, 2003
  32. The 3D structure of the fusion primed Sendai F-protein determined by electron cryomicroscopy
    The EMBO Journal, vol. 22, no. 15, pp. 3761–3771, 2003
  33. Influence of the bovine seminal plasma protein PDC-109 on cholesterol in the presence of phospholipids
    European Biophysics Journal, vol. 31, no. 6, pp. 438–447, 2002
  34. Lysolipids Do Not Inhibit Influenza Virus Fusion by Interaction with Hemagglutinin
    Journal of Biological Chemistry, vol. 277, no. 23, pp. 20461–20467, 2002
  35. Rapid Nonvesicular Transport of Sterol between the Plasma Membrane Domains of Polarized Hepatic Cells
    Journal of Biological Chemistry, vol. 277, no. 33, pp. 30325–30336, 2002
  36. Transport of phosphatidylserine via MDR1 (multidrug resistance 1)P-glycoprotein in a human gastric carcinoma cell line
    Biochemical Journal, vol. 365, no. 1, p. 259, 2002
  37. Biochemistry, vol. 41, no. 17, pp. 5605–5612, 2002
  38. Biochemistry, vol. 41, no. 43, pp. 13106–13115, 2002
  39. Light-induced Reorganization of Phospholipids in Rod Disc Membranes
    Journal of Biological Chemistry, vol. 276, no. 4, pp. 2538–2543, 2001
  40. Degradation of natural polyphenols by methanogenic consortia enriched from digested municipal sludge
    Water Research, vol. 35, no. 11, pp. 2575–2582, 2001
  41. Cofermentation of rutin and hesperidin during two-stage anaerobic pre-treatment of high-loaded brewery wastewater
    Water Research, vol. 35, no. 11, pp. 2583–2588, 2001
  42. Continuous measurement of rapid transbilayer movement of a pyrene-labeled phospholipid analogue
    Chemistry and Physics of Lipids, vol. 106, no. 1, pp. 89–99, 2000
  43. Binding Properties of Agonists and Antagonists to Distinct Allosteric States of the Nicotinic Acetylcholine Receptor Are Incompatible with a Concerted Model
    Journal of Biological Chemistry, vol. 275, no. 39, pp. 30196–30201, 2000
  44. Membrane transport: Deciphering fusion
    Current Biology, vol. 10, no. 20, pp. R750–R752, 2000
  45. Biochemistry, vol. 39, no. 17, pp. 4994–5003, 2000
  46. The transbilayer distribution of phospholipids in disc membranes is a dynamic equilibrium. Evidence for rapid flip and flop movement
    European Journal of Biochemistry, vol. 267, no. 5, pp. 1473–1483, 2000
  47. Phagocytic Clearance of Apoptotic Neurons by Microglia/Brain Macrophages In Vitro. Involvement of Lectin-, Integrin-, and Phosphatidylserine-Mediated Recognition
    Journal of Neurochemistry, vol. 75, no. 3, pp. 1060–1070, 2000
  48. Modification of the Cytoplasmic Domain of Influenza Virus Hemagglutinin Affects Enlargement of the Fusion Pore
    Journal of Virology, vol. 74, no. 16, pp. 7529–7537, 2000
  49. Internalization of Phospholipids from the Plasma Membrane of Human Osteoblasts Depends on the Lipid Head Group
    Journal of Bone and Mineral Research, vol. 14, no. 5, pp. 690–699, 1999
  50. Rapid transbilayer movement of fluorescent phospholipid analogues in the plasma membrane of endocytosis-deficient yeast cells does not require the Drs2 protein
    European Journal of Biochemistry, vol. 263, no. 1, pp. 254–264, 1999
  51. Biochemistry, vol. 38, no. 1, pp. 142–150, 1999
  52. Structure of influenza haemagglutinin at neutral and at fusogenic pH by electron cryo-microscopy
    FEBS Letters, vol. 463, no. 3, pp. 255–259, 1999
  53. Lipid domains in the exoplasmic and cytoplasmic leaflet of the human erythrocyte membrane: a spin label approach
    European Biophysics Journal, vol. 28, no. 4, pp. 302–311, 1999
  54. Biophysical characterization of the interaction of bovine seminal plasma protein PDC-109 with phospholipid vesicles
    European Biophysics Journal, vol. 27, no. 1, pp. 33–41, 1998
  55. Acylation of the Influenza Hemagglutinin Modulates Fusion Activity
    Virology, vol. 248, no. 2, pp. 284–294, 1998
  56. Biochemistry, vol. 37, no. 48, pp. 17093–17103, 1998
  57. Biochemistry, vol. 36, no. 4, pp. 839–847, 1997
  58. Transient Changes of the Conformation of Hemagglutinin of Influenza Virus at Low pH Detected by Time-resolved Circular Dichroism Spectroscopy
    Journal of Biological Chemistry, vol. 272, no. 15, pp. 9764–9770, 1997
  59. Interaction of Earthworm Hemolysin with Lipid Membranes Requires Sphingolipids
    Journal of Biological Chemistry, vol. 272, no. 33, pp. 20884–20892, 1997
  60. Modelling of Phospholipid Translocation in the Erythrocyte Membrane: A Combined Kinetic and Thermodynamic Approach
    Journal of Theoretical Biology, vol. 185, no. 3, pp. 295–312, 1997
  61. Targeted delivery of human neurofibromin and c-Raf-1 mutants to the cytoplasmic membrane by use of the influenza virus hemagglutinin
    Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, vol. 1338, no. 2, pp. 233–243, 1997
  62. ATP-dependent redistribution of phosphatidylethanolamine in the plasma membrane of an epithelial and a hepatocytic cell line
    Pflügers Archiv European Journal of Physiology, vol. 431, no. S6, pp. R243–R244, 1996
  63. Transverse mobility of aminophospholipids in the plasma membrane of ram sperm cells
    Pflügers Archiv European Journal of Physiology, vol. 431, no. S6, pp. R255–R256, 1996
  64. Deacylation of influenza virus hemagglutinin does not affect the kinetics of low pH induced membrane fusion
    Pflügers Archiv European Journal of Physiology, vol. 431, no. S6, pp. R257–R258, 1996
  65. An improved assay for measuring the transverse redistribution of fluorescent phospholipids in plasma membranes
    Chemistry and Physics of Lipids, vol. 77, no. 2, pp. 139–146, 1995
  66. Structure and Topology of the Influenza Virus Fusion Peptide in Lipid Bilayers
    Journal of Biological Chemistry, vol. 270, no. 46, pp. 27606–27614, 1995
  67. Biochemistry, vol. 33, no. 33, pp. 9968–9974, 1994
  68. On the validity of lipid dequenching assays for estimating virus fusion kinetics
    Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 1190, no. 2, pp. 360–366, 1994
  69. Incorporation of Phospholipid Analogs into the Plasma Membrane Affects ATP-Induced Vesiculation of Human Erythrocyte Ghosts
    Biochemical and Biophysical Research Communications, vol. 199, no. 2, pp. 881–887, 1994
  70. The influence of poly(ethylene glycol) on the molecular dynamics within the glycocalyx
    Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 980, no. 2, pp. 146–154, 1989
  71. Are osmotic forces involved in influenza virus-cell fusion?
    Bioscience Reports, vol. 8, no. 1, pp. 55–64, 1988
  72. The influenza virus-induced fusion of erythrocyte ghosts does not depend on osmotic forces
    Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 943, no. 3, pp. 411–418, 1988
  73. Phospholipid outside-inside translocation in lymphocyte plasma membranes is a protein-mediated phenomenon
    Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 897, no. 1, pp. 197–200, 1987
  74. The influence of the antiviral drugs amantadine and rimantadine on erythrocyte and platelet membranes and its comparison with that of tetracaine
    Biochemical Pharmacology, vol. 36, no. 4, pp. 481–487, 1987
  75. Correlation of the internal microviscosity of human erythrocytes to the cell volume and the viscosity of hemoglobin solutions
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol. 885, no. 1, pp. 80–87, 1986
  76. Conformational alterations within the glycocalyx of erythrocyte membranes studied by spin labelling
    Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 861, no. 1, pp. 111–121, 1986
  77. Structural alterations of the human erythrocyte membrane upon influenza virus attachment
    Bioscience Reports, vol. 6, no. 1, pp. 45–55, 1986
  78. Further evidence for a membrane potential-dependent shape transformation of the human erythrocyte membrane
    Bioscience Reports, vol. 6, no. 11, pp. 999–1006, 1986
  79. Ionic strength-dependent alterations of membrane structure of red blood cells
    Bioscience Reports, vol. 6, no. 11, pp. 1007–1015, 1986
  80. Shape transformation of erythrocyte ghosts depends on ion concentrations
    Bioscience Reports, vol. 5, no. 5, pp. 417–423, 1985
  81. Influence of the intracellular and extracellular cation concentration on monovalent cation efflux of resealed human erythrocyte ghosts
    Bioscience Reports, vol. 5, no. 5, pp. 425–432, 1985
  82. The effect of osmotic pressure of aqueous PEG solutions on red blood cells
    Bioscience Reports, vol. 5, no. 8, pp. 689–696, 1985
  83. The dielectric properties of aqueous solutions of poly(ethylene glycol) and their influence on membrane structure
    Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 815, no. 3, pp. 515–518, 1985
  84. Spectroscopic characterization of vesicle formation on heated human erythrocytes and the influence of the antiviral agent amantadine
    Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 812, no. 1, pp. 277–285, 1985