Rodolfo Testa was born in Milano, Italy, in 1947. He received the Diploma of nongraduate chemist and the B.S. degree from the University of Milan, Italy, in 1966 and 1976, respectively. From 1968 to 1970, he was a Research Fellow at the Mario Negri Institute of Pharmacological Research. From 1970 to 1980, he was a Researcher at the Istituto Franco Tosi SpA-Milano. From 1980 to 1989, he was a Researcher at the Recordati Spa-Milano and became the Head of the Pharmacological Department of the company in 1990. He has been retired since 2005 and, at present, is a member of F1000 Faculty (Genito-Urinary and Reproductive Pharmacology Section, Pharmacology and Drug Discovery Faculty). During the working period in Recordati, Testa was interested in synthesis and screening of new potent and selective antagonists at the alpha1 adrenergic receptor subtypes, selective 5-HT(1A) receptor antagonists, and noncompetitive inhibitors of metabotropic glutamate receptor 5. He extensively studied the involvement of the alpha1 adrenergic receptor subtypes in the contraction of lower urinary tract tissues as well as the activity of selective antagonists on tilt-induced changes in blood pressure in relation to uroselectivity and penile erection in anesthetized rats and dogs. Moreover, he also studied the effect of different agents on micturition reflex in healthy animals and in animals with bladder outlet obstruction, including 5-HT(1A) receptor antagonists, antimuscarinics, cyclooxygenase inhibitors, alpha1 adrenergic receptor antagonists, and group I metabotropic glutamate receptor antagonists. A review of mechanisms potentially available for the improved control of lower urinary tract and and pain has been recently published by Testa and T. Mennini from Mario Negri Institute. The cardiovascular and renal effects of dihydropyridine-type Ca2+ antagonists were also matter of interest of Testa.
Biography Updated on 15 November 2011