Ynuk Bossé (PhD) -2007-2012: Post-doctoral training in smooth muscle and airway mechanics at the James Hogg Research Center, Vancouver, BC, Canada -11/2010-02/2011: Post-doctoral training in airway and lung physiology at the Woolcock Institute of Medical Research, Sydney, NSW, Australia -2002/2007: Doctoral training in Immunology at Sherbrooke University on the excessive proliferation of bronchial smooth muscle cells in asthma, Sherbrooke, Qc, Canada -2000-2002: Master’s degree in Kinesiology at Laval University on the antioxidant enzymes in skeletal muscle, Québec, Qc, Canada -1995-2000: Bachelor’s degree in Physical Education and Biology at Moncton University, Moncton, NB, Canada Dr Bossé has been studying asthma for the last 10 years. His main interest is to understand the role played by the airway smooth muscle in the manifestation of asthma symptoms and airway hypperresponsiveness. Dr Bossé studies airway smooth muscle in vitro (in cell culture), ex vivo (in organ bath) and in vivo (in human). His current work focuses on the effects of lung alterations found in asthma on airway smooth contractile properties, such as its force-generating capacity, maximal amount of shortening, velocity of shortening, stiffness, and ability to relax as well as to tolerate and recover from oscillating stress that stimulates breathing maneuvers. Dr Bossé and his team has recently discovered and described a phenomenon dubbed ‘force adaptation’, a process by which the airway smooth muscle acquires incremental capabilities to generate force during a sustained exposure to a contractile agonist (spasmogen). Dr Bossé believes that ‘force adaptation’ is a common contributor to airway hyperresponsiveness in asthma.
Biography Updated on 4 October 2012