Phil has a strong background in molecular cytogenetics. Having graduated from the University of Sussex with a Bachelor of Science with honours, he worked in the University Hospital of Wales as a clinical cytogeneticist identifying chromosomal anomalies in relation to different clinical outcomes such as pre natal diagnosis, infertility and cancer assessment. Phil then founded the florescent in situ hybridisation laboratory in the genetics department at the University of Cambridge before moving to Australia. He then worked in cytogenetic laboratories both in Adelaide and Queensland before returning to South Australia to take a position at CSIRO in 1998 in the Genome Health and Nutrigenomic laboratory at CSIRO Division of Human Nutrition headed by Professor Michael Fenech. His role primarily was one of a molecular cytogeneticist, Phil has more than ten years experience in various molecular cytogenetic techniques such as FISH that have been used to assess genomic instability events in various different tissue types Phil was awarded his PhD in February 2008 investigating changes in buccal cytome biomarkers in relation to ageing and Alzheimer’s disease. The thesis developed a non-invasive method to determine DNA damage, cell death and cellular proliferation potential within the buccal cell mucosa. The resulting buccal cytome micronucleus assay was validated and showed significant changes in the cellular kinetics and structural profile of the buccal mucosa as a result of normal ageing and in premature ageing syndromes such as Down syndrome and Alzheimer’s disease. Further buccal cell biomarkers have been identified such as aneuploidy and telomere length which were investigated in various tissued from AD cohorts and found to be significant He continues to work at the CSIRO as a research scientist and maintains his interest in genomic instability events in relation to neurodegeneration.
Biography Updated on 21 May 2012