Michael L. Bittner

Michael L. Bittner has done research on the practical applications of biotechnology in the fields of bioproduction of proteins, peptides, and small molecules, and in development of clinical diagnostics and therapeutics. He has been a Researcher in both corporate (Monsanto, Amoco) and research institute (NIH, TGen) settings.

Biography Updated on 18 May 2006

Articles in Scholarly Journals [Incomplete List]

  1. A Robust Structural PGN Model for Control of Cell-Cycle Progression Stabilized by Negative Feedbacks
    EURASIP Journal on Bioinformatics and Systems Biology, vol. 2007, Article ID 73109, 11 pages, 2007
  2. Validation of Computational Methods in Genomics
    Current Genomics, vol. 8, no. 1, pp. 1–19, 2007
  3. Normalization Benefits Microarray-Based Classification
    EURASIP Journal on Bioinformatics and Systems Biology, vol. 2006, Article ID 43056, 13 pages, 2006
  4. Generating Boolean networks with a prescribed attractor structure
    Bioinformatics, vol. 21, no. 21, pp. 4021–4025, 2005
  5. Intervention in a family of Boolean networks
    Bioinformatics, vol. 22, no. 2, pp. 226–232, 2005
  6. A window on the dynamics of biological switches
    Nature Biotechnology, vol. 23, no. 2, Article ID nbt0205-183, 1 pages, 2005
  7. Stress-specific signatures: expression profiling of p53 wild-type and -null human cells
    Oncogene, vol. 24, no. 28, Article ID 1208653, 7 pages, 2005
  8. Generation and analysis of melanoma SAGE libraries: SAGE advice on the melanoma transcriptome
    Oncogene, vol. 23, no. 12, Article ID 1207337, 10 pages, 2004
  9. Functional genomics of UV radiation responses in human cells
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 549, no. 1-2, pp. 65–78, 2004
  10. External control in Markovian genetic regulatory networks: the imperfect information case
    Bioinformatics, vol. 20, no. 6, pp. 924–930, 2004
  11. Growing genetic regulatory networks from seed genes
    Bioinformatics, vol. 20, no. 8, pp. 1241–1247, 2004
  12. Which is better for cDNA-microarray-based classification: ratios or direct intensities
    Bioinformatics, vol. 20, no. 16, pp. 2513–2520, 2004
  13. A Bayesian connectivity-based approach to constructing probabilistic gene regulatory networks
    Bioinformatics, vol. 20, no. 17, pp. 2918–2927, 2004
  14. Intervention in context-sensitive probabilistic Boolean networks
    Bioinformatics, vol. 21, no. 7, pp. 1211–1218, 2004
  15. Boolean relationships among genes responsive to ionizing radiation in the NCI 60 ACDS
    Bioinformatics, vol. 21, no. 8, pp. 1542–1549, 2004
  16. Genomic Signal Processing: The Salient Issues
    EURASIP Journal on Applied Signal Processing, vol. 2004, no. 1, pp. 146–153, 2004
  17. Noise factor analysis for cDNA microarrays
    Journal of Biomedical Optics, vol. 9, no. 4, p. 663, 2004
  18. Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease
    Human Molecular Genetics, vol. 12, no. 17, pp. 2191–2199, 2003
  19. Efficient selection of feature sets possessing high coefficients of determination based on incremental determinations
    Signal Processing, vol. 83, no. 4, pp. 695–712, 2003
  20. Machine Learning, vol. 52, no. 1/2, pp. 169–191, 2003
  21. Gene-expression profiling in human cutaneous melanoma
    Oncogene, vol. 22, no. 20, Article ID 1206448, 4 pages, 2003
  22. Functional genomics as a window on radiation stress signaling
    Oncogene, vol. 22, no. 37, Article ID 1206681, 5 pages, 2003
  23. Mutation of melanosome protein RAB38 in chocolate mice
    Proceedings of the National Academy of Sciences, vol. 99, no. 7, pp. 4471–4476, 2002
  24. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma
    Cancer Cell, vol. 1, no. 3, pp. 279–288, 2002
  25. Inference from Clustering with Application to Gene-Expression Microarrays
    Journal of Computational Biology, vol. 9, no. 1, pp. 105–126, 2002
  26. Strong Feature Sets from Small Samples
    Journal of Computational Biology, vol. 9, no. 1, pp. 127–146, 2002
  27. Assessing the significance of consistently mis-regulated genes in cancer associated gene expression matrices
    Bioinformatics, vol. 18, no. 3, pp. 389–394, 2002
  28. Ratio statistics of gene expression levels and applications to microarray data analysis
    Bioinformatics, vol. 18, no. 9, pp. 1207–1215, 2002
  29. Simulation of cDNA microarrays via a parameterized random signal model
    Journal of Biomedical Optics, vol. 7, no. 3, p. 507, 2002
  30. Journal of Biological Systems, vol. 10, no. 4, p. 337, 2002
  31. Induction of Gene Expression as a Monitor of Exposure to Ionizing Radiation
    Radiation Research, vol. 156, no. 5, p. 657, 2001
  32. Transcription Program of Human Herpesvirus 8 (Kaposi's Sarcoma-Associated Herpesvirus)
    Journal of Virology, vol. 75, no. 10, pp. 4843–4853, 2001
  33. Biological indicators for the identification of ionizing radiation exposure in humans
    Expert Review of Molecular Diagnostics, vol. 1, no. 2, pp. 211–219, 2001
  34. The Ca2+-binding Proteins S100A8 and S100A9 Are Encoded by Novel Injury-regulated Genes
    Journal of Biological Chemistry, vol. 276, no. 38, pp. 35818–35825, 2001
  35. Physiological function as regulation of large transcriptional programs: the cellular response to genotoxic stress
    Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, vol. 129, no. 4, pp. 703–710, 2001
  36. Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer
    Proceedings of the National Academy of Sciences, vol. 98, no. 10, pp. 5711–5716, 2001
  37. Gene-Expression Profiles in Hereditary Breast Cancer
    New England Journal of Medicine, vol. 344, no. 8, pp. 539–548, 2001
  38. Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-?B activation
    Oncogene, vol. 20, no. 33, Article ID 1204513, 12 pages, 2001
  39. Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling
    Oncogene, vol. 20, no. 46, Article ID 1204889, 5 pages, 2001
  40. Nature, vol. 406, no. 6795, pp. 536–540, 2000
  41. Chromosome arm-specific multicolor FISH
    Genes, Chromosomes and Cancer, vol. 30, no. 1, pp. 105–109, 2000
  42. Identification of Tumor-Suppressor Genes Using Human Melanoma Cell Lines UACC903, UACC903(+6), and SRS3 by Comparison of Expression Profiles
    Molecular Carcinogenesis, vol. 28, no. 2, pp. 119–127, 2000
  43. Multivariate Measurement of Gene Expression Relationships
    Genomics, vol. 67, no. 2, pp. 201–209, 2000
  44. Positional Cloning Utilizing Genomic DNA Microarrays: The Niemann–Pick Type C Gene as a Model System
    Molecular Genetics and Metabolism, vol. 70, no. 1, pp. 10–18, 2000
  45. General nonlinear framework for the analysis of gene interaction via multivariate expression arrays
    Journal of Biomedical Optics, vol. 5, no. 4, p. 411, 2000
  46. Identification of Potential mRNA Biomarkers in Peripheral Blood Lymphocytes for Human Exposure to Ionizing Radiation
    Radiation Research, vol. 154, no. 3, p. 342, 2000
  47. Detecting Activation of Ribosomal Protein S6 Kinase by Complementary DNA and Tissue Microarray Analysis
    Journal of the National Cancer Institute, vol. 92, no. 15, pp. 1252–1259, 2000
  48. Differentially Painting Human Chromosome Arms with Combined Binary Ratio-labeling Fluorescence In Situ Hybridization
    Genome Research, vol. 10, no. 6, pp. 861–865, 2000
  49. Microarrays and toxicology: The advent of toxicogenomics
    Molecular Carcinogenesis, vol. 24, no. 3, pp. 153–159, 1999
  50. Expression profiling in cancer using cDNA microarrays
    Electrophoresis, vol. 20, no. 2, pp. 223–229, 1999
  51. Nature Genetics, vol. 22, no. 3, pp. 213–215, 1999
  52. Expression profiling using cDNA microarrays
    Nature Genetics, vol. 21, Article ID 4434, 4 pages, 1999
  53. Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses
    Oncogene, vol. 18, no. 24, pp. 3666–3672, 1999
  54. Informatic selection of a neural crest-melanocyte cDNA set for microarray analysis
    Proceedings of the National Academy of Sciences, vol. 96, no. 16, pp. 9277–9280, 1999
  55. cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene
    Proceedings of the National Academy of Sciences, vol. 96, no. 23, pp. 13264–13269, 1999
  56. Nature Genetics, vol. 20, no. 1, pp. 19–23, 1998
  57. Chromosome Research, vol. 6, no. 1, pp. 25–33, 1998
  58. Comparative Genomic Hybridization: A Comparison with Molecular and Cytogenetic Analysis
    Cancer Genetics and Cytogenetics, vol. 100, no. 2, pp. 93–105, 1998
  59. Restriction Mapping of Recombinant Cosmid Clones Using ? Terminase and Field Inversion Gel Electrophoresis
    Analytical Biochemistry, vol. 245, no. 1, pp. 105–107, 1997
  60. A 2.8-Mb Clone Contig of the Multiple Endocrine Neoplasia Type 1 (MEN1) Region at 11q13
    Genomics, vol. 42, no. 3, pp. 436–445, 1997
  61. Functional human CFTR produced by stable Chinese hamster ovary cell lines derived using yeast artificial chromosomes
    Human Molecular Genetics, vol. 6, no. 1, pp. 59–68, 1997
  62. Molecular cytogenetic characterization and physical mapping of 12q13–15 amplification in human cancers
    Genes, Chromosomes and Cancer, vol. 17, no. 4, pp. 205–214, 1996
  63. Chromosome arm painting probes
    Nature Genetics, vol. 12, no. 1, Article ID ng0196-10, 1 pages, 1996
  64. Use of a cDNA microarray to analyse gene expression patterns in human cancer
    Nature Genetics, vol. 14, no. 4, Article ID ng1296-457, 3 pages, 1996
  65. Identification by Representational Difference Analysis of a Homozygous Deletion in Pancreatic Carcinoma that Lies within the BRCA2 Region
    Proceedings of the National Academy of Sciences, vol. 92, no. 13, pp. 5950–5954, 1995
  66. Expression, isolation and properties of Fur (ferric uptake regulation) protein ofEscherichia coli K 12
    Biology of Metals, vol. 1, no. 1, pp. 62–68, 1988
  67. Expression of Bacterial Genes in Plant Cells
    Proceedings of the National Academy of Sciences, vol. 80, no. 15, pp. 4803–4807, 1983