George King

Articles in Scholarly Journals [Incomplete List]

  1. Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes
    Nature Clinical Practice Endocrinology & Metabolism, vol. 3, no. 1, Article ID ncpendmet0366, 10 pages, 2007
  2. Summary statement IV: Obesity and diabetes: Opportunities for translation of basic research?
    Vascular Pharmacology, vol. 46, no. 5, pp. 324–326, 2007
  3. The role of protein kinase C activation and the vascular complications of diabetes
    Pharmacological Research, vol. 55, no. 6, pp. 498–510, 2007
  4. Effects of Insulin Replacements, Inhibitors of Angiotensin, and PKC 's Actions to Normalize Cardiac Gene Expression and Fuel Metabolism in Diabetic Rats
    Diabetes, vol. 56, no. 5, pp. 1410–1420, 2007
  5. Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia: Possible Contribution to Impaired Incretin Effects in Diabetes
    Diabetes, vol. 56, no. 6, pp. 1551–1558, 2007
  6. Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects
    The FASEB Journal, vol. 20, no. 12, pp. 2058–2067, 2006
  7. Clinical safety of the selective PKC-? inhibitor, ruboxistaurin
    Expert Opinion on Drug Safety, vol. 5, no. 6, pp. 835–845, 2006
  8. Regulation of Vascular Endothelial Growth Factor Expression and Vascularization in the Myocardium by Insulin Receptor and PI3K/Akt Pathways in Insulin Resistance and Ischemia
    Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 4, pp. 787–793, 2006
  9. Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPAR? agonist's effects on edema and weight gain
    The FASEB Journal, vol. 20, no. 8, pp. 1203–1205, 2006
  10. Reduction of Diabetes-Induced Oxidative Stress, Fibrotic Cytokine Expression, and Renal Dysfunction in Protein Kinase C -Null Mice
    Diabetes, vol. 55, no. 11, pp. 3112–3120, 2006
  11. Proatherosclerotic Mechanisms Involving Protein Kinase C in Diabetes and Insulin Resistance
    Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 3, pp. 487–496, 2005
  12. Role of p90 Ribosomal S6 Kinase (p90RSK) in Reactive Oxygen Species and Protein Kinase C   (PKC- )-mediated Cardiac Troponin I Phosphorylation
    Journal of Biological Chemistry, vol. 280, no. 25, pp. 24135–24142, 2005
  13. Differential Regulation of Angiotensin II-induced Expression of Connective Tissue Growth Factor by Protein Kinase C Isoforms in the Myocardium
    Journal of Biological Chemistry, vol. 280, no. 16, pp. 15719–15726, 2005
  14. The Effect of Vitamin E on Endothelial Function of Micro- and Macrocirculation and Left Ventricular Function in Type 1 and Type 2 Diabetic Patients
    Diabetes, vol. 54, no. 1, pp. 204–211, 2005
  15. Can Protein Kinase C  -Selective Inhibitor, Ruboxistaurin, Stop Vascular Complications in Diabetic Patients?
    Diabetes Care, vol. 28, no. 11, pp. 2803–2805, 2005
  16. Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications
    Current Diabetes Reports, vol. 5, no. 2, pp. 91–97, 2005
  17. Molecular Targets of Diabetic Cardiovascular Complications
    Current Drug Targets, vol. 6, no. 4, pp. 487–494, 2005
  18. Protein Kinase C� Isoform Inhibitors: A New Treatment for Diabetic Cardiovascular Diseases
    Circulation, vol. 110, no. 1, pp. 7–9, 2004
  19. Hyperglycemia-induced oxidative stress in diabetic complications
    Histochemistry and Cell Biology, vol. 122, no. 4, pp. 333–338, 2004
  20. Microvascular complications of diabetes
    Endocrinology & Metabolism Clinics of North America, vol. 33, no. 1, pp. 215–238, 2004
  21. Hyperglycemia Promotes Oxidative Stress through Inhibition of Thioredoxin Function by Thioredoxin-interacting Protein
    Journal of Biological Chemistry, vol. 279, no. 29, pp. 30369–30374, 2004
  22. Oxidative Stress and Antioxidant Treatment in Diabetes
    Annals of the New York Academy of Sciences, vol. 1031, no. 1, pp. 204–213, 2004
  23. Elevated C-Reactive Protein Levels Do Not Correspond to Autoimmunity in Type 1 Diabetes
    Diabetes Care, vol. 27, no. 11, pp. 2769–2770, 2004
  24. Role of Protein Kinase C on the Expression of Platelet-Derived Growth Factor and Endothelin-1 in the Retina of Diabetic Rats and Cultured Retinal Capillary Pericytes
    Diabetes, vol. 52, no. 3, pp. 838–845, 2003
  25. Characterization of Retinal Leukostasis and Hemodynamics in Insulin Resistance and Diabetes: Role of Oxidants and Protein Kinase-C Activation
    Diabetes, vol. 52, no. 3, pp. 829–837, 2003
  26. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance
    Journal of Clinical Investigation, vol. 111, no. 9, pp. 1373–1380, 2003
  27. Diabetic Retinopathy
    Diabetes Care, vol. 26, no. 1, pp. 226–229, 2003
  28. Thrombin Stimulation of Vascular Adhesion Molecule-1 in Endothelial Cells Is Mediated by Protein Kinase C (PKC)-delta -NF-kappa B and PKC-zeta -GATA Signaling Pathways
    Journal of Biological Chemistry, vol. 278, no. 9, pp. 6976–6984, 2003
  29. Characterization of Multiple Signaling Pathways of Insulin in the Regulation of Vascular Endothelial Growth Factor Expression in Vascular Cells and Angiogenesis
    Journal of Biological Chemistry, vol. 278, no. 34, pp. 31964–31971, 2003
  30. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization
    Journal of Clinical Investigation, vol. 111, no. 12, pp. 1835–1842, 2003
  31. Bariatric Surgery for Morbid Obesity
    JAMA: The Journal of the American Medical Association, vol. 289, no. 14, pp. 1779–1779, 2003
  32. Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications
    JAMA: The Journal of the American Medical Association, vol. 288, no. 20, pp. 2579–2588, 2002
  33. Decreased Cardiac Expression of Vascular Endothelial Growth Factor and Its Receptors in Insulin-Resistant and Diabetic States: A Possible Explanation for Impaired Collateral Formation in Cardiac Tissue
    Circulation, vol. 105, no. 3, pp. 373–379, 2002
  34. Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization
    Proceedings of the National Academy of Sciences, vol. 99, no. 2, pp. 721–726, 2002
  35. B-cell Signaling: Protein Kinase Cd Puts the Brakes on
    Current Biology, vol. 12, no. 16, pp. R554–R556, 2002
  36. Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C  2 Activation and Diabetes
    Diabetes, vol. 51, no. 9, pp. 2709–2718, 2002
  37. Diacylglycerol Production and Protein Kinase C Activity Are Increased in a Mouse Model of Diabetic Embryopathy
    Diabetes, vol. 51, no. 9, pp. 2804–2810, 2002
  38. Stretch-induced Retinal Vascular Endothelial Growth Factor Expression Is Mediated by Phosphatidylinositol 3-Kinase and Protein Kinase C (PKC)-zeta but Not by Stretch-induced ERK1/2, Akt, Ras, or Classical/Novel PKC Pathways
    Journal of Biological Chemistry, vol. 277, no. 2, pp. 1047–1057, 2002
  39. Involvement of Protein Kinase C beta 2 in c-myc Induction by High Glucose in Pancreatic beta -Cells
    Journal of Biological Chemistry, vol. 277, no. 5, pp. 3680–3685, 2002
  40. Protein kinase C and the development of diabetic vascular complications
    Diabetic Medicine, vol. 18, no. 12, pp. 945–959, 2001
  41. Human vascular smooth muscle cells of diabetic origin exhibit increased proliferation, adhesion, and migration
    Journal of Vascular Surgery, vol. 33, no. 3, pp. 601–607, 2001
  42. Pigment-Epithelium-Derived Factor -- A Key Coordinator of Retinal Neuronal and Vascular Functions
    New England Journal of Medicine, vol. 342, no. 5, pp. 349–351, 2000
  43. Vascular Endothelial Growth Factor Induces Expression of Connective Tissue Growth Factor via KDR, Flt1, and Phosphatidylinositol 3-Kinase-Akt-dependent Pathways in Retinal Vascular Cells
    Journal of Biological Chemistry, vol. 275, no. 52, pp. 40725–40731, 2000
  44. Identification of PKC-isoform-specific biological actions using pharmacological approaches
    Trends in Pharmacological Sciences, vol. 21, no. 5, pp. 181–187, 2000
  45. von Willebrand factor and retinal circulation in early-stage retinopathy of type 1 diabetes
    Diabetes Care, vol. 23, no. 11, pp. 1694–1698, 2000
  46. Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation
    Diabetes, vol. 49, no. 7, pp. 1239–1248, 2000
  47. High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes
    Diabetes Care, vol. 22, no. 8, pp. 1245–1251, 1999
  48. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells
    Diabetes, vol. 48, no. 5, pp. 1120–1130, 1999
  49. Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes
    Diabetes, vol. 48, no. 9, pp. 1856–1862, 1999
  50. d-a-Tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity
    Diabetes Research and Clinical Practice, vol. 45, no. 2-3, pp. 183–190, 1999
  51. Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications?
    Diabetes Research and Clinical Practice, vol. 45, no. 2-3, pp. 169–182, 1999
  52. The biochemical and physiological characteristics of receptors
    Advanced Drug Delivery Reviews, vol. 29, no. 3, pp. 197–213, 1998
  53. Journal of Molecular Medicine, vol. 76, no. 1, pp. 21–31, 1998
  54. Hypoxia upregulates glucose transport activity through an adenosine-mediated increase of GLUT1 expression in retinal capillary endothelial cells
    Diabetes, vol. 47, no. 9, pp. 1480–1488, 1998
  55. Protein kinase C activation and the development of diabetic complications
    Diabetes, vol. 47, no. 6, pp. 859–866, 1998
  56. A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth
    Diabetes, vol. 47, no. 7, pp. 1074–1085, 1998
  57. Cardiovascular complications of diabetes
    Diabetologia, vol. 40, no. 15, pp. B78–B82, 1997
  58. Vascular endothelial growth factor expression in canine peripheral vein bypass grafts
    Journal of Vascular Surgery, vol. 26, no. 1, pp. 79–86, 1997
  59. Targeted overexpression of protein kinase C beta 2 isoform in myocardium causes cardiomyopathy
    Proceedings of the National Academy of Sciences, vol. 94, no. 17, pp. 9320–9325, 1997
  60. THE CELLULAR AND MOLECULAR MECHANISMS OF DIABETIC COMPLICATIONS
    Endocrinology & Metabolism Clinics of North America, vol. 25, no. 2, pp. 255–270, 1996
  61. Suppression of Retinal Neovascularization in vivo by Inhibition of Vascular Endothelial Growth Factor (VEGF) Using Soluble VEGF-Receptor Chimeric Proteins
    Proceedings of the National Academy of Sciences, vol. 92, no. 23, pp. 10457–10461, 1995
  62. CELLULAR AND MOLECULAR ABNORMALITIES IN THE VASCULAR ENDOTHELIUM OF DIABETES MELLITUS
    Annual Review of Medicine, vol. 45, no. 1, pp. 179–188, 1994
  63. Identification of Multiple Genes in Bovine Retinal Pericytes Altered by Exposure to Elevated Levels of Glucose by Using mRNA Differential Display
    Proceedings of the National Academy of Sciences, vol. 91, no. 13, pp. 6231–6235, 1994
  64. Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders
    New England Journal of Medicine, vol. 331, no. 22, pp. 1480–1487, 1994
  65. Expression of a monoclonal antibody (3G5) defined ganglioside antigen in the renal cortex
    Kidney International, vol. 41, no. 6, Article ID ki1992236, 7 pages, 1992
  66. Retraction
    Biochemical and Biophysical Research Communications, vol. 180, no. 2, pp. 1164–1164, 1991
  67. Activation of Protein Kinase C by Elevation of Glucose Concentration: Proposal for a Mechanism in the Development of Diabetic Vascular Complications
    Proceedings of the National Academy of Sciences, vol. 86, no. 13, pp. 5141–5145, 1989
  68. Endothelin stimulates a sustained 1,2-diacylglycerol increase and protein kinase C activation in bovine aortic smooth muscle cells
    Biochemical and Biophysical Research Communications, vol. 162, no. 1, pp. 381–386, 1989
  69. A monoclonal antibody (3G5)-defined ganglioside antigen is expressed on the cell surface of microvascular pericytes
    Journal of Experimental Medicine, vol. 167, no. 3, pp. 1003–1015, 1988
  70. Processing and transport of insulin by vascular endothelial cells2Effects of sulfonylureas on insulin receptors
    The American Journal of Medicine, vol. 79, no. 3, pp. 43–47, 1985
  71. Sharing of Biological Effect and Receptors between Guinea Pig Insulin and Platelet-Derived Growth Factor
    Proceedings of the National Academy of Sciences, vol. 80, no. 5, pp. 1308–1312, 1983
  72. Non-parallel evolution of metabolic and growth-promoting functions of insulin
    Nature, vol. 292, no. 5824, Article ID 292644a0, 2 pages, 1981
  73. Multiplication stimulating activity (MSA) from the BRL 3A rat liver cell line: Relation to human somatomedins and insulin
    Journal of Supramolecular Structure and Cellular Biochemistry, vol. 15, no. 3, pp. 253–286, 1981