Richard Boyd

Richard Boyd is a Professor of Monash University, and Deputy Director of the new Monash Immunology and Stem Cell Laboratories (MISCL). He is also Chief Scientific Officer of UK AIM-Listed Biotechnology Company Norwood Immunology. In 2004, Richard was awarded an Australian Government Business/Higher Education Round Table (B-HERT) Award for outstanding achievement in research and development, and education and training. Richard is also the Director of the Immunology Program at the Australian Stem Cell Centre. His research has focused on the formation of the immune system and its rejuvenation following age- or chemotherapy-induced atrophy, focusing on the thymus. His laboratory has established an internationally recognised leadership position in understanding the nature and function of thymic microenvironment. Recently, their technologies have been translated into ground-breaking clinical trials on enhancing the recovery of the thymus, bone marrow, and immune function in cancer patients undergoing chemotherapy and HSCT, in Australia and the USA. He has published over 200 papers and for over 25 years has had a major role in education of undergraduate and postgraduate students at Monash University. He has also given many public lectures on immunology and stem cells, and over 500 scientific presentations at national and international conferences, and research institutes.

Biography Updated on 30 May 2007

Articles in Scholarly Journals [Incomplete List]

  1. CCR7-Dependent Cortex-to-Medulla Migration of Positively Selected Thymocytes Is Essential for Establishing Central Tolerance
    Immunity, vol. 24, no. 2, pp. 165–177, 2006
  2. Alternative explanations for T-cell response to in-situ gene therapy for prostate cancer: In reply to Fugita et al. (Int J Radiat Oncol Biol Phys 2006;65:84–90)
    International Journal of Radiation OncologyBiologyPhysics, vol. 66, no. 5, pp. 1599–1599, 2006
  3. Stemming the tide of thymic aging
    Nature Immunology, vol. 7, no. 10, Article ID ni1006-1013, 3 pages, 2006
  4. Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells
    Blood, vol. 108, no. 12, pp. 3777–3785, 2006
  5. The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells
    Development, vol. 133, no. 15, pp. 3027–3037, 2006
  6. Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice
    Diabetes, vol. 54, no. 12, pp. 3453–3457, 2005
  7. Sex Steroid Ablation Enhances Lymphoid Recovery Following Autologous Hematopoietic Stem Cell Transplantation
    Transplantation, vol. 80, no. 11, pp. 1604–1613, 2005
  8. Genetic lesions in T-cell tolerance and thresholds for autoimmunity
    Immunological Reviews, vol. 204, no. 1, pp. 87–101, 2005
  9. The alpha-toxin of Clostridium septicum is essential for virulence
    Molecular Microbiology, vol. 57, no. 5, pp. 1357–1366, 2005
  10. Controlling the thymic microenvironment
    Current Opinion in Immunology, vol. 17, no. 2, pp. 137–143, 2005
  11. Gene Dosage-limiting Role of Aire in Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity
    Journal of Experimental Medicine, vol. 200, no. 8, pp. 1015–1026, 2004
  12. CCR7 Signals Are Essential for Cortex-Medulla Migration of Developing Thymocytes
    Journal of Experimental Medicine, vol. 200, no. 4, pp. 493–505, 2004
  13. Correction
    Journal of Experimental Medicine, vol. 200, no. 7, pp. 947–948, 2004
  14. Strategies to enhance T-cell reconstitution in immunocompromised patients
    Nature Reviews Immunology, vol. 4, no. 11, Article ID nri1484, 11 pages, 2004
  15. Immunity, vol. 21, no. 6, pp. 817–830, 2004
  16. Thymic generation and regeneration
    Immunological Reviews, vol. 195, no. 1, pp. 28–50, 2003
  17. Expression of the HPV16E7 Oncoprotein by Thymic Epithelium is Accompanied by Disrupted T Cell Maturation and a Failure of the Thymus to Involute with Age
    Clinical & Developmental Immunology, vol. 10, no. 2, pp. 91–103, 2003
  18. Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells
    Nature Immunology, vol. 3, no. 7, Article ID ni812, 7 pages, 2002
  19. Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice
    Nature Immunology, vol. 3, no. 11, Article ID ni850, 6 pages, 2002
  20. One for all and all for one: thymic epithelial stem cells and regeneration
    Trends in Immunology, vol. 23, no. 8, pp. 391–395, 2002
  21. Thymic regeneration: teaching an old immune system new tricks
    Trends in Molecular Medicine, vol. 8, no. 10, pp. 469–476, 2002
  22. Role for CCR7 Ligands in the Emigration of Newly Generated T Lymphocytes from the Neonatal Thymus
    Immunity, vol. 16, no. 2, pp. 205–218, 2002
  23. Mice Lacking Glutathione Peroxidase-1 Activity Show Increased Tunel Staining and an Accelerated Inflammatory Response in Brain Following a Cold-Induced Injury
    Experimental Neurology, vol. 177, no. 1, pp. 9–20, 2002
  24. CD4+CD8+TCRlow thymocytes express low levels of glucocorticoid receptors while being sensitive to glucocorticoid-induced apoptosis
    European Journal of Immunology, vol. 31, no. 8, pp. 2293–2301, 2001
  25. Glucocorticoids and the thymus: the view from the middle of the road
    Trends in Immunology, vol. 22, no. 5, p. 243, 2001
  26. Synergistic Effects of Alpha-Toxin and Perfringolysin O in Clostridium perfringens-Mediated Gas Gangrene
    Infection and Immunity, vol. 69, no. 12, pp. 7904–7910, 2001
  27. T-cell development and function – a downunder experience
    Immunology Today, vol. 21, no. 10, pp. 472–474, 2000
  28. Stress-free T-cell development: glucocorticoids are not obligatory
    Immunology Today, vol. 21, no. 12, pp. 606–611, 2000
  29. Intrathymic T Cell Development and Selection Proceeds Normally in the Absence of Glucocorticoid Receptor Signaling
    Immunity, vol. 13, no. 2, pp. 179–186, 2000
  30. Glucocorticoid production in the murine thymus
    European Journal of Immunology, vol. 30, no. 2, pp. 337–346, 2000
  31. Construction and virulence testing of a collagenase mutant of Clostridium perfringens
    Microbial Pathogenesis, vol. 28, no. 2, pp. 107–117, 2000
  32. Development, organization and function of the thymic medulla in normal, immunodeficient or autoimmune mice
    Seminars in Immunology, vol. 11, no. 1, pp. 47–55, 1999
  33. Apoptosis and the Thymic Microenvironment in Murine Lupus
    Journal of Autoimmunity, vol. 13, no. 3, pp. 325–334, 1999
  34. Abnormal Thymic Expression of Epithelial Cell Adhesion Molecule (EP-CAM) in New Zealand Black (NZB) Mice
    Journal of Autoimmunity, vol. 13, no. 4, pp. 393–404, 1999
  35. Thymic Microenvironment and NZB Mice: The Abnormal Thymic Microenvironment of New Zealand Mice Correlates with Immunopathology
    Clinical Immunology, vol. 90, no. 3, pp. 388–398, 1999
  36. A central role for thymic emigrants in peripheral T cell homeostasis
    Proceedings of the National Academy of Sciences, vol. 96, no. 17, pp. 9787–9791, 1999
  37. The Role of the Thymus and Recent Thymic Migrants in the Maintenance of the Adult Peripheral Lymphocyte Pool
    Journal of Experimental Medicine, vol. 187, no. 11, pp. 1839–1848, 1998
  38. Mice lacking the transcription factor CIITA--a second look [In Process Citation]
    International Immunology, vol. 10, no. 12, pp. 1957–1967, 1998
  39. Positive selection of low responsive, potentially autoreactive T cells induced by high avidity, non-deleting interactions
    International Immunology, vol. 10, no. 7, pp. 999–1008, 1998
  40. Agonist peptide modulates T cell selection thresholds through qualitative and quantitative shifts in CD8 co-receptor expression
    International Immunology, vol. 9, no. 10, pp. 1527–1536, 1997
  41. The Interferon Regulatory Transcription Factor IRF-1 Controls Positive and Negative Selection of CD8+ Thymocytes
    Immunity, vol. 7, no. 2, pp. 243–254, 1997
  42. Autoantibody Production and Cytokine Profiles of MHC Class I (ß2-Microglobulin) Gene Deleted New Zealand Black (NZB) Mice
    Clinical Immunology and Immunopathology, vol. 84, no. 3, pp. 318–327, 1997
  43. Analysis of the Initiation Period of Spontaneous Autoimmune Thyroiditis (SAT) in Obese Strain (OS) of Chickens
    Journal of Autoimmunity, vol. 9, no. 2, pp. 129–138, 1996
  44. Characterization of the AKR thymic microenvironment and its influence on thymocyte differentiation and lymphoma development
    Leukemia Research, vol. 20, no. 10, pp. 853–866, 1996
  45. A bursal stromal derived cytokine induces proliferation of mhc class II bearing cells
    Developmental & Comparative Immunology, vol. 20, no. 1, pp. 61–75, 1996
  46. In vitro characterization of a novel avian haemopoietic growth factor derived from stromal cells
    Developmental & Comparative Immunology, vol. 20, no. 2, pp. 139–156, 1996
  47. The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors
    Proceedings of the National Academy of Sciences, vol. 93, no. 12, pp. 5742–5746, 1996
  48. Thymic Microenvironmental Abnormalities in MRL/MP-lpr/lpr, BXSB/MpJYaaand C3H HeJ-gld/gldMice
    Journal of Autoimmunity, vol. 8, no. 2, pp. 145–161, 1995
  49. Thymic Epithelial Cell Abnormalities in (NZB × H-2u)F1 Mice
    Clinical Immunology and Immunopathology, vol. 76, no. 3, pp. 297–307, 1995
  50. Evidence for a selective and multi-step model of T cell differentiation: CD4+CD8low thymocytes selected by a transgenic T cell receptor on major histocompatibility complex class I molecules
    European Journal of Immunology, vol. 24, no. 9, pp. 1982–1987, 1994
  51. The thymic microenvironment
    Immunology Today, vol. 14, no. 9, pp. 445–459, 1993
  52. Development in the thymus: it takes two to tango
    Immunology Today, vol. 14, no. 9, pp. 462–469, 1993
  53. Towards an integrated view of thymopoiesis
    Immunology Today, vol. 12, no. 2, pp. 71–79, 1991
  54. Characterization of immature CD4+CD8-CD3- thymocytes
    European Journal of Immunology, vol. 21, no. 3, pp. 835–838, 1991
  55. CD4+CD8+CD3high thymocytes appear transiently during ontogeny: evidence from phenotypic and functional studies
    European Journal of Immunology, vol. 21, no. 11, pp. 2655–2660, 1991
  56. Identification of t cells in early dermal lymphocytic infiltrates in avian scleroderma
    Arthritis & Rheumatism, vol. 32, no. 8, pp. 1031–1040, 1989
  57. Nature of the thymocytes associated with dendritic cells and macrophages in thymic rosettes
    Cellular Immunology, vol. 119, no. 1, pp. 85–100, 1989
  58. The murine thymic nurse cell: An isolated thymic microenvironment
    European Journal of Immunology, vol. 15, no. 1, pp. 36–42, 1985
  59. The limited immunocompetence of thymocytes within murine thymic nurse cells
    European Journal of Immunology, vol. 15, no. 10, pp. 1043–1048, 1985
  60. Ontogeny of surface markers on functionally distinct T cell subsets in the chicken
    European Journal of Immunology, vol. 14, no. 1, pp. 61–67, 1984
  61. MHC- and non-MHC-encoded surface antigens of chicken lymphoid cells and erythrocytes recognized by polyclonal xeno-, allo- and monoclonal antibodies
    European Journal of Immunology, vol. 14, no. 9, pp. 831–839, 1984
  62. Lymphoid antigenic determinants of the chicken: Ontogeny of bursa-dependent lymphoid tissue
    Developmental & Comparative Immunology, vol. 8, no. 1, pp. 149–167, 1984
  63. The B-L (Ia-like) antigens of the chicken. lymphocyte plasma membrane distribution and tissue localization
    Developmental & Comparative Immunology, vol. 8, no. 3, pp. 673–682, 1984
  64. Functional Analysis of B-L (Ia-Like) Antigen-Bearing Chicken Peripheral Blood Cells
    Scandinavian Journal of Immunology, vol. 20, no. 1, pp. 15–19, 1984
  65. Chicken thrombocytes. Isolation, serological and functional characterisation using the fluorescence activated cell sorter
    Developmental & Comparative Immunology, vol. 7, no. 1, pp. 111–125, 1983
  66. IgG-Fc and C3 receptors in the chicken: distribution, tissue localization and functional significance
    Molecular Immunology, vol. 19, no. 10, pp. 1267–1273, 1982
  67. Chicken Major Histocompatibility Complex and Disease
    Scandinavian Journal of Immunology, vol. 14, no. 6, pp. 607–616, 1981
  68. Killer cells in the chicken: A microcytotoxicity assay using antigen-coated erythrocytes as targets
    Journal of Immunological Methods, vol. 35, no. 3-4, pp. 233–247, 1980