J. Justin Hsuan

J. Justin Hsuan is the Director of the Centre for Molecular Cell Biology, Executive Director of the Royal Free Centre for Biomedical Science, and Professor of Molecular Cell Biology in the Department of Medicine at University College London. Dr. Hsuan is an internationally known researcher in lipid and protein signal transduction, primarily in the field of phosphoinositide (PI) signalling. He has contributed to the purification, cloning, and functional characterization of all the major human PI kinases. His work in the field of lipid biology has helped develop new directions of investigation into the existence and function of lipid microdomains, and the role of phosphoinositides in receptor signalling and vesicle trafficking. Dr. Hsuan completed his undergraduate and postgraduate studies at the University of Bristol. In 1986 he moved to the Ludwig Institute for Cancer Research in London, taking up a postdoctoral fellowship with Professor Mike Waterfield before running his own group for the next ten years, as well as holding a faculty position in the Department of Biochemistry and Molecular Biology at University College London. In 1999, Dr. Hsuan joined the Department of Medicine at University College London as Director of the new Centre for Molecular Cell Biology, and later that year he was awarded a Senior Fellowship by The Wellcome Trust. In 2004 Dr. Hsuan founded the Royal Free Centre for Biomedical Science to enhance translational research by university and hospital investigators. His work now focuses on the clinical importance of PI signalling and on proteomic studies of human disease.

Biography Updated on 6 February 2008

Personal Home Page

http://www.ucl.ac.uk/medicine/mcb/staff/jh.html

Articles in Scholarly Journals [Incomplete List]

  1. RdgB beta
    AfCS-Nature Molecule Pages, Article ID A003867.01, 2007
  2. Lipid and Peptide Control of Phosphatidylinositol 4-Kinase II  Activity on Golgi-endosomal Rafts
    Journal of Biological Chemistry, vol. 281, no. 7, pp. 3757–3763, 2006
  3. Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor
    Journal of Cell Science, vol. 119, no. 3, pp. 571–581, 2006
  4. Localization of a highly active pool of type II phosphatidylinositol 4-kinase in a p97/valosin-containing-protein-rich fraction of the endoplasmic reticulum
    Biochemical Journal, vol. 373, no. 1, p. 57, 2003
  5. Identification and characterization of differentially active pools of type IIa phosphatidylinositol 4-kinase activity in unstimulated A431 cells
    Biochemical Journal, vol. 376, no. 2, p. 497, 2003
  6. EGF receptors as transcription factors: ridiculous or sublime?
    Nature Cell Biology, vol. 3, no. 9, Article ID ncb0901-e209, 2001
  7. Cloning of a Human Type II Phosphatidylinositol 4-Kinase Reveals a Novel Lipid Kinase Family
    Journal of Biological Chemistry, vol. 276, no. 20, pp. 16635–16640, 2001
  8. Genome Biology, vol. 2, no. 9, p. reviews3011.1, 2001
  9. unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA
    Genes & Development, vol. 13, no. 4, pp. 437–448, 1999
  10. Cloning and Characterization of a Novel Human Phosphatidylinositol Transfer Protein, rdgBbeta
    Journal of Biological Chemistry, vol. 274, no. 44, pp. 31553–31558, 1999
  11. Epidermal growth factor receptor activation is localized within low-buoyant density, non-caveolar membrane domains
    Biochemical Journal, vol. 337, no. 3, p. 591, 1999
  12. Phosphatidylinositol 4-Phosphate Synthesis in Immunoisolated Caveolae-like Vesicles and Low Buoyant Density Non-caveolar Membranes
    Journal of Biological Chemistry, vol. 273, no. 27, pp. 17115–17121, 1998
  13. The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family
    European Journal of Immunology, vol. 28, no. 12, pp. 4071–4083, 1998
  14. Growth factor-dependent phosphoinositide signalling
    The International Journal of Biochemistry & Cell Biology, vol. 29, no. 3, pp. 415–435, 1997
  15. Synaptojanin Is the Major Constitutively Active Phosphatidylinositol-3,4,5-trisphosphate 5-Phosphatase in Rodent Brain
    Journal of Biological Chemistry, vol. 272, no. 15, pp. 9625–9628, 1997
  16. The yeast and mammalian isoforms of phosphatidylinositol transfer protein can all restore phospholipase C-mediated inositol lipid signaling in cytosol-depleted RBL-2H3 and HL-60 cells
    Proceedings of the National Academy of Sciences, vol. 93, no. 13, pp. 6589–6593, 1996
  17. Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain
    Proceedings of the National Academy of Sciences, vol. 93, no. 18, pp. 9460–9464, 1996
  18. Cloning and Expression of Human G/T Mismatch-specific Thymine-DNA Glycosylase
    Journal of Biological Chemistry, vol. 271, no. 22, pp. 12767–12774, 1996
  19. Identification of Regions of the Wiskott-Aldrich Syndrome Protein Responsible for Association with Selected Src Homology 3Domains
    Journal of Biological Chemistry, vol. 271, no. 42, pp. 26291–26295, 1996
  20. Interaction of Shc with Adaptor Protein Adaptins
    Journal of Biological Chemistry, vol. 271, no. 9, pp. 5265–5269, 1996
  21. The Friedreich's ataxia gene encodes a novel phosphatidylinositol–4–phosphate 5–kinase
    Nature Genetics, vol. 14, no. 2, Article ID ng1096-157, 5 pages, 1996
  22. MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2
    Current Biology, vol. 6, no. 4, pp. 484–486, 1996
  23. ARF and PITP restore GTP?S-stimulated protein secretion from cytosol-depleted HL60 cells by promoting PIP2 synthesis
    Current Biology, vol. 6, no. 6, pp. 730–738, 1996
  24. Involvement of Cyclophilin D in the Activation of A mitochondrial Pore by Ca2+ and Oxidant Stress
    European Journal of Biochemistry, vol. 238, no. 1, pp. 166–172, 1996
  25. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells
    Science, vol. 268, no. 5219, pp. 1909–1912, 1995
  26. GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
    Science, vol. 268, no. 5219, pp. 1912–1914, 1995
  27. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
    Science, vol. 269, no. 5224, pp. 690–693, 1995
  28. Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling
    Science, vol. 268, no. 5214, pp. 1188–1190, 1995
  29. Identification of a specific lns(l,3,4,5)P4-binding protein as a member of the GAP1 family
    Nature, vol. 376, no. 6540, Article ID 376527a0, 3 pages, 1995
  30. Mismatch repair and cancer
    Nature, vol. 367, no. 6462, Article ID 367417a0, 1 pages, 1994
  31. A target for Src in mitosis
    Nature, vol. 368, no. 6474, Article ID 368871a0, 3 pages, 1994
  32. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27
    Cell, vol. 78, no. 6, pp. 1039–1049, 1994
  33. Cloning and sequencing of cDNAs encoding the actin cross-liking protein transgelin defines a new family of actin-associated proteins
    Cell Motility and the Cytoskeleton, vol. 28, no. 3, pp. 243–255, 1994
  34. Unconventional cytotoxic T lymphocyte recognition of synthetic peptides corresponding to residues 1—23 of Ras protein
    European Journal of Immunology, vol. 24, no. 9, pp. 1988–1992, 1994
  35. Phospholipase D: a downstream effector of ARF in granulocytes
    Science, vol. 263, no. 5146, pp. 523–526, 1994
  36. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation
    Journal of Experimental Medicine, vol. 179, no. 3, pp. 881–887, 1994
  37. Purification and properties of transgelin: a transformation and shape change sensitive actin-gelling protein
    The Journal of Cell Biology, vol. 121, no. 5, pp. 1065–1073, 1993
  38. An essential role for phosphatidylinositol transfer protein in phospholipase C-Mediated inositol lipid signaling
    Cell, vol. 74, no. 5, pp. 919–928, 1993
  39. The GTPase dynamin binds to and is activated by a subset of SH3 domains
    Cell, vol. 75, no. 1, pp. 25–36, 1993
  40. A new component of the transcription factor DRTF1/E2F
    Nature, vol. 362, no. 6415, Article ID 362083a0, 4 pages, 1993
  41. Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system
    Nature, vol. 362, no. 6418, Article ID 362312a0, 6 pages, 1993
  42. Human lysozyme gene mutations cause hereditary systemic amyloidosis
    Nature, vol. 362, no. 6420, Article ID 362553a0, 4 pages, 1993
  43. Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit
    Cell, vol. 70, no. 3, pp. 419–429, 1992
  44. Apolipoprotein AI Mutation Arg-60 Causes Autosomal Dominant Amyloidosis
    Proceedings of the National Academy of Sciences, vol. 89, no. 16, pp. 7389–7393, 1992
  45. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase
    Cell, vol. 65, no. 1, pp. 91–104, 1991
  46. Bcr encodes a GTPase-activating protein for p21rac
    Nature, vol. 351, no. 6325, Article ID 351400a0, 2 pages, 1991
  47. Structural basis for epidermal growth factor receptor function
    Progress in Growth Factor Research, vol. 1, no. 1, pp. 23–32, 1989
  48. Loss of three major auto phosphorylation sites in the EGF receptor does not block the mitogenic action of EGF
    Journal of Cellular Physiology, vol. 134, no. 3, pp. 421–428, 1988