Wayne Carver received a Ph.D. in biology from the University of South Carolina, Columbia, SC, USA, in 1988. Currently, he serves as a Professor at the Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA. The research of his laboratory is focused on the molecular and cellular basis of cardiovascular disease. In particular, he seeks to understand how changes in the organization, composition, and accumulation of myocardial extracellular matrix contribute to cardiovascular disease. Many cardiovascular diseases are accompanied by alterations in the extracellular matrix, which deleteriously impact heart function. The extracellular matrix of the heart is produced primarily by interstitial fibroblasts. Enhanced accumulation of extracellular matrix or fibrosis appears to be associated with the activation of relatively quiescent fibroblasts to a contractile, secretory phenotype termed the myofibroblasts. Carver's lab utilizes in vitro and in vivo models to elucidate the underlying mechanisms that transformation to the myofibroblast phenotype. These approaches allow us to understand how biochemical and mechanical stimuli are integrated by fibroblasts and how these regulate fibroblast activity and gene expression. His areas of expertise include extracellular matrix, integrins, mechanotransduction, differentiation, and fibrosis.
Biography Updated on 31 December 2012