H. Heng
Henry Heng is an Associate Professor for the Center for Molecular Medicine and Genetics of the Wayne State University Medical School. He is also an Associate Professor for the Karmanos Cancer Institute. His research has been focused on applying a genome-based system approach to evaluate the structure and function of genomes and their variations/abnormalities to determine the biological and clinical implications. By establishing the importance of nonclonal chromosomal aberrations (NCCAs), he has demonstrated that genomic instability mediated stochastic genome aberrations are the key driving force in cancer progression and genome variations play a dominant role in system instability and evolution. By applying this concept, his group has hypothesized that sexual reproduction promotes the continuation of a species by maintaining the chromosome defined framework of a species and that the main result of sexual reproduction is the preservation of the identity of a given genome. In addition to discovering a number of new forms of chromosome aberrations such as defective mitotic figures (DMFs) and chromosome fragmentation, his group has analyzed both meiotic and mitotic chromatin loops to illustrate novel features of the chromatin loop domain and genome architecture. His group is also well known for their seminal contributions of a number of visualization technologies including pioneering high resolution fiber FISH, multiple-color DNA-protein in situ codetection, and small-sized probe FISH detection on DAPI banded chromosomes. He has authored and coauthored over 150 publications and he currently serves on the editorial board of four international journals.
Biography Updated on 9 October 2007
Personal Home Page
http://cmmg.biosci.wayne.edu/faculty/heng/index.php
Articles in Scholarly Journals [Incomplete List]
- Cancer genome sequencing: The challenges ahead
BioEssays, vol. 29, no. 8, pp. 783–794, 2007 - Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts
International Journal of Cancer, vol. 120, no. 10, pp. 2127–2134, 2007 - Elimination of altered karyotypes by sexual reproduction preserves species identity
Genome, vol. 50, no. 5, pp. 517–524, 2007 - Mitotic Cell Death by Chromosome Fragmentation
Cancer Research, vol. 67, no. 16, pp. 7686–7694, 2007 - Clonal and non-clonal chromosome aberrations and genome variation and aberration
Genome, vol. 49, no. 3, pp. 195–204, 2006 - Combined multicolor-FISH and immunostaining
Cytogenetic and Genome Research, vol. 114, no. 3-4, pp. 227–234, 2006 - Stochastic cancer progression driven by non-clonal chromosome aberrations
Journal of Cellular Physiology, vol. 208, no. 2, pp. 461–472, 2006 - Heterogeneous Duplications in Patients with Pelizaeus-Merzbacher Disease Suggest a Mechanism of Coupled Homologous and Nonhomologous Recombination
The American Journal of Human Genetics, vol. 77, no. 6, pp. 966–987, 2005 - ATM and p21 Cooperate to Suppress Aneuploidy and Subsequent Tumor Development
Cancer Research, vol. 65, no. 19, pp. 8747–8753, 2005 - Overexpression of Cyclin D1 Promotes Tumor Cell Growth and Confers Resistance to Cisplatin-Mediated Apoptosis in an Elastase-myc Transgene-Expressing Pancreatic Tumor Cell Line
Clinical Cancer Research, vol. 11, no. 16, pp. 6075–6086, 2005 - Sequential Molecular and Cellular Events during Neoplastic Progression: A Mouse Syngeneic Ovarian Cancer Model
Neoplasia, vol. 7, no. 10, pp. 944–956, 2005 - Imaging genome abnormalities in cancer research
Cell & Chromosome, vol. 3, no. 1, p. 1, 2004 - Chromatin loops are selectively anchored using scaffold/matrix-attachment regions
Journal of Cell Science, vol. 117, no. 7, pp. 999–1008, 2004 - Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the Nrf3 Locus
Molecular and Cellular Biology, vol. 24, no. 8, pp. 3286–3294, 2004 - Male mouse meiotic chromosome cores deficient in structural proteins SYCP3 and SYCP2 align by homology but fail to synapse and have possible impaired specificity of chromatin loop attachment
Cytogenetic and Genome Research, vol. 105, no. 2-4, pp. 182–188, 2004 - SV40 T antigen interacts with Nbs1 to disrupt DNA replication control
Genes & Development, vol. 18, no. 11, pp. 1305–1316, 2004 - Corrigendum to “The hyaluronidase gene HYAL1 maps to chromosome 3p21.2–p21.3 in human and 9F1–F2 in mouse, a conserved candidate tumor suppressor locus” [Genomics 48 (1998) 63–70]
Genomics, vol. 84, no. 1, p. 227, 2004 - From DNA structure to gene expression: mediators of nuclear compartmentalization and dynamics
Chromosome Research, vol. 11, no. 5, pp. 435–445, 2003 - Analysis of marker or complex chromosomal rearrangements present in pre- and post-natal karyotypes utilizing a combination of G-banding, spectral karyotyping and fluorescence in situ hybridization
Clinical Genetics, vol. 63, no. 5, pp. 358–367, 2003 - Human Chromosome 7: DNA Sequence and Biology
Science, vol. 300, no. 5620, pp. 767–772, 2003 - Alternative promoters and polyadenylation regulate tissue-specific expression ofHemogen isoforms during hematopoiesis and spermatogenesis
Developmental Dynamics, vol. 228, no. 4, pp. 606–616, 2003 - Circling, Deafness, and Yellow Coat Displayed by Yellow Submarine (Ysb) and Light Coat and Circling (Lcc) Mice with Mutations on Chromosome 3
Genomics, vol. 79, no. 6, pp. 777–784, 2002 - Sperm nuclear matrix association of the PRM1->PRM2->TNP2 domain is independent of Alu methylation
Molecular Human Reproduction, vol. 7, no. 10, pp. 903–911, 2001 - Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells
Biochemical Pharmacology, vol. 61, no. 6, pp. 665–675, 2001 - Spectral karyotyping (SKY) of mouse meiotic chromosomes
Genome, vol. 44, no. 2, pp. 293–298, 2001 - Re-defining the chromatin loop domain
Cytogenetic and Genome Research, vol. 93, no. 3-4, pp. 155–161, 2001 - The combination of SKY and specific loci detection with FISH or immunostaining
Cytogenetic and Genome Research, vol. 93, no. 3-4, pp. 195–202, 2001 - Spectral karyotyping of mouse cell line WMP2
Cytogenetic and Genome Research, vol. 90, no. 3-4, pp. 271–274, 2000 - Cloning and characterization of additional members of the G protein-coupled receptor family
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 1490, no. 3, pp. 311–323, 2000 - Identification of the mouse β`-COP golgi component as a spermatocyte autoantigen in scleroderma and mapping of its gene Copb2 to mouse Chromosome 9
Cytogenetic and Genome Research, vol. 87, no. 3-4, pp. 201–204, 1999 - Identification of a Human Histone Acetyltransferase Related to Monocytic Leukemia Zinc Finger Protein
Journal of Biological Chemistry, vol. 274, no. 40, pp. 28528–28536, 1999 - Identification and cloning of three novel human G protein-coupled receptor genes GPR52, ?GPR53 and GPR55: GPR55 is extensively expressed in human brain
Molecular Brain Research, vol. 64, no. 2, pp. 193–198, 1999 - Nontargeted Stable Integration of Recombinant Adeno-Associated Virus into Human Leukemia and Lymphoma Cell Lines as Evaluated by Fluorescence in Situ Hybridization
Human Gene Therapy, vol. 10, no. 4, pp. 537–543, 1999 - Discovery of Three Novel Orphan G-Protein-Coupled Receptors
Genomics, vol. 56, no. 1, pp. 12–21, 1999 - Cloning and Expression Analysis of a Novel WD Repeat Gene, WDR3, Mapping to 1p12–p13
Genomics, vol. 59, no. 1, pp. 85–89, 1999 - The Hyaluronidase Gene HYAL1 Maps to Chromosome 3p21.2–p21.3 in Human and 9F1–F2 in Mouse, a Conserved Candidate Tumor Suppressor Locus,
Genomics, vol. 48, no. 1, pp. 63–70, 1998 - Discovery of Three Novel G-Protein-Coupled Receptor Genes
Genomics, vol. 47, no. 2, pp. 310–313, 1998 - Mapping of the HumanHPRP3andHPRP4Genes Encoding U4/U6-Associated Splicing Factors to Chromosomes 1q21.1 and 9q31–q33,
Genomics, vol. 48, no. 2, pp. 273–275, 1998 - Cloning Genes Encoding Receptors Related to Chemoattractant Receptors
Genomics, vol. 50, no. 2, pp. 281–286, 1998 - Aquarius, a novel gene isolated by gene trapping with an RNA-dependent RNA polymerase motif
Developmental Dynamics, vol. 212, no. 2, pp. 304–317, 1998 - Chromosomal mapping and expression of the human B120 gene
Gene, vol. 213, no. 1-2, pp. 189–193, 1998 - Assignment of the Gene Encoding the Limbic System-Associated Membrane Protein (LAMP) to Mouse Chromosome 16B5 and Human Chromosome 3q13.2–q21?
Genomics, vol. 49, no. 3, pp. 472–474, 1998 - Structure and mapping of the human ß-defensin HBD-2 gene and its expression at sites of inflammation
Gene, vol. 222, no. 2, pp. 237–244, 1998 - Assignment of Mouse Fibroblast Growth Factor 10 (Fgf10) Gene to the Telomeric Region of Chromosome 13
Genomics, vol. 53, no. 2, pp. 247–248, 1998 - Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria
Proceedings of the National Academy of Sciences, vol. 95, no. 6, pp. 3059–3064, 1998 - High resolution free chromatin/DNA fiber fluorescent in situ hybridization
Journal of Chromatography A, vol. 806, no. 1, pp. 219–229, 1998 - Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis
Mechanisms of Development, vol. 78, no. 1-2, pp. 81–84, 1998 - Rad51 immunocytology in rat and mouse spermatocytes and oocytes
Chromosoma, vol. 106, no. 4, pp. 207–215, 1997 - Cloning of a DSS1 pseudogene (DSS1P1) and mapping to human Chromosome band 5q14
Mammalian Genome, vol. 8, no. 2, pp. 159–160, 1997 - Fish technology in chromosome and genome research
BioEssays, vol. 19, no. 1, pp. 75–84, 1997 - The Human ß-Defensin-1 and a-Defensins Are Encoded by Adjacent Genes: Two Peptide Families with Differing Disulfide Topology Share a Common Ancestry,
Genomics, vol. 43, no. 3, pp. 316–320, 1997 - Assignment of the Human dUTPase Gene (DUT) to Chromosome 15q15–q21.1 by Fluorescencein SituHybridization
Genomics, vol. 40, no. 1, pp. 213–215, 1997 - Expression Analysis and Chromosomal Assignment of the HumanSFRS5/SRp40Gene
Genomics, vol. 43, no. 2, pp. 165–170, 1997 - Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes
Gene, vol. 187, no. 1, pp. 75–81, 1997 - Genomic Organization and Functional Analysis of the Murine Protein Phosphatase 1c ? (Ppp1cc) Gene
Genomics, vol. 45, no. 1, pp. 211–215, 1997 - Discovery of a Novel Human G Protein-Coupled Receptor Gene (GPR25) Located on Chromosome 1
Biochemical and Biophysical Research Communications, vol. 230, no. 1, pp. 69–72, 1997 - PMS2-Related Genes Flank the Rearrangement Breakpoints Associated with Williams Syndrome and Other Diseases on Human Chromosome 7
Genomics, vol. 45, no. 2, pp. 402–406, 1997 - Amplification of CFTR Exon 9 Sequences to Multiple Locations in the Human Genome
Genomics, vol. 45, no. 3, pp. 554–561, 1997 - Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome
Human Molecular Genetics, vol. 6, no. 12, pp. 2117–2126, 1997 - Regulation of meiotic chromatin loop size by chromosomal position
Proceedings of the National Academy of Sciences, vol. 93, no. 7, pp. 2795–2800, 1996 - Localization of a novel zinc finger gene to the human chromosome 7p11.2-p12 by fluorescencein situ hybridization
Somatic Cell and Molecular Genetics, vol. 22, no. 3, pp. 237–239, 1996 - Localization of a novel zinc finger gene to human chromosome 7q22 region by fluorescencein situ hybridization
Somatic Cell and Molecular Genetics, vol. 22, no. 3, pp. 233–235, 1996 - Direct detection of expanded trinucleotide repeats using PCR and DNA hybridization techniques
American Journal of Medical Genetics, vol. 67, no. 1, pp. 85–91, 1996 - The Genes for the a and ß Subunits of the Mitochondrial Trifunctional Protein Are Both Located in the Same Region of Human Chromosome 2p23
Genomics, vol. 37, no. 1, pp. 141–143, 1996 - Localization of three novel zinc finger genes to the centromeric region of human chromosome 10 by fluorescencein situ hybridization
Somatic Cell and Molecular Genetics, vol. 22, no. 3, pp. 241–244, 1996 - Localization of Two Metabotropic Glutamate Receptor Genes,GRM3andGRM8, to Human Chromosome 7q
Genomics, vol. 31, no. 2, pp. 230–233, 1996 - Tissue Distribution, Genomic Structure, and Chromosome Mapping of Mouse and Human Eukaryotic Initiation Factor 4E-Binding Proteins 1 and 2
Genomics, vol. 38, no. 3, pp. 353–363, 1996 - Physical Mapping of Receptor Type Protein Tyrosine Phosphatase Sigma (PTPRS) to Human Chromosome 19p13.3
Genomics, vol. 38, no. 1, pp. 76–78, 1996 - Identification of Genes from a 500-kb Region at 7q11.23 That Is Commonly Deleted in Williams Syndrome Patients
Genomics, vol. 36, no. 2, pp. 328–336, 1996 - A Novel Human Gene Encoding a G-Protein-Coupled Receptor (GPR15) Is Located on Chromosome 3
Genomics, vol. 32, no. 3, pp. 462–465, 1996 - Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly
Nature Genetics, vol. 14, no. 3, Article ID ng1196-353, 3 pages, 1996 - Identification of a locus of zinc finger genes in human chromosome 19q13.1-q13.3 region by fluorescencein situ hybridization
Somatic Cell and Molecular Genetics, vol. 22, no. 3, pp. 245–248, 1996 - A novel family of repeat sequences in the mouse genome responsive to retinoic acid
Mammalian Genome, vol. 7, no. 10, pp. 741–748, 1996 - Chromosomal mapping of the second human CD8B gene locus
Immunogenetics, vol. 43, no. 4, pp. 220–226, 1996 - A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain
FEBS Letters, vol. 394, no. 3, pp. 325–329, 1996 - Characterization of a human gene related to genes encoding somatostatin receptors
FEBS Letters, vol. 398, no. 2-3, pp. 253–258, 1996 - Genomic Organization and FISH Mapping of Human Pmel 17, the Putative Silver Locus
Pigment Cell Research, vol. 9, no. 1, pp. 42–48, 1996 - Sequence Analysis and Chromosomal Localization of Human Cap Z
Journal of Biological Chemistry, vol. 270, no. 37, pp. 21472–21479, 1995 - Cloning, Expression, and Chromosomal Localization of the Human Uridine Nucleotide Receptor Gene
Journal of Biological Chemistry, vol. 270, no. 52, pp. 30845–30848, 1995 - Assignment of the Human GABA Transporter Gene (GABATHG) Locus to Chromosome 3p24-p25
Genomics, vol. 29, no. 1, pp. 302–304, 1995 - Cloning and Chromosomal Mapping of Three Novel Genes, GPR9, GPR10, and GPR14, Encoding Receptors Related to Interleukin 8, Neuropeptide Y, and Somatostatin Receptors
Genomics, vol. 29, no. 2, pp. 335–344, 1995 - Mapping of a Human LIM Protein (CLP) to Human Chromosome 11p15.1 by Fluorescence in Situ Hybridization
Genomics, vol. 28, no. 3, pp. 602–603, 1995 - Structure of the Murine MPTP-PEST Gene: Genomic Organization and Chromosomal Mapping
Genomics, vol. 28, no. 3, pp. 501–507, 1995 - The Cloning and Chromosomal Mapping of Two Novel Human Opioid-Somatostatin-like Receptor Genes, GPR7 and GPR8, Expressed in Discrete Areas of the Brain
Genomics, vol. 28, no. 1, pp. 84–91, 1995 - Assignment of the human homolog of mouse Dlx3 to Chromosome 17q21.3-q22 by analysis of somatic cell hybrids and fluorescence in situ hybridization
Mammalian Genome, vol. 6, no. 4, pp. 310–311, 1995 - Regional Localization of 725 Human Chromosome 7-Specific Yeast Artificial Chromosome Clones
Genomics, vol. 22, no. 2, pp. 439–448, 1994 - Cloning of Human Genes Encoding Novel G Protein-Coupled Receptors
Genomics, vol. 23, no. 3, pp. 609–618, 1994 - Localization of the Human Gene for Inducible Nitric Oxide Synthase (NOS2) to Chromosome 17q11.2-q12
Genomics, vol. 19, no. 1, pp. 183–185, 1994 - Organization of heterologous DNA inserts on the mouse meiotic chromosome core
Chromosoma, vol. 103, no. 6, pp. 401–407, 1994 - The murine Xe169 gene escapes X–inactivation like its human homologue
Nature Genetics, vol. 7, no. 4, Article ID ng0894-491, 5 pages, 1994 - Isolation of P1 bacteriophage clones containing large contiguous segments of the human and mouse loci for the T-cell coreceptor molecule CD8
Genetic Analysis: Biomolecular Engineering, vol. 11, no. 5-6, pp. 129–139, 1994 - A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11
Gene, vol. 136, no. 1-2, pp. 355–360, 1993 - Modes of DAPI banding and simultaneous in situ hybridization
Chromosoma, vol. 102, no. 5, pp. 325–332, 1993 - Chromosomal Localization of the Human Gene Encoding the 51-kDa Subunit of Mitochondrial Complex I (NDUFV1) to 11q13
Genomics, vol. 18, no. 2, pp. 435–439, 1993 - Refined Mapping of the GM2 Activator Protein (GM2A) Locus to 5q31.3-q33.1, Distal to the Spinal Muscular Atrophy Locus
Genomics, vol. 18, no. 2, pp. 429–431, 1993 - High-Resolution Mapping of Mammalian Genes by In situ Hybridization to Free Chromatin
Proceedings of the National Academy of Sciences, vol. 89, no. 20, pp. 9509–9513, 1992