Henry Heng is an Associate Professor for the Center for Molecular Medicine and Genetics of the Wayne State University Medical School. He is also an Associate Professor for the Karmanos Cancer Institute. His research has been focused on applying a genome-based system approach to evaluate the structure and function of genomes and their variations/abnormalities to determine the biological and clinical implications. By establishing the importance of nonclonal chromosomal aberrations (NCCAs), he has demonstrated that genomic instability mediated stochastic genome aberrations are the key driving force in cancer progression and genome variations play a dominant role in system instability and evolution. By applying this concept, his group has hypothesized that sexual reproduction promotes the continuation of a species by maintaining the chromosome defined framework of a species and that the main result of sexual reproduction is the preservation of the identity of a given genome. In addition to discovering a number of new forms of chromosome aberrations such as defective mitotic figures (DMFs) and chromosome fragmentation, his group has analyzed both meiotic and mitotic chromatin loops to illustrate novel features of the chromatin loop domain and genome architecture. His group is also well known for their seminal contributions of a number of visualization technologies including pioneering high resolution fiber FISH, multiple-color DNA-protein in situ codetection, and small-sized probe FISH detection on DAPI banded chromosomes. He has authored and coauthored over 150 publications and he currently serves on the editorial board of four international journals.
Biography Updated on 16 October 2007