Wiep Scheper obtained an M.S. degree in medical biology and a Ph.D. degree in molecular biology from Utrecht University, Utrecht, The Netherlands. Her interest in neurodegenerative disorders started during a Postdoc on the molecular biology of Alzheimer's disease (AD) at the Academic Medical Center, Amsterdam, The Netherlands. Protein trafficking and quality control became central themes in the research line, consolidated during a 2-year-Postdoc in Cambridge, UK, focusing on the endoplasmic reticulum (ER). In 2007, Scheper served as a Staff at the Academic Medical Center and obtained Grants from The Netherlands Organisation for Research, International Foundation for Alzheimer Research, Dutch Brain Foundation, and the European Union. Her neurodegeneration group studies the role of endoplasmic reticulum stress and proteostasis in neurodegenerative disorders, predominantly AD. The research is focusing on early factors that drive the pathogenesis in sporadic AD, ultimately to identify a reversible phase in the disease process. A major focus of the research is the activation of the ER stress response (UPR) which her group showed is activated as an early event in AD and non-AD tauopathies. A recent research interest is the connection between metabolic syndrome and AD pathology. In the group studies, they involve both main pathological proteins in AD, Aß, and tau.
Biography Updated on 12 April 2012