Phillip B. Hylemon

Virginia Commonwealth University, USA 0000-0002-0529-1949

Phillip B. Hylemon, Ph.D. Professor of Microbiology and Medicine, Medical College (MCV) of Virginia Campus, Virginia Commonwealth University (VCU), Richmond, Virginia, USA Background: Phil received his B.S. degree in Biology and Mathematics from Barton College in 1967 and his Ph.D. degree in Microbiology and Biochemistry from Virginia Tech in 1971. He then did postdoctoral studies at MCV-VCU in the area of Microbial Biochemistry before joining the faculty in Microbiology and Immunology in 1973. Honors: Winner of the Adolf Windaus Prize for outstanding publications in the field of bile acid research,1990; Winner of Virginia’s Outstanding Scientist Award, 1991; Winner of VCU’s Award of Excellence, 2005. Member American Academy of Microbiology. Research Interest and Expertise: Phil’s research interest centers around three different areas of bile acid, cholesterol, and lipid metabolism.1) Bile acid activated cell signaling pathways and nuclear receptors in the liver and effects on glucose and lipid metabolism. The role of bile acid activated G-protein coupled receptors (GPCRs) and regulation of the ERK and ATK signaling pathways in the liver and gastrointestinal tract. 2) Metabolism of bile acids by intestinal anaerobic bacteria especially the enzymology and genetics of bile acid 7a-dehydroxylation. The role of secondary bile acids and diet in the etiology of gastrointestinal diseases including: colon cancer and cholesterol gallstone disease. 3) Effects of HIV protease inhibitors on ER stress and lipid metabolism in macrophages and hepatocytes.

Biography Updated on 22 April 2014

Scholarly Contributions [Data Provided by scopus]

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