Jan Joseph Melenhorst
Jan Joseph Melenhorst works as a translational immunologist with a primary interest in tumor immunology in the setting of allogeneic hematopoietic stem cell transplantation. He currently holds a Staff Scientist position at the US National Institutes of Health, National Heart, Lung, and Blood Institute (NIH/NHLBI). He obtained his M.S. degree in medical biology at the Nijmegen University in Nijmegen, Netherlands, and a Ph.D. degree in medicine at the Leiden University Medical Center, Leiden, Netherlands, where he examined the immune pathogenesis of the bone marrow failure syndrome aplastic anemia. In 1998, he moved to the NIH/NHLBI to join the Laboratory of Dr. John Barrett at the Hematology Branch, initially continuing his interest in investigating the immunological basis of bone marrow failure syndromes. Currently, his main interests are in the identification and characterization of leukemia-specific T cell responses, the immunobiology of graft-versus-host disease, mapping the immunomodulatory effect of mesenchymal stromal cells and leukemias on T cell and natural killer cell function. The ultimate aim of his research is to better target leukemic cells while sparing healthy cells through systemic interrogation in vitro and ex vivo of immune responses.
Biography Updated on 8 August 2010