J. Zierath

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Articles in Scholarly Journals [Incomplete List]

  1. Insulin signaling and glucose transport in insulin resistant human skeletal muscle
    Cell Biochemistry and Biophysics, vol. 48, no. 2-3, pp. 103–113, 2007
  2. Fighting the battle of the bulge: exercise training in early-onset type 2 diabetes
    Diabetologia, vol. 50, no. 7, pp. 1362–1364, 2007
  3. Effect of a novel non-thiazolidinedione peroxisome proliferator-activated receptor a/? agonist on glucose uptake
    Diabetologia, vol. 50, no. 5, pp. 1048–1057, 2007
  4. The Path to Insulin Resistance: Paved with Ceramides?
    Cell Metabolism, vol. 5, no. 3, pp. 161–163, 2007
  5. MAP4K4 Gene Silencing in Human Skeletal Muscle Prevents Tumor Necrosis Factor- -induced Insulin Resistance
    Journal of Biological Chemistry, vol. 282, no. 11, pp. 7783–7789, 2007
  6. TXNIP Regulates Peripheral Glucose Metabolism in Humans
    PLoS Medicine, vol. 4, no. 5, p. e158, 2007
  7. Skeletal muscle AMP kinase as a target to prevent pathogenesis of Type 2 diabetes
    Expert Review of Endocrinology & Metabolism, vol. 2, no. 4, pp. 477–485, 2007
  8. Interleukin-6 Directly Increases Glucose Metabolism in Resting Human Skeletal Muscle
    Diabetes, vol. 56, no. 6, pp. 1630–1637, 2007
  9. AMP-activated protein kinase signaling in metabolic regulation
    Journal of Clinical Investigation, vol. 116, no. 7, pp. 1776–1783, 2006
  10. Insulin Signaling and Glucose Transport in Skeletal Muscle From First-Degree Relatives of Type 2 Diabetic Patients
    Diabetes, vol. 55, no. 5, pp. 1283–1288, 2006
  11. Exercise-Induced Phosphorylation of the Novel Akt Substrates AS160 and Filamin A in Human Skeletal Muscle
    Diabetes, vol. 55, no. 6, pp. 1776–1782, 2006
  12. AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits
    Diabetes, vol. 55, no. 7, pp. 2051–2058, 2006
  13. Neuregulins Mediate Calcium-induced Glucose Transport during Muscle Contraction
    Journal of Biological Chemistry, vol. 281, no. 31, pp. 21690–21697, 2006
  14. Calcineurin Regulates Skeletal Muscle Metabolism via Coordinated Changes in Gene Expression
    Journal of Biological Chemistry, vol. 282, no. 3, pp. 1607–1614, 2006
  15. Opposite Transcriptional Regulation in Skeletal Muscle of AMP-activated Protein Kinase  3 R225Q Transgenic Versus Knock-out Mice
    Journal of Biological Chemistry, vol. 281, no. 11, pp. 7244–7252, 2006
  16. siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
    Cell Metabolism, vol. 4, no. 1, pp. 89–96, 2006
  17. Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes
    Diabetologia, vol. 49, no. 12, pp. 2983–2992, 2006
  18. Evidence that oestrogen receptor-a plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver
    Diabetologia, vol. 49, no. 3, pp. 588–597, 2006
  19. Specific cleavage of insulin-like growth factor-binding protein-1 by a novel protease activity
    Cellular and Molecular Life Sciences, vol. 63, no. 19-20, pp. 2405–2414, 2006
  20. Low-intensity exercise increases skeletal muscle protein expression of PPARd and UCP3 in type 2 diabetic patients
    Diabetes/Metabolism Research and Reviews, vol. 22, no. 6, pp. 492–498, 2006
  21. Fine-tuning insulin and nitric oxide signalling by turning up the AMPs: new insights into AMP-activated protein kinase signalling
    Diabetologia, vol. 48, no. 12, pp. 2451–2453, 2005
  22. Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1
    Diabetologia, vol. 48, no. 6, pp. 1173–1179, 2005
  23. Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle
    Diabetologia, vol. 48, no. 11, pp. 2354–2364, 2005
  24. Integration of mathematical and experimental approaches to resolve insulin signalling
    Acta Physiologica Scandinavica, vol. 183, no. 1, pp. 125–126, 2005
  25. 5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics
    The FASEB Journal, vol. 19, no. 7, pp. 773–779, 2005
  26. Foreword
    Acta Physiologica Scandinavica, vol. 183, no. 1, pp. 1–2, 2005
  27. Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans
    The FASEB Journal, 2005
  28. Effects of calcineurin activation on insulin-, AICAR- and contraction-induced glucose transport in skeletal muscle
    The Journal of Physiology, vol. 567, no. 2, pp. 379–386, 2005
  29. Insulin signal transduction in human skeletal muscle: identifying the defects in Type II diabetes
    Biochemical Society Transactions, vol. 33, no. 2, p. 354, 2005
  30. Role of AMP-Activated Protein Kinase in the Control of Glucose Homeostasis
    Current Molecular Medicine, vol. 5, no. 3, pp. 341–348, 2005
  31. Direct Activation of Glucose Transport in Primary Human Myotubes After Activation of Peroxisome Proliferator-Activated Receptor  
    Diabetes, vol. 54, no. 4, pp. 1157–1163, 2005
  32. Changes in Exercise-Induced Gene Expression in 5'-AMP-Activated Protein Kinase  3-Null and  3 R225Q Transgenic Mice
    Diabetes, vol. 54, no. 12, pp. 3484–3489, 2005
  33. Tumor Necrosis Factor-  Induces Skeletal Muscle Insulin Resistance in Healthy Human Subjects via Inhibition of Akt Substrate 160 Phosphorylation
    Diabetes, vol. 54, no. 10, pp. 2939–2945, 2005
  34. Effects of Metformin and Rosiglitazone Treatment on Insulin Signaling and Glucose Uptake in Patients With Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Study
    Diabetes, vol. 54, no. 5, pp. 1459–1467, 2005
  35. Expression of Mfn2, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle: Effects of Type 2 Diabetes, Obesity, Weight Loss, and the Regulatory Role of Tumor Necrosis Factor   and Interleukin-6
    Diabetes, vol. 54, no. 9, pp. 2685–2693, 2005
  36. Insulin-Stimulated Phosphorylation of the Akt Substrate AS160 Is Impaired in Skeletal Muscle of Type 2 Diabetic Subjects
    Diabetes, vol. 54, no. 6, pp. 1692–1697, 2005
  37. Effects of Insulin, Contraction, and Phorbol Esters on Mitogen-Activated Protein Kinase Signaling in Skeletal Muscle From Lean and ob/ob Mice
    Diabetes, vol. 53, no. 6, pp. 1436–1444, 2004
  38. Dissociation between Fat-Induced in Vivo Insulin Resistance and Proximal Insulin Signaling in Skeletal Muscle in Men at Risk for Type 2 Diabetes
    Journal of Clinical Endocrinology & Metabolism, vol. 89, no. 3, pp. 1301–1311, 2004
  39. Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise
    AJP: Endocrinology and Metabolism, vol. 287, no. 1, pp. E1–E7, 2004
  40. MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways
    AJP: Cell Physiology, vol. 286, no. 6, pp. C1410–C1416, 2004
  41. Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake
    AJP: Endocrinology and Metabolism, vol. 287, no. 3, pp. E553–E557, 2004
  42. Skeletal Muscle Fiber Type: Influence on Contractile and Metabolic Properties
    PLoS Biology, vol. 2, no. 10, p. e348, 2004
  43. Sending the Signal: Molecular Mechanisms Regulating Glucose Uptake
    Medicine & Science in Sports & Exercise, vol. 36, no. 7, pp. 1212–1217, 2004
  44. Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle
    Proceedings of the Nutrition Society, vol. 63, no. 2, pp. 227–232, 2004
  45. Integration of Metabolic and Mitogenic Signal Transduction in Skeletal Muscle
    Exercise and Sport Sciences Reviews, vol. 32, no. 1, pp. 4–8, 2004
  46. Insulin Signaling Defects in Type 2 Diabetes
    Reviews in Endocrine and Metabolic Disorders, vol. 5, no. 2, pp. 111–117, 2004
  47. The 5'-AMP-activated Protein Kinase  3 Isoform Has a Key Role in Carbohydrate and Lipid Metabolism in Glycolytic Skeletal Muscle
    Journal of Biological Chemistry, vol. 279, no. 37, pp. 38441–38447, 2004
  48. Analysis of Insulin Signaling Pathways through Comparative Genomics. Mapping Mechanisms for Insulin Resistance in Type 2 (Non-Insulin-Dependent) Diabetes Mellitus
    Experimental and Clinical Endocrinology & Diabetes, vol. 111, no. 4, pp. 191–197, 2003
  49. Pancreas, vol. 26, no. 2, pp. 173–177, 2003
  50. Skeletal Muscle Reprogramming by Activation of Calcineurin Improves Insulin Action on Metabolic Pathways
    Journal of Biological Chemistry, vol. 278, no. 45, pp. 44298–44304, 2003
  51. Effect of Hyperglycemia on Signal Transduction in Skeletal Muscle from Diabetic Goto-Kakizaki Rats
    Endocrinology, vol. 144, no. 12, pp. 5259–5267, 2003
  52. Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism. A NOVEL REGULATORY MECHANISM ALTERED IN OBESITY
    Journal of Biological Chemistry, vol. 278, no. 19, pp. 17190–17197, 2003
  53. Insulin signalling and resistance in patients with chronic heart failure
    The Journal of Physiology, vol. 550, no. 1, pp. 305–315, 2003
  54. Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients
    Diabetologia, vol. 46, no. 10, pp. 1324–1328, 2003
  55. Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise
    The Journal of Physiology, vol. 546, no. 2, pp. 327–335, 2003
  56. 5-Amino-Imidazole Carboxamide Riboside Increases Glucose Transport and Cell-Surface GLUT4 Content in Skeletal Muscle From Subjects With Type 2 Diabetes
    Diabetes, vol. 52, no. 5, pp. 1066–1072, 2003
  57. The effect of hyperglycaemia on glucose disposal and insulin signal transduction in skeletal muscle
    Best Practice & Research Clinical Endocrinology & Metabolism, vol. 17, no. 3, pp. 385–398, 2003
  58. Exercise-Induced Protein Kinase C Isoform-Specific Activation in Human Skeletal Muscle
    Diabetes, vol. 53, no. 1, pp. 21–24, 2003
  59. Isoform-Specific Regulation of 5' AMP-Activated Protein Kinase in Skeletal Muscle From Obese Zucker (fa/fa) Rats in Response to Contraction
    Diabetes, vol. 51, no. 9, pp. 2703–2708, 2002
  60. 5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice
    Diabetologia, vol. 45, no. 1, pp. 56–65, 2002
  61. Absence of functional insulin receptor substrate-3 ( IRS-3 ) gene in humans
    Diabetologia, vol. 45, no. 12, pp. 1697–1702, 2002
  62. Insulin signal transduction and glucose transport in human adipocytes: effects of obesity and low calorie diet
    Diabetologia, vol. 45, no. 8, pp. 1128–1135, 2002
  63. Gene expression of the p85α regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects
    Pflügers Archiv European Journal of Physiology, vol. 445, no. 1, pp. 25–31, 2002
  64. Analysis of paradoxical observations on the association between leptin and insulin resistance
    The FASEB Journal, vol. 16, no. 10, pp. 1163–1176, 2002
  65. Regulation of glucose transport in human skeletal muscle
    Annals of Medicine, vol. 34, no. 6, pp. 410–418, 2002
  66. Insulin- and Glucose-Induced Phosphorylation of the Na+,K+-Adenosine Triphosphatase  -Subunits in Rat Skeletal Muscle
    Endocrinology, vol. 142, no. 8, pp. 3474–3482, 2001
  67. Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle
    The Journal of Physiology, vol. 536, no. 1, pp. 273–282, 2001
  68. Intracellular mechanisms underlying increases in glucose uptake in response to insulin or exercise in skeletal muscle
    Acta Physiologica Scandinavica, vol. 171, no. 3, pp. 249–257, 2001
  69. Mitogen-activated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction
    Acta Physiologica Scandinavica, vol. 172, no. 3, pp. 227–238, 2001
  70. GLUT4: a key player regulating glucose homeostasis? Insights from transgenic and knockout mice
    Molecular Membrane Biology, vol. 18, no. 3, pp. 205–211, 2001
  71. Metabolic adaptations in skeletal muscle overexpressing GLUT4: effects on muscle and physical activity
    The FASEB Journal, vol. 15, no. 6, pp. 958–969, 2001
  72. 5-aminoimidazole-4-carboxy-amide-1-β-D-ribofuranoside treatment ameliorates hyperglycaemia and hyperinsulinaemia but not dyslipidaemia in KKA y -CETP mice
    Diabetologia, vol. 44, no. 12, pp. 2180–2186, 2001
  73. Insulin Signal Transduction in Skeletal Muscle From Glucose-Intolerant Relatives With Type 2 Diabetes
    Diabetes, vol. 50, no. 12, pp. 2770–2778, 2001
  74. Isomer-Specific Antidiabetic Properties of Conjugated Linoleic Acid: Improved Glucose Tolerance, Skeletal Muscle Insulin Action, and UCP-2 Gene Expression
    Diabetes, vol. 50, no. 5, pp. 1149–1157, 2001
  75. Skeletal muscle and insulin sensitivity: pathophysiological alterations
    Frontiers in Bioscience, vol. 6, no. 1, p. d154, 2001
  76. Erratum
    Diabetes, vol. 51, no. 2, pp. 552–552, 2001
  77. Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients
    Diabetes, vol. 49, no. 4, pp. 647–654, 2000
  78. Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients
    Diabetes, vol. 49, no. 2, pp. 284–292, 2000
  79. Insulin action and insulin resistance in human skeletal muscle
    Diabetologia, vol. 43, no. 7, pp. 821–835, 2000
  80. Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: Differential effects on insulin-receptor substrates 1 and 2
    Proceedings of the National Academy of Sciences, vol. 97, no. 1, pp. 38–43, 2000
  81. Effect of Contraction on Mitogen-activated Protein Kinase Signal Transduction in Skeletal Muscle. INVOLVEMENT OF THE MITOGEN- AND STRESS-ACTIVATED PROTEIN KINASE 1
    Journal of Biological Chemistry, vol. 275, no. 2, pp. 1457–1462, 2000
  82. Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats
    Human Molecular Genetics, vol. 9, no. 14, pp. 2149–2158, 2000
  83. Altered skeletal muscle glucose transport and blood lipid levels in habitual cigarette smokers
    Clinical Physiology, vol. 19, no. 2, pp. 135–142, 1999
  84. In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle
    Biochemical Journal, vol. 342, no. 2, p. 321, 1999
  85. Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice
    Science, vol. 284, no. 5416, pp. 974–977, 1999
  86. Changes in glucose transport and protein kinase Cβ 2 in rat skeletal muscle induced by hyperglycaemia
    Diabetologia, vol. 42, no. 9, pp. 1071–1079, 1999
  87. Regulation of UCP2 and UCP3 by muscle disuse and physical activity in tetraplegic subjects
    Diabetologia, vol. 42, no. 7, pp. 826–830, 1999
  88. Effect of the nicotine metabolite 5'-hydroxycotinine on glucose transport and glycogen synthase activity in rat skeletal muscle
    Pflügers Archiv European Journal of Physiology, vol. 439, no. 1-2, pp. 130–133, 1999
  89. Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats
    Diabetes, vol. 48, no. 3, pp. 664–670, 1999
  90. Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle
    Diabetes, vol. 48, no. 2, pp. 310–320, 1999
  91. Role of Skeletal Muscle in Thiazolidinedione Insulin Sensitizer (PPAR  Agonist) Action
    Endocrinology, vol. 139, no. 12, pp. 5034–5041, 1998
  92. Uncoupling protein 3 is reduced in skeletal muscle of NIDDM patients
    Diabetes, vol. 47, no. 9, pp. 1528–1531, 1998
  93. Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects
    Diabetes, vol. 47, no. 8, pp. 1281–1286, 1998
  94. Exercise in the Management of Non???Insulin-Dependent Diabetes Mellitus
    Sports Medicine, vol. 25, no. 1, pp. 25–35, 1998
  95. Regional difference in insulin inhibition of non-esterified fatty acid release from human adipocytes: relation to insulin receptor phosphorylation and intracellular signalling through the insulin receptor substrate-1 pathway
    Diabetologia, vol. 41, no. 11, pp. 1343–1354, 1998
  96. Molecular and Cellular Biochemistry, vol. 182, no. 1/2, pp. 153–160, 1998
  97. Restoration of Hypoxia-stimulated Glucose Uptake in GLUT4-deficient Muscles by Muscle-specific GLUT4 Transgenic Complementation
    Journal of Biological Chemistry, vol. 273, no. 33, pp. 20910–20915, 1998
  98. Differential Regulation of Phosphoinositide 3-Kinase Adapter Subunit Variants by Insulin in Human Skeletal Muscle
    Journal of Biological Chemistry, vol. 272, no. 30, pp. 19000–19007, 1997
  99. Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism
    Diabetologia, vol. 40, no. 10, pp. 1172–1177, 1997
  100. C-peptide stimulates glucose transport in isolated human skeletal muscle independent of insulin receptor and tyrosine kinase activation
    Diabetologia, vol. 39, no. 3, pp. 306–313, 1996
  101. Overexpression of Ha-ras Selectively in Adipose Tissue of Transgenic Mice
    Journal of Biological Chemistry, vol. 271, no. 19, pp. 11347–11355, 1996
  102. Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM
    Diabetologia, vol. 39, no. 10, pp. 1180–1189, 1996
  103. Glucose transporters and diabetes
    Seminars in Cell & Developmental Biology, vol. 7, no. 2, pp. 295–307, 1996
  104. Regulation of Human Insulin Receptor RNA Splicing in vivo
    Proceedings of the National Academy of Sciences, vol. 91, no. 4, pp. 1465–1469, 1994
  105. Effect of metformin on insulin-stimulated glucose transport in isolated skeletal muscle obtained from patients with NIDDM
    Diabetologia, vol. 37, no. 8, pp. 826–832, 1994
  106. Effects of non-esterified fatty acids on insulin-stimulated glucose transport in isolated skeletal muscle from patients with type 2 (non-insulin-dependent) diabetes mellitus
    Acta Diabetologica, vol. 31, no. 3, pp. 169–172, 1994
  107. Effects of glycaemia on glucose transport in isolated skeletal muscle from patients with NIDDM: in vitro reversal of muscular insulin resistance
    Diabetologia, vol. 37, no. 3, pp. 270–277, 1994
  108. Insulin Action on Glucose Transport in Isolated Skeletal Muscle from Patients with Liver Cirrhosis
    Scandinavian Journal of Gastroenterology, vol. 29, no. 1, pp. 71–76, 1994
  109. Exercise Training in Obese Diabetic Patients
    Sports Medicine, vol. 14, no. 3, pp. 171–189, 1992
  110. Human islet amyloid polypeptide at pharmacological levels inhibits insulin and phorbol ester-stimulated glucose transport in in vitro incubated human muscle strips
    Diabetologia, vol. 35, no. 1, pp. 26–31, 1992
  111. Insulin-like growth factor II stimulates glucose transport in human skeletal muscle
    FEBS Letters, vol. 307, no. 3, pp. 379–382, 1992
  112. The effects of exercise mode, swimming vs. running, upon bone growth in the rapidly growing female rat
    Mechanisms of Ageing and Development, vol. 66, no. 1, pp. 59–69, 1992
  113. Effect of human C-peptide on glucose transport in in vitro incubated human skeletal muscle
    Diabetologia, vol. 34, no. 12, pp. 899–901, 1991