K-Raman Purushothaman has obtained his M.D degree from Madras University and completed his postdoctoral training in pathology at Madras Medical College and Jawaharlal Nehru Institute of Postgraduate Medical Education & Research Center, India. He joined Dr. Pedro Moreno's Cardiovascular Research Laboratory as Director of histology at the University of Kentucky and involved in the histopathological evaluation of human and experimental atherosclerosis. Later, he joined Mount Sinai School of Medicine as a Full Time Faculty Assistant Professor of Medicine in cardiology/medicine. His current research focuses on histopathologic quantification of carotid, coronary, aortic, and peripheral vascular atherosclerosis. He is also involved in the study of intimal, medial, and adventitial, plaque compositional changes in the plaque progression and regression and the risk factors (diabetes mellitus, cigarette smoking, and hypercholesterolemia) involving the association of inflammation, neovascularization, and plaque rupture. He is also involved in the evaluation of histomorphological features of valvular heart diseases, myocardial infarction, and cardiomyopathy in human and experimental animal models. His animal experimental studies involve preclinical evaluation of drug eluting stents by analyzing the effects of drug eluting stents in stabilizing the vulnerable rabbit aortic plaques and study the plaque composition. His efforts will be to study the neovascularization and the implications in plaque rupture in diabetics versus nondiabetics based on the preliminary analysis in human atherosclerotic plaques and to develop an animal model to study the mechanism involved in neovascularization in atherosclerotic plaques.
Biography Updated on 20 March 2011