Nicos A. Petasis

Nicos A. Petasis received his B.S. degree in chemistry from the Aristotle University of Thessaloniki, in Greece, and his Ph.D. degree in organic chemistry from the University of Pennsylvania in Philadelphia, Pa, USA. He is currently the Harold E. & Lillian M. Moulton Professor of Chemistry at the University of Southern California, where he is also a Member of the Loker Hydrocarbon Research Institute and the Norris Comprehensive Cancer Center. His work on new methods and strategies for organic synthesis has led to several widely used chemical reactions, including the titanium-mediated carbonyl olefination, and the multicomponent reactions of organoboron compounds with amines and carbonyls. His collaborative research on polyunsaturated lipid mediators has helped elucidate the beneficial roles of omega-3 fatty acids, and led to a number of new anti-inflammatory agents. He has given over 150 invited lectures worldwide and his work led to 2 books, over 130 papers, 115 conference presentations, and 40 patents and patent applications. He has also been a scientific advisor to the pharmaceutical industry, and for 2007-2008 he is the recipient of a worldwide Chemistry Lectureship from Novartis.

Biography Updated on 31 December 2007

Personal Home Page

http://www-bcf.usc.edu/~petasis/

Articles in Scholarly Journals [Incomplete List]

  1. Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties
    Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 4, pp. 1382–1387, 2008
  2. COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro
    Molecular Cancer, vol. 7, no. 1, p. 38, 2008
  3. Aggravated Endoplasmic Reticulum Stress as a Basis for Enhanced Glioblastoma Cell Killing by Bortezomib in Combination with Celecoxib or Its Non-Coxib Analogue, 2,5-Dimethyl-Celecoxib
    Cancer Research, vol. 68, no. 3, pp. 843–851, 2008
  4. Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs
    Expert Opinion on Investigational Drugs, vol. 17, no. 2, pp. 197–208, 2008
  5. Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib
    Molecular Cancer Therapeutics, vol. 6, no. 4, pp. 1262–1275, 2007
  6. Resolvin D1 and Its Aspirin-triggered 17R Epimer: STEREOCHEMICAL ASSIGNMENTS, ANTI-INFLAMMATORY PROPERTIES, AND ENZYMATIC INACTIVATION
    Journal of Biological Chemistry, vol. 282, no. 13, pp. 9323–9334, 2007
  7. Expanding Roles for Organoboron Compounds – Versatile and Valuable Molecules for Synthetic, Biological and Medicinal Chemistry
    Australian Journal of Chemistry, vol. 60, no. 11, p. 795, 2007
  8. Simultaneous lipidomic analysis of three families of bioactive lipid mediators leukotrienes, resolvins, protectins and related hydroxy-fatty acids by liquid chromatography/electrospray ionisation tandem mass spectrometry
    Rapid Communications in Mass Spectrometry, vol. 22, no. 2, pp. 75–83, 2007
  9. Resolvin D1, Protectin D1, and Related Docosahexaenoic Acid-Derived Products: Analysis via Electrospray/Low Energy Tandem Mass Spectrometry Based on Spectra and Fragmentation Mechanisms
    Journal of the American Society for Mass Spectrometry, vol. 18, no. 1, pp. 128–144, 2007
  10. Identification of endogenous resolvin E1 and other lipid mediators derived from eicosapentaenoic acid via electrospray low-energy tandem mass spectrometry: spectra and fragmentation mechanisms
    Rapid Communications in Mass Spectrometry, vol. 21, no. 1, pp. 7–22, 2006
  11. Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury
    Journal of Experimental Medicine, vol. 203, no. 4, pp. 857–863, 2006
  12. Metabolic Inactivation of Resolvin E1 and Stabilization of Its Anti-inflammatory Actions
    Journal of Biological Chemistry, vol. 281, no. 32, pp. 22847–22854, 2006
  13. Molecular Cancer, vol. 5, no. 1, p. 19, 2006
  14. RvE1 protects from local inflammation and osteoclast-mediated bone destruction in periodontitis
    The FASEB Journal, 2005
  15. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis
    Proceedings of the National Academy of Sciences, vol. 102, no. 21, pp. 7671–7676, 2005
  16. Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib
    Blood, vol. 106, no. 13, pp. 4330–4338, 2005
  17. Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo
    British Journal of Pharmacology, vol. 146, no. 3, Article ID 0706338, 7 pages, 2005
  18. Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
    Journal of Experimental Medicine, vol. 201, no. 5, pp. 713–722, 2005
  19. Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins
    Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 73, no. 3-4, pp. 301–321, 2005
  20. Cystic fibrosis and lipoxins
    Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 73, no. 3-4, pp. 263–270, 2005
  21. Dimethyl celecoxib as a novel non–cyclooxygenase 2 therapy in the treatment of non–small cell lung cancer
    Journal of Thoracic and Cardiovascular Surgery, vol. 130, no. 5, pp. 1406–1412, 2005
  22. Organic Letters, vol. 6, no. 13, pp. 2205–2207, 2004
  23. Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway
    Nature Immunology, vol. 5, no. 4, Article ID ni1056, 4 pages, 2004
  24. Interactions Between Lipoxin A4, the Stable Analogue 16-phenoxy-lipoxin A4 and Leukotriene B4 in Cytokine Generation by Human Monocytes
    Scandinavian Journal of Immunology, vol. 60, no. 3, pp. 249–256, 2004
  25. 15-Epi-16-(Para-Fluorophenoxy)-Lipoxin A4-Methyl Ester, a Synthetic Analogue of 15-epi-Lipoxin A4, Is Protective in Experimental Ischemic Acute Renal Failure
    Journal of the American Society of Nephrology, vol. 13, no. 6, pp. 1657–1662, 2002
  26. Lipoxins, Aspirin-Triggered Epi-Lipoxins, Lipoxin Stable Analogues, and the Resolution of Inflammation: Stimulation of Macrophage Phagocytosis of Apoptotic Neutrophils In Vivo
    Journal of the American Society of Nephrology, vol. 13, no. 10, pp. 2497–2507, 2002
  27. Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes
    Proceedings of the National Academy of Sciences, vol. 99, no. 20, pp. 13266–13271, 2002
  28. The Journal of Organic Chemistry, vol. 67, no. 11, pp. 3718–3723, 2002
  29. The Journal of Organic Chemistry, vol. 67, no. 17, pp. 6286–6286, 2002
  30. One-step three-component reaction among organoboronic acids, amines and salicylaldehydes
    Tetrahedron Letters, vol. 42, no. 49, pp. 539–542, 2001
  31. Journal of Organic Chemistry, vol. 66, no. 2, pp. 633–634, 2001
  32. Synthesis of piperazinones and benzopiperazinones from 1,2-diamines and organoboronic acids
    Tetrahedron Letters, vol. 41, no. 49, pp. 9607–9611, 2000
  33. Biochemistry, vol. 39, no. 16, pp. 4761–4768, 2000
  34. Fluorophores Related to the Green Fluorescent Protein and Their Use in Optoelectronic Devices
    Advanced Materials, vol. 12, no. 22, pp. 1678–1681, 2000
  35. Organic Letters, vol. 2, no. 20, pp. 3173–3176, 2000
  36. Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo
    Proceedings of the National Academy of Sciences, vol. 96, no. 14, pp. 8247–8252, 1999
  37. Lipoxin (LX)A4 and Aspirin-triggered 15-epi-LXA4 Inhibit Tumor Necrosis Factor 1alpha -initiated Neutrophil Responses and Trafficking: Regulators of a Cytokine-Chemokine Axis
    Journal of Experimental Medicine, vol. 189, no. 12, pp. 1923–1930, 1999
  38. Journal of the American Chemical Society, vol. 120, no. 45, pp. 11798–11799, 1998
  39. Mild Preparation of Haloarenes by Ipso-Substitution of Arylboronic Acids with N-Halosuccinimides
    Synlett, vol. 1998, no. 2, pp. 141–142, 1998
  40. Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: Role of P-selectin
    Proceedings of the National Academy of Sciences, vol. 94, no. 18, pp. 9967–9972, 1997
  41. Lipoxin A4 Stable Analogs Are Potent Mimetics That Stimulate Human Monocytes and THP-1 Cells via a G-protein-linked Lipoxin A4 Receptor
    Journal of Biological Chemistry, vol. 272, no. 11, pp. 6972–6978, 1997
  42. Nature, vol. 389, no. 6654, pp. 985–990, 1997
  43. Journal of the American Chemical Society, vol. 119, no. 2, pp. 445–446, 1997
  44. Aspirin-triggered 15-Epi-Lipoxin A4 (LXA4) and LXA4 Stable Analogues Are Potent Inhibitors of Acute Inflammation: Evidence for Anti-inflammatory Receptors
    Journal of Experimental Medicine, vol. 185, no. 9, pp. 1693–1704, 1997
  45. Journal of Organic Chemistry, vol. 62, no. 4, pp. 782–783, 1997
  46. A new synthesis of a-arylglycines from aryl boronic acids
    Tetrahedron, vol. 53, no. 48, pp. 16463–16470, 1997
  47. Mild conversion of alkenyl boronic acids to alkenyl halides with halosuccinimides
    Tetrahedron Letters, vol. 37, no. 5, pp. 567–570, 1996
  48. Stereocontrolled synthesis of substituted tetrahydropyrans from 1,3-dioxan-4-ones
    Tetrahedron Letters, vol. 37, no. 2, pp. 141–144, 1996
  49. Synthesis of Substituted Benzonorbornadienes from Cyclobutenediones
    Synlett, vol. 1996, no. 02, pp. 155–156, 1996
  50. Organotitanium compounds in organic synthesis
    Pure and Applied Chemistry, vol. 68, no. 3, pp. 667–670, 1996
  51. Journal of the American Chemical Society, vol. 117, no. 23, pp. 6394–6395, 1995
  52. Titanium-mediated olefinations of cyclobutenedione derivatives
    Tetrahedron Letters, vol. 36, no. 34, pp. 6001–6004, 1995
  53. Tris(trimethylsilyl) titanacyclobutene: A new mild reagent for the conversion of carbonyls to alkenyl silanes
    Tetrahedron Letters, vol. 36, no. 21, pp. 3619–3622, 1995
  54. Methylenations of heteroatom-substituted carbonyls with dimethyl titanocene
    Tetrahedron Letters, vol. 36, no. 14, pp. 2393–2396, 1995
  55. Spectroscopic, crystallographic and computational studies of the formation and isomerization of cyclic acetals and ketals of pentonolactones
    Tetrahedron: Asymmetry, vol. 5, no. 12, pp. 2535–2562, 1994
  56. Biscyclopropyl titanocene: A novel reagent for the synthesis of alkylidene and vinyl cyclopropanes
    Tetrahedron Letters, vol. 34, no. 6, pp. 943–946, 1993
  57. Investigations of the formation of cyclic acetal and ketal derivatives of D-ribono-1,4-lactone and 2-deoxy-D-ribono-1,4-lactone
    Tetrahedron, vol. 49, no. 29, pp. 349–362, 1993
  58. The boronic acid mannich reaction: A new method for the synthesis of geometrically pure allylamines
    Tetrahedron Letters, vol. 34, no. 42, pp. 583–586, 1993
  59. Alicyclic claisen rearrangement with a two-atom ring contraction. A new synthetic approach to cembranoids
    Tetrahedron Letters, vol. 34, no. 11, pp. 1721–1724, 1993
  60. Journal of the American Chemical Society, vol. 115, no. 16, pp. 7208–7214, 1993
  61. Organometallics, vol. 12, no. 9, pp. 3776–3780, 1993
  62. Journal of the American Chemical Society, vol. 114, no. 26, pp. 10328–10334, 1992
  63. Journal of Organic Chemistry, vol. 57, no. 5, pp. 1327–1330, 1992
  64. The synthesis of carbocyclic eight-membered rings
    Tetrahedron, vol. 48, no. 28, pp. 5757–5821, 1992
  65. Lipoxins and Related Eicosanoids: Biosynthesis, Biological Properties, and Chemical Synthesis
    Angewandte Chemie International Edition in English, vol. 30, no. 9, pp. 1100–1116, 1991
  66. A claisen rearrangement strategy for the three-atom ring expansion of cyclic ketones. A total synthesis of (±) precapnelladiene
    Tetrahedron Letters, vol. 31, no. 47, pp. 6799–6802, 1990
  67. Journal of the American Chemical Society, vol. 112, no. 17, pp. 6392–6394, 1990
  68. Journal of Organic Chemistry, vol. 48, no. 26, pp. 5400–5403, 1983
  69. Journal of Organic Chemistry, vol. 48, no. 26, pp. 5403–5404, 1983
  70. Journal of the American Chemical Society, vol. 104, no. 20, pp. 5557–5558, 1982
  71. Journal of the American Chemical Society, vol. 104, no. 20, pp. 5558–5560, 1982
  72. Journal of the American Chemical Society, vol. 104, no. 20, pp. 5560–5562, 1982
  73. Selective inhibition of 5-lipoxygenase by 5,6-methanoleukotriene A4, a stable analogue of leukotriene A4
    FEBS Letters, vol. 143, no. 1, pp. 13–16, 1982
  74. Journal of the American Chemical Society, vol. 104, no. 20, pp. 5555–5557, 1982
  75. Journal of Organic Chemistry, vol. 44, no. 22, pp. 4011–4013, 1979