Nicos A. Petasis
Nicos A. Petasis received his B.S. degree in chemistry from the Aristotle University of Thessaloniki, in Greece, and his Ph.D. degree in organic chemistry from the University of Pennsylvania in Philadelphia, Pa, USA. He is currently the Harold E. & Lillian M. Moulton Professor of Chemistry at the University of Southern California, where he is also a Member of the Loker Hydrocarbon Research Institute and the Norris Comprehensive Cancer Center. His work on new methods and strategies for organic synthesis has led to several widely used chemical reactions, including the titanium-mediated carbonyl olefination, and the multicomponent reactions of organoboron compounds with amines and carbonyls. His collaborative research on polyunsaturated lipid mediators has helped elucidate the beneficial roles of omega-3 fatty acids, and led to a number of new anti-inflammatory agents. He has given over 150 invited lectures worldwide and his work led to 2 books, over 130 papers, 115 conference presentations, and 40 patents and patent applications. He has also been a scientific advisor to the pharmaceutical industry, and for 2007-2008 he is the recipient of a worldwide Chemistry Lectureship from Novartis.
Biography Updated on 31 December 2007
Personal Home Page
http://www-bcf.usc.edu/~petasis/
Articles in Scholarly Journals [Incomplete List]
- Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties
Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 4, pp. 1382–1387, 2008 - COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro
Molecular Cancer, vol. 7, no. 1, p. 38, 2008 - Aggravated Endoplasmic Reticulum Stress as a Basis for Enhanced Glioblastoma Cell Killing by Bortezomib in Combination with Celecoxib or Its Non-Coxib Analogue, 2,5-Dimethyl-Celecoxib
Cancer Research, vol. 68, no. 3, pp. 843–851, 2008 - Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs
Expert Opinion on Investigational Drugs, vol. 17, no. 2, pp. 197–208, 2008 - Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib
Molecular Cancer Therapeutics, vol. 6, no. 4, pp. 1262–1275, 2007 - Resolvin D1 and Its Aspirin-triggered 17R Epimer: STEREOCHEMICAL ASSIGNMENTS, ANTI-INFLAMMATORY PROPERTIES, AND ENZYMATIC INACTIVATION
Journal of Biological Chemistry, vol. 282, no. 13, pp. 9323–9334, 2007 - Expanding Roles for Organoboron Compounds – Versatile and Valuable Molecules for Synthetic, Biological and Medicinal Chemistry
Australian Journal of Chemistry, vol. 60, no. 11, p. 795, 2007 - Simultaneous lipidomic analysis of three families of bioactive lipid mediators leukotrienes, resolvins, protectins and related hydroxy-fatty acids by liquid chromatography/electrospray ionisation tandem mass spectrometry
Rapid Communications in Mass Spectrometry, vol. 22, no. 2, pp. 75–83, 2007 - Resolvin D1, Protectin D1, and Related Docosahexaenoic Acid-Derived Products: Analysis via Electrospray/Low Energy Tandem Mass Spectrometry Based on Spectra and Fragmentation Mechanisms
Journal of the American Society for Mass Spectrometry, vol. 18, no. 1, pp. 128–144, 2007 - Identification of endogenous resolvin E1 and other lipid mediators derived from eicosapentaenoic acid via electrospray low-energy tandem mass spectrometry: spectra and fragmentation mechanisms
Rapid Communications in Mass Spectrometry, vol. 21, no. 1, pp. 7–22, 2006 - Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury
Journal of Experimental Medicine, vol. 203, no. 4, pp. 857–863, 2006 - Metabolic Inactivation of Resolvin E1 and Stabilization of Its Anti-inflammatory Actions
Journal of Biological Chemistry, vol. 281, no. 32, pp. 22847–22854, 2006 - Molecular Cancer, vol. 5, no. 1, p. 19, 2006
- RvE1 protects from local inflammation and osteoclast-mediated bone destruction in periodontitis
The FASEB Journal, 2005 - Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis
Proceedings of the National Academy of Sciences, vol. 102, no. 21, pp. 7671–7676, 2005 - Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib
Blood, vol. 106, no. 13, pp. 4330–4338, 2005 - Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo
British Journal of Pharmacology, vol. 146, no. 3, Article ID 0706338, 7 pages, 2005 - Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
Journal of Experimental Medicine, vol. 201, no. 5, pp. 713–722, 2005 - Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins
Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 73, no. 3-4, pp. 301–321, 2005 - Cystic fibrosis and lipoxins
Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 73, no. 3-4, pp. 263–270, 2005 - Dimethyl celecoxib as a novel non–cyclooxygenase 2 therapy in the treatment of non–small cell lung cancer
Journal of Thoracic and Cardiovascular Surgery, vol. 130, no. 5, pp. 1406–1412, 2005 - Organic Letters, vol. 6, no. 13, pp. 2205–2207, 2004
- Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway
Nature Immunology, vol. 5, no. 4, Article ID ni1056, 4 pages, 2004 - Interactions Between Lipoxin A4, the Stable Analogue 16-phenoxy-lipoxin A4 and Leukotriene B4 in Cytokine Generation by Human Monocytes
Scandinavian Journal of Immunology, vol. 60, no. 3, pp. 249–256, 2004 - 15-Epi-16-(Para-Fluorophenoxy)-Lipoxin A4-Methyl Ester, a Synthetic Analogue of 15-epi-Lipoxin A4, Is Protective in Experimental Ischemic Acute Renal Failure
Journal of the American Society of Nephrology, vol. 13, no. 6, pp. 1657–1662, 2002 - Lipoxins, Aspirin-Triggered Epi-Lipoxins, Lipoxin Stable Analogues, and the Resolution of Inflammation: Stimulation of Macrophage Phagocytosis of Apoptotic Neutrophils In Vivo
Journal of the American Society of Nephrology, vol. 13, no. 10, pp. 2497–2507, 2002 - Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes
Proceedings of the National Academy of Sciences, vol. 99, no. 20, pp. 13266–13271, 2002 - The Journal of Organic Chemistry, vol. 67, no. 11, pp. 3718–3723, 2002
- The Journal of Organic Chemistry, vol. 67, no. 17, pp. 6286–6286, 2002
- One-step three-component reaction among organoboronic acids, amines and salicylaldehydes
Tetrahedron Letters, vol. 42, no. 49, pp. 539–542, 2001 - Journal of Organic Chemistry, vol. 66, no. 2, pp. 633–634, 2001
- Synthesis of piperazinones and benzopiperazinones from 1,2-diamines and organoboronic acids
Tetrahedron Letters, vol. 41, no. 49, pp. 9607–9611, 2000 - Biochemistry, vol. 39, no. 16, pp. 4761–4768, 2000
- Fluorophores Related to the Green Fluorescent Protein and Their Use in Optoelectronic Devices
Advanced Materials, vol. 12, no. 22, pp. 1678–1681, 2000 - Organic Letters, vol. 2, no. 20, pp. 3173–3176, 2000
- Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo
Proceedings of the National Academy of Sciences, vol. 96, no. 14, pp. 8247–8252, 1999 - Lipoxin (LX)A4 and Aspirin-triggered 15-epi-LXA4 Inhibit Tumor Necrosis Factor 1alpha -initiated Neutrophil Responses and Trafficking: Regulators of a Cytokine-Chemokine Axis
Journal of Experimental Medicine, vol. 189, no. 12, pp. 1923–1930, 1999 - Journal of the American Chemical Society, vol. 120, no. 45, pp. 11798–11799, 1998
- Mild Preparation of Haloarenes by Ipso-Substitution of Arylboronic Acids with N-Halosuccinimides
Synlett, vol. 1998, no. 2, pp. 141–142, 1998 - Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: Role of P-selectin
Proceedings of the National Academy of Sciences, vol. 94, no. 18, pp. 9967–9972, 1997 - Lipoxin A4 Stable Analogs Are Potent Mimetics That Stimulate Human Monocytes and THP-1 Cells via a G-protein-linked Lipoxin A4 Receptor
Journal of Biological Chemistry, vol. 272, no. 11, pp. 6972–6978, 1997 - Nature, vol. 389, no. 6654, pp. 985–990, 1997
- Journal of the American Chemical Society, vol. 119, no. 2, pp. 445–446, 1997
- Aspirin-triggered 15-Epi-Lipoxin A4 (LXA4) and LXA4 Stable Analogues Are Potent Inhibitors of Acute Inflammation: Evidence for Anti-inflammatory Receptors
Journal of Experimental Medicine, vol. 185, no. 9, pp. 1693–1704, 1997 - Journal of Organic Chemistry, vol. 62, no. 4, pp. 782–783, 1997
- A new synthesis of a-arylglycines from aryl boronic acids
Tetrahedron, vol. 53, no. 48, pp. 16463–16470, 1997 - Mild conversion of alkenyl boronic acids to alkenyl halides with halosuccinimides
Tetrahedron Letters, vol. 37, no. 5, pp. 567–570, 1996 - Stereocontrolled synthesis of substituted tetrahydropyrans from 1,3-dioxan-4-ones
Tetrahedron Letters, vol. 37, no. 2, pp. 141–144, 1996 - Synthesis of Substituted Benzonorbornadienes from Cyclobutenediones
Synlett, vol. 1996, no. 02, pp. 155–156, 1996 - Organotitanium compounds in organic synthesis
Pure and Applied Chemistry, vol. 68, no. 3, pp. 667–670, 1996 - Journal of the American Chemical Society, vol. 117, no. 23, pp. 6394–6395, 1995
- Titanium-mediated olefinations of cyclobutenedione derivatives
Tetrahedron Letters, vol. 36, no. 34, pp. 6001–6004, 1995 - Tris(trimethylsilyl) titanacyclobutene: A new mild reagent for the conversion of carbonyls to alkenyl silanes
Tetrahedron Letters, vol. 36, no. 21, pp. 3619–3622, 1995 - Methylenations of heteroatom-substituted carbonyls with dimethyl titanocene
Tetrahedron Letters, vol. 36, no. 14, pp. 2393–2396, 1995 - Spectroscopic, crystallographic and computational studies of the formation and isomerization of cyclic acetals and ketals of pentonolactones
Tetrahedron: Asymmetry, vol. 5, no. 12, pp. 2535–2562, 1994 - Biscyclopropyl titanocene: A novel reagent for the synthesis of alkylidene and vinyl cyclopropanes
Tetrahedron Letters, vol. 34, no. 6, pp. 943–946, 1993 - Investigations of the formation of cyclic acetal and ketal derivatives of D-ribono-1,4-lactone and 2-deoxy-D-ribono-1,4-lactone
Tetrahedron, vol. 49, no. 29, pp. 349–362, 1993 - The boronic acid mannich reaction: A new method for the synthesis of geometrically pure allylamines
Tetrahedron Letters, vol. 34, no. 42, pp. 583–586, 1993 - Alicyclic claisen rearrangement with a two-atom ring contraction. A new synthetic approach to cembranoids
Tetrahedron Letters, vol. 34, no. 11, pp. 1721–1724, 1993 - Journal of the American Chemical Society, vol. 115, no. 16, pp. 7208–7214, 1993
- Organometallics, vol. 12, no. 9, pp. 3776–3780, 1993
- Journal of the American Chemical Society, vol. 114, no. 26, pp. 10328–10334, 1992
- Journal of Organic Chemistry, vol. 57, no. 5, pp. 1327–1330, 1992
- The synthesis of carbocyclic eight-membered rings
Tetrahedron, vol. 48, no. 28, pp. 5757–5821, 1992 - Lipoxins and Related Eicosanoids: Biosynthesis, Biological Properties, and Chemical Synthesis
Angewandte Chemie International Edition in English, vol. 30, no. 9, pp. 1100–1116, 1991 - A claisen rearrangement strategy for the three-atom ring expansion of cyclic ketones. A total synthesis of (±) precapnelladiene
Tetrahedron Letters, vol. 31, no. 47, pp. 6799–6802, 1990 - Journal of the American Chemical Society, vol. 112, no. 17, pp. 6392–6394, 1990
- Journal of Organic Chemistry, vol. 48, no. 26, pp. 5400–5403, 1983
- Journal of Organic Chemistry, vol. 48, no. 26, pp. 5403–5404, 1983
- Journal of the American Chemical Society, vol. 104, no. 20, pp. 5557–5558, 1982
- Journal of the American Chemical Society, vol. 104, no. 20, pp. 5558–5560, 1982
- Journal of the American Chemical Society, vol. 104, no. 20, pp. 5560–5562, 1982
- Selective inhibition of 5-lipoxygenase by 5,6-methanoleukotriene A4, a stable analogue of leukotriene A4
FEBS Letters, vol. 143, no. 1, pp. 13–16, 1982 - Journal of the American Chemical Society, vol. 104, no. 20, pp. 5555–5557, 1982
- Journal of Organic Chemistry, vol. 44, no. 22, pp. 4011–4013, 1979