Leif Bergsagel received an undergraduate degree in mathematics and a graduate degree in medicine from the University of Toronto, and completed a residency in internal medicine at the University of Toronto. He completed a fellowship in medical oncology at the National Cancer Institute, Bethesda, Md, USA. After working for nine years at Cornell University, he moved to Mayo Clinic where he is currently a Professor of medicine. He is a Scientific Advisory Board Member for the Multiple Myeloma Research Foundation (MMRF). His research is currently funded by a grant from Specialized Program of Research Excellence (SPORE) in Multiple Myeloma at the National Cancer Institute, and an R01 from the National Institutes of Health. His numerous awards include the 2007 Senior Investigator Award from the MMRF and the 1998 Translational Research Award from The Leukemia and Lymphoma Society. Dr. Bergsagel has coauthored many publications in peer-reviewed journals and has spoken at numerous national and international meetings. His research is focused on the understanding of the molecular pathogenesis of multiple myeloma. His seminal contributions to myeloma research include identifying recurrent immunoglobulin gene translocations, identifying and cloning the t(11;14), t(4;14), t(14;16), t(6;14), and t(14;20) translocation breakpoints, identifying recurrent MYC translocations and p18 inactivation, developing a comprehensive molecular classification of myeloma, identifying cyclin D dysregulation as a universal event in the pathogenesis of myeloma, identifying promiscuous mutations that activate the NFkB pathway, and developing a faithful mouse model of myeloma.
Biography Updated on 9 June 2008