Peter G. Shields
Peter Shields is currently a Full Professor in
the Departments of Oncology and Medicine
at Georgetown University. He is the Associate
Director for Cancer Control and Population
Sciences in the Lombardi Comprehensive
Cancer Center, and the Program
Leader for Cancer Genetics and Epidemiology.
Also, he is the Director of the Division
of Cancer Genetics and Epidemiology in the
Department of Oncology. Dr. Shields' focus
of research is on gene-environment interactions for cancer risk.
The laboratory component of his research develops new biomarkers
of cancer risk, while his epidemiological component accrues
special populations. A major initiative that is led by Dr. Shields
is a Breast Cancer Center of Excellence. This program is a multiinvestigator
and multidisciplinary approach to understand why alcohol
drinking causes breast cancer. Dr. Shields has over 120 peerreviewed
publications, included in high profile journals. He serves,
or has served, on editorial boards of major journals such as Carcinogenesis
and Cancer, Epidemiology, Biomarkers and Prevention.
At Georgetown University, he is a Member of the Lombardi
Comprehensive Cancer Center Executive Committee, the oversight
committee for the Tumor Biology program, and the M.D.-Ph.D.
program.
Biography Updated on 18 May 2006
Personal Home Page
http://explore.georgetown.edu/people/pgs2/?PageTemplateID=147http://explore.georgetown.edu/people/pgs2/?PageTemplateID=147
Articles in Scholarly Journals [Incomplete List]
- Can the blind see Participant guess about treatment arm assignment may influence outcome in a clinical trial of bupropion for smoking cessation
Journal of Substance Abuse Treatment, vol. 34, no. 2, pp. 234–241, 2008 - Cigarette Smoking, N-Acetyltransferase 2 Genotypes, and Breast Cancer Risk: Pooled Analysis and Meta-analysis
Cancer Epidemiology Biomarkers & Prevention, vol. 17, no. 1, pp. 15–26, 2008 - Changes in 2-Hydroxyestrone and 16 -Hydroxyestrone Metabolism with Flaxseed Consumption: Modification by COMT and CYP1B1 Genotype
Cancer Epidemiology Biomarkers & Prevention, vol. 16, no. 2, pp. 256–262, 2007 - Common Genetic Variation in TP53 Is Associated with Lung Cancer Risk and Prognosis in African Americans and Somatic Mutations in Lung Tumors
Cancer Epidemiology Biomarkers & Prevention, vol. 16, no. 2, pp. 214–222, 2007 - Mutagen Sensitivity and Genetic Variants in Nucleotide Excision Repair Pathway: Genotype-Phenotype Correlation
Cancer Epidemiology Biomarkers & Prevention, vol. 16, no. 10, pp. 2065–2071, 2007 - CYP2B6 Genotype Does Not Alter Nicotine Metabolism, Plasma Levels, or Abstinence with Nicotine Replacement Therapy
Cancer Epidemiology Biomarkers & Prevention, vol. 16, no. 6, pp. 1312–1314, 2007 - The Role of CYP2A6 in the Emergence of Nicotine Dependence in Adolescents
PEDIATRICS, vol. 119, no. 1, pp. e264–e274, 2007 - Catechol-O-Methyltransferase (COMT) Gene Variants Predict Response to Bupropion Therapy for Tobacco Dependence
Biological Psychiatry, vol. 61, no. 1, pp. 111–118, 2007 - Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation
Nicotine & Tobacco Research, vol. 9, no. 8, pp. 821–833, 2007 - Bupropion efficacy for smoking cessation is influenced by the DRD2 Taq1A polymorphism: Analysis of pooled data from two clinical trials
Nicotine & Tobacco Research, vol. 9, no. 12, pp. 1251–1257, 2007 - Re: Commonly Studied Single-Nucleotide Polymorphisms and Breast Cancer: Results From the Breast Cancer Association Consortium
JNCI Journal of the National Cancer Institute, vol. 99, no. 6, pp. 487–487, 2007 - Lung Cancer Survival and Functional Polymorphisms in MBL2, an Innate-Immunity Gene
JNCI Journal of the National Cancer Institute, vol. 99, no. 18, pp. 1401–1409, 2007 - Accurate genotyping from paraffin-embedded normal tissue adjacent to breast cancer
Carcinogenesis, vol. 27, no. 2, pp. 307–310, 2006 - Cancer Survivorship--Genetic Susceptibility and Second Primary Cancers: Research Strategies and Recommendations
CancerSpectrum Knowledge Environment, vol. 98, no. 1, pp. 15–25, 2006 - Meta- and Pooled Analysis of GSTT1 and Lung Cancer: A HuGE-GSEC Review
American Journal of Epidemiology, vol. 164, no. 11, pp. 1027–1042, 2006 - Formaldehyde as a Potential Human Leukemogen: An Assessment of Biological Plausibility
Critical Reviews in Toxicology, vol. 36, no. 2, pp. 135–153, 2006 - No Evidence for a Major Role of Polymorphisms During Bupropion Treatment*
Obesity, vol. 14, no. 11, Article ID oby2006215, 4 pages, 2006 - Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation
Clinical Pharmacology & Therapeutics, vol. 79, no. 6, pp. 600–608, 2006 - Alcohol drinking and breast cancer
Breast Cancer Online, vol. 9, no. 04, 2006 - Effect of Team Sport Participation on Genetic Predisposition to Adolescent Smoking Progression
Archives of General Psychiatry, vol. 63, no. 4, pp. 433–441, 2006 - Mutagen Sensitivity Has High Heritability: Evidence from a Twin Study
Cancer Research, vol. 66, no. 12, pp. 5993–5996, 2006 - Nonrigid Medical Image Registration by Finite-Element Deformable Sheet-Curve Models
International Journal of Biomedical Imaging, vol. 2006, Article ID 73430, 9 pages, 2006 - -Radiation-Induced Chromosomal Mutagen Sensitivity Is Associated with Breast Cancer Risk in African-American Women: Caffeine Modulates the Outcome of Mutagen Sensitivity Assay
Cancer Epidemiology Biomarkers & Prevention, vol. 15, no. 3, pp. 437–442, 2006 - p53 Mutation Analysis in Breast Tumors by a DNA Microarray Method
Cancer Epidemiology Biomarkers & Prevention, vol. 15, no. 1, pp. 80–85, 2006 - Lack of Association of 5-HTTLPR Genotype with Smoking Cessation in a Nicotine Replacement Therapy Randomized Trial
Cancer Epidemiology Biomarkers & Prevention, vol. 15, no. 2, pp. 398–400, 2006 - MDM2 SNP309 and SNP354 Are Not Associated with Lung Cancer Risk
Cancer Epidemiology Biomarkers & Prevention, vol. 15, no. 8, pp. 1559–1561, 2006 - Understanding Population and Individual Risk Assessment: The Case of Polychlorinated Biphenyls
Cancer Epidemiology Biomarkers & Prevention, vol. 15, no. 5, pp. 830–839, 2006 - Less Efficient G2-M Checkpoint Is Associated with an Increased Risk of Lung Cancer in African Americans
Cancer Research, vol. 65, no. 20, pp. 9566–9573, 2005 - Association of catechol-O-methyltransferase with smoking cessation in two independent studies of women
Pharmacogenetics and Genomics, vol. 15, no. 6, pp. 393–398, 2005 - TP53 Mutation Spectrum in Lung Cancer Is Not Different in Women and Men
Cancer Epidemiology Biomarkers & Prevention, vol. 14, no. 4, pp. 1031–1033, 2005 - Catechol-O-Methyl-Transferase Functional Polymorphism and Nicotine Dependence: an Evaluation of Nonreplicated Results
Cancer Epidemiology Biomarkers & Prevention, vol. 14, no. 6, pp. 1384–1389, 2005 - p53 Mutations in hepatocellular carcinoma patients in Egypt
International Journal of Hygiene and Environmental Health, vol. 208, no. 4, pp. 263–270, 2005 - The etiology of alcohol-induced breast cancer
Alcohol, vol. 35, no. 3, pp. 213–225, 2005 - Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
International Journal of Cancer, vol. 110, no. 2, pp. 266–270, 2004 - The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial
The Pharmacogenomics Journal, vol. 4, no. 3, Article ID 6500238, 8 pages, 2004 - Diet and alcohol consumption in relation to p53 mutations in breast tumors
Carcinogenesis, vol. 25, no. 6, pp. 931–939, 2004 - Polymorphisms in XPD and TP53 and mutation in human lung cancer
Carcinogenesis, vol. 26, no. 3, pp. 597–604, 2004 - Interacting Effects of Genetic Predisposition and Depression on Adolescent Smoking Progression
American Journal of Psychiatry, vol. 161, no. 7, pp. 1224–1230, 2004 - Cruciferous Vegetables, Genetic Polymorphisms in Glutathione S-Transferases M1 and T1, and Prostate Cancer Risk
Nutrition and Cancer, vol. 50, no. 2, pp. 206–213, 2004 - Bleomycin-induced chromosome breaks as a risk marker for lung cancer: a case-control study with population and hospital controls
Carcinogenesis, vol. 24, no. 2, pp. 269–274, 2003 - Bleomycin-induced chromosome breaks as a risk marker for lung cancer: a case-control study with population and hospital controls
Carcinogenesis, vol. 24, no. 8, pp. 1425–1425, 2003 - CYP1A1 T3801 C polymorphism and lung cancer: A pooled analysis of 2,451 cases and 3,358 controls
International Journal of Cancer, vol. 104, no. 5, pp. 650–657, 2003 - Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain
Neuropharmacology, vol. 45, no. 1, pp. 122–132, 2003 - Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial.
Health Psychology, vol. 22, no. 5, Article ID 2003-08468-014, 7 pages, 2003 - Carcinogens in the workplace
Clinics in Occupational and Environmental Medicine, vol. 2, no. 4, pp. xi–xii, 2002 - Lung cancer risks in women with previous breast cancer
European Journal of Cancer, vol. 38, no. 11, pp. 1520–1525, 2002 - Neurobehavioral disturbances arising from occupational toluene exposure
American Journal of Industrial Medicine, vol. 41, no. 2, pp. 77–88, 2002 - Erratum
Carcinogenesis, vol. 23, no. 10, pp. 1771–1772, 2002 - Skilled use of DNA polymorphisms as a tool for polygenic cancers
Carcinogenesis, vol. 23, no. 3, pp. 379–380, 2002 - Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk
Carcinogenesis, vol. 23, no. 8, pp. 1343–1350, 2002 - Pharmacogenetic investigation of smoking cessation treatment
Pharmacogenetics, vol. 12, no. 8, pp. 627–634, 2002 - Molecular epidemiology of smoking and lung cancer
Oncogene, vol. 21, no. 45, Article ID 1205832, 6 pages, 2002 - Microsomal epoxide hydrolase polymorphisms and lung cancer risk: a quantitative review
Biomarkers, vol. 7, no. 3, pp. 230–241, 2002 - Genetic polymorphisms in DNA repair genes and risk of lung cancer
Carcinogenesis, vol. 22, no. 4, pp. 593–597, 2001 - Tryptophan hydroxylase gene variant and smoking behavior
American Journal of Medical Genetics, vol. 105, no. 6, pp. 518–520, 2001 - Apolipoprotein E genetic polymorphism, serum lipoproteins, and breast cancer risk
Molecular Carcinogenesis, vol. 27, no. 1, pp. 2–9, 2000 - Epidemiology of tobacco carcinogenesis
Current Oncology Reports, vol. 2, no. 3, pp. 257–262, 2000 - Quantitation of benzo[a]pyrene-DNA adducts by postlabeling with 14C-acetic anhydride and accelerator mass spectrometry
Chemico-Biological Interactions, vol. 126, no. 3, pp. 171–183, 2000 - Interacting effects of the serotonin transporter gene and neuroticism in smoking practices and nicotine dependence
Molecular Psychiatry, vol. 5, no. 2, pp. 189–192, 2000 - Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: Oxyradical overload diseases
Proceedings of the National Academy of Sciences, vol. 97, no. 23, pp. 12770–12775, 2000 - A liquid helium cryostat for the study of pressure effects on hole burned spectra of hyperquenched glassy films
Review of Scientific Instruments, vol. 70, no. 5, p. 2454, 1999 - Molecular epidemiological study of non-small-cell lung cancer from an environmentally polluted region of Poland
British Journal of Cancer, vol. 80, no. 9, pp. 1445–1452, 1999 - The fast alternative cryogenic experiment testbed
Cryogenics, vol. 39, no. 12, pp. 1029–1035, 1999 - Cancer Causes and Control, vol. 10, no. 5, pp. 369–377, 1999
- Evidence suggesting the role of specific genetic factors in cigarette smoking.
Health Psychology, vol. 18, no. 1, Article ID 1998-03081-003, 6 pages, 1999 - Molecular epidemiology of human cancer risk: gene-environment interactions andp53 mutation spectrum in human lung cancer
The Journal of Pathology, vol. 187, no. 1, pp. 8–18, 1999 - An evaluation of proposed frameworks for grouping polychlorinated biphenyl (PCB) congener data into meaningful analytic units
American Journal of Industrial Medicine, vol. 35, no. 3, pp. 223–231, 1999 - Apolipoprotein E allelic frequency in elderly smokers
American Journal of Medical Genetics, vol. 76, no. 1, pp. 32–36, 1998 - Breast cancer risk, meat consumption and N-acetyltransferase (NAT2) genetic polymorphisms
International Journal of Cancer, vol. 75, no. 6, pp. 825–830, 1998 - Depression and self-medication with nicotine: The modifying influence of the dopamine D4 receptor gene.
Health Psychology, vol. 17, no. 1, Article ID 1997-42831-007, 6 pages, 1998 - Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues
European Journal of Cancer, vol. 34, no. 6, pp. 914–920, 1998 - p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer
Pharmacogenetics, vol. 8, no. 6, pp. 503–512, 1998 - Helicobacter pylori infection and genetic polymorphisms for cancer-related genes in gastric carcinogenesis
Biomedecine & Pharmacotherapy, vol. 51, no. 4, pp. 145–149, 1997 - Serum, plasma and paraffin-embedded tissues as sources of DNA for studying cancer susceptibility genes
Carcinogenesis, vol. 18, no. 6, pp. 1271–1275, 1997 - Lack of association of tyrosine hydroxylase genetic polymorphism with cigarette smoking
Pharmacogenetics, vol. 7, no. 6, pp. 521–524, 1997 - Chemicals and cancer
European Journal of Cancer Prevention, vol. 5, no. 5, pp. 391–404, 1996 - Distribution of 7-alkyl-2'-deoxyguanosine adduct levels in human lung
Carcinogenesis, vol. 17, no. 4, pp. 741–748, 1996 - Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk
JAMA: The Journal of the American Medical Association, vol. 276, no. 18, pp. 1494–1501, 1996 - A cytochrome P4502E1 genetic polymorphism and tobacco smoking in breast cancer
Molecular Carcinogenesis, vol. 17, no. 3, pp. 144–150, 1996 - Genetic polymorphisms of the cancer related gene andHelicobacter pylori infection in Japanese gastric cancer patients: An age and gender matched case–control study
Cancer, vol. 77, no. 8, pp. 1654–1661, 1996 - The impact of glutathiones-transferase M1 and cytochrome P450 1A1 genotypes on white-blood-cell polycyclic aromatic hydrocarbon-dna adduct levels in humans
Molecular Carcinogenesis, vol. 14, no. 1, pp. 63–68, 1995 - Cytochrome P45O2E1 (CYP2E1) genetic polymorphism in a case-control study of gastric cancer and liver disease
Pharmacogenetics, vol. 5, no. Special Issue, pp. S141–S144, 1995 - Confined Space Hazards: Combined Exposure to Styrene, Fiberglass, and Silica
Journal of Occupational and Environmental Medicine, vol. 37, no. 2, pp. 185–188, 1995 - The Association of Polymorphic N-Acetyltransferase (NAT2) with Breast Cancer Risk
Annals of the New York Academy of Sciences, vol. 768, no. 1, pp. 250–252, 1995 - Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans
Pharmacogenetics, vol. 4, no. 5, pp. 242–246, 1994 - Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens
Nature, vol. 369, no. 6476, Article ID 369154a0, 2 pages, 1994 - Susceptibility markers in normal subjects: A pilot study for the investigation of 2,3,7,8-tetrachlorodibenzo-p-dioxin related diseases
Chemosphere, vol. 27, no. 1-3, pp. 375–381, 1993 - Simian Virus 40 Large Tumor Antigen-Immortalized Normal Human Liver Epithelial Cells Express Hepatocyte Characteristics and Metabolize Chemical Carcinogens
Proceedings of the National Academy of Sciences, vol. 90, no. 11, pp. 5123–5127, 1993 - Genotoxicity of heated cooking oil vapors
Mutation Research/Genetic Toxicology, vol. 298, no. 2, pp. 105–111, 1992 - Molecular epidemiology and the genetics of environmental cancer
JAMA: The Journal of the American Medical Association, vol. 266, no. 5, pp. 681–687, 1991 - Subchronic Administration of Caffeine and Theophylline in Drinking Water: Effects on Rat Liver Rna Polymerase Activity
Drug and Chemical Toxicology, vol. 4, no. 2, pp. 89–100, 1981