Peter G. Shields

Peter Shields is currently a Full Professor in the Departments of Oncology and Medicine at Georgetown University. He is the Associate Director for Cancer Control and Population Sciences in the Lombardi Comprehensive Cancer Center, and the Program Leader for Cancer Genetics and Epidemiology. Also, he is the Director of the Division of Cancer Genetics and Epidemiology in the Department of Oncology. Dr. Shields' focus of research is on gene-environment interactions for cancer risk. The laboratory component of his research develops new biomarkers of cancer risk, while his epidemiological component accrues special populations. A major initiative that is led by Dr. Shields is a Breast Cancer Center of Excellence. This program is a multiinvestigator and multidisciplinary approach to understand why alcohol drinking causes breast cancer. Dr. Shields has over 120 peerreviewed publications, included in high profile journals. He serves, or has served, on editorial boards of major journals such as Carcinogenesis and Cancer, Epidemiology, Biomarkers and Prevention. At Georgetown University, he is a Member of the Lombardi Comprehensive Cancer Center Executive Committee, the oversight committee for the Tumor Biology program, and the M.D.-Ph.D. program.

Biography Updated on 18 May 2006

Personal Home Page

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Articles in Scholarly Journals [Incomplete List]

  1. Can the blind see Participant guess about treatment arm assignment may influence outcome in a clinical trial of bupropion for smoking cessation
    Journal of Substance Abuse Treatment, vol. 34, no. 2, pp. 234–241, 2008
  2. Cigarette Smoking, N-Acetyltransferase 2 Genotypes, and Breast Cancer Risk: Pooled Analysis and Meta-analysis
    Cancer Epidemiology Biomarkers & Prevention, vol. 17, no. 1, pp. 15–26, 2008
  3. Changes in 2-Hydroxyestrone and 16 -Hydroxyestrone Metabolism with Flaxseed Consumption: Modification by COMT and CYP1B1 Genotype
    Cancer Epidemiology Biomarkers & Prevention, vol. 16, no. 2, pp. 256–262, 2007
  4. Common Genetic Variation in TP53 Is Associated with Lung Cancer Risk and Prognosis in African Americans and Somatic Mutations in Lung Tumors
    Cancer Epidemiology Biomarkers & Prevention, vol. 16, no. 2, pp. 214–222, 2007
  5. Mutagen Sensitivity and Genetic Variants in Nucleotide Excision Repair Pathway: Genotype-Phenotype Correlation
    Cancer Epidemiology Biomarkers & Prevention, vol. 16, no. 10, pp. 2065–2071, 2007
  6. CYP2B6 Genotype Does Not Alter Nicotine Metabolism, Plasma Levels, or Abstinence with Nicotine Replacement Therapy
    Cancer Epidemiology Biomarkers & Prevention, vol. 16, no. 6, pp. 1312–1314, 2007
  7. The Role of CYP2A6 in the Emergence of Nicotine Dependence in Adolescents
    PEDIATRICS, vol. 119, no. 1, pp. e264–e274, 2007
  8. Catechol-O-Methyltransferase (COMT) Gene Variants Predict Response to Bupropion Therapy for Tobacco Dependence
    Biological Psychiatry, vol. 61, no. 1, pp. 111–118, 2007
  9. Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation
    Nicotine & Tobacco Research, vol. 9, no. 8, pp. 821–833, 2007
  10. Bupropion efficacy for smoking cessation is influenced by the DRD2 Taq1A polymorphism: Analysis of pooled data from two clinical trials
    Nicotine & Tobacco Research, vol. 9, no. 12, pp. 1251–1257, 2007
  11. Re: Commonly Studied Single-Nucleotide Polymorphisms and Breast Cancer: Results From the Breast Cancer Association Consortium
    JNCI Journal of the National Cancer Institute, vol. 99, no. 6, pp. 487–487, 2007
  12. Lung Cancer Survival and Functional Polymorphisms in MBL2, an Innate-Immunity Gene
    JNCI Journal of the National Cancer Institute, vol. 99, no. 18, pp. 1401–1409, 2007
  13. Accurate genotyping from paraffin-embedded normal tissue adjacent to breast cancer
    Carcinogenesis, vol. 27, no. 2, pp. 307–310, 2006
  14. Cancer Survivorship--Genetic Susceptibility and Second Primary Cancers: Research Strategies and Recommendations
    CancerSpectrum Knowledge Environment, vol. 98, no. 1, pp. 15–25, 2006
  15. Meta- and Pooled Analysis of GSTT1 and Lung Cancer: A HuGE-GSEC Review
    American Journal of Epidemiology, vol. 164, no. 11, pp. 1027–1042, 2006
  16. Formaldehyde as a Potential Human Leukemogen: An Assessment of Biological Plausibility
    Critical Reviews in Toxicology, vol. 36, no. 2, pp. 135–153, 2006
  17. No Evidence for a Major Role of Polymorphisms During Bupropion Treatment*
    Obesity, vol. 14, no. 11, Article ID oby2006215, 4 pages, 2006
  18. Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation
    Clinical Pharmacology & Therapeutics, vol. 79, no. 6, pp. 600–608, 2006
  19. Alcohol drinking and breast cancer
    Breast Cancer Online, vol. 9, no. 04, 2006
  20. Effect of Team Sport Participation on Genetic Predisposition to Adolescent Smoking Progression
    Archives of General Psychiatry, vol. 63, no. 4, pp. 433–441, 2006
  21. Mutagen Sensitivity Has High Heritability: Evidence from a Twin Study
    Cancer Research, vol. 66, no. 12, pp. 5993–5996, 2006
  22. Nonrigid Medical Image Registration by Finite-Element Deformable Sheet-Curve Models
    International Journal of Biomedical Imaging, vol. 2006, Article ID 73430, 9 pages, 2006
  23.  -Radiation-Induced Chromosomal Mutagen Sensitivity Is Associated with Breast Cancer Risk in African-American Women: Caffeine Modulates the Outcome of Mutagen Sensitivity Assay
    Cancer Epidemiology Biomarkers & Prevention, vol. 15, no. 3, pp. 437–442, 2006
  24. p53 Mutation Analysis in Breast Tumors by a DNA Microarray Method
    Cancer Epidemiology Biomarkers & Prevention, vol. 15, no. 1, pp. 80–85, 2006
  25. Lack of Association of 5-HTTLPR Genotype with Smoking Cessation in a Nicotine Replacement Therapy Randomized Trial
    Cancer Epidemiology Biomarkers & Prevention, vol. 15, no. 2, pp. 398–400, 2006
  26. MDM2 SNP309 and SNP354 Are Not Associated with Lung Cancer Risk
    Cancer Epidemiology Biomarkers & Prevention, vol. 15, no. 8, pp. 1559–1561, 2006
  27. Understanding Population and Individual Risk Assessment: The Case of Polychlorinated Biphenyls
    Cancer Epidemiology Biomarkers & Prevention, vol. 15, no. 5, pp. 830–839, 2006
  28. Less Efficient G2-M Checkpoint Is Associated with an Increased Risk of Lung Cancer in African Americans
    Cancer Research, vol. 65, no. 20, pp. 9566–9573, 2005
  29. Association of catechol-O-methyltransferase with smoking cessation in two independent studies of women
    Pharmacogenetics and Genomics, vol. 15, no. 6, pp. 393–398, 2005
  30. TP53 Mutation Spectrum in Lung Cancer Is Not Different in Women and Men
    Cancer Epidemiology Biomarkers & Prevention, vol. 14, no. 4, pp. 1031–1033, 2005
  31. Catechol-O-Methyl-Transferase Functional Polymorphism and Nicotine Dependence: an Evaluation of Nonreplicated Results
    Cancer Epidemiology Biomarkers & Prevention, vol. 14, no. 6, pp. 1384–1389, 2005
  32. p53 Mutations in hepatocellular carcinoma patients in Egypt
    International Journal of Hygiene and Environmental Health, vol. 208, no. 4, pp. 263–270, 2005
  33. The etiology of alcohol-induced breast cancer
    Alcohol, vol. 35, no. 3, pp. 213–225, 2005
  34. Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
    International Journal of Cancer, vol. 110, no. 2, pp. 266–270, 2004
  35. The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial
    The Pharmacogenomics Journal, vol. 4, no. 3, Article ID 6500238, 8 pages, 2004
  36. Diet and alcohol consumption in relation to p53 mutations in breast tumors
    Carcinogenesis, vol. 25, no. 6, pp. 931–939, 2004
  37. Polymorphisms in XPD and TP53 and mutation in human lung cancer
    Carcinogenesis, vol. 26, no. 3, pp. 597–604, 2004
  38. Interacting Effects of Genetic Predisposition and Depression on Adolescent Smoking Progression
    American Journal of Psychiatry, vol. 161, no. 7, pp. 1224–1230, 2004
  39. Cruciferous Vegetables, Genetic Polymorphisms in Glutathione S-Transferases M1 and T1, and Prostate Cancer Risk
    Nutrition and Cancer, vol. 50, no. 2, pp. 206–213, 2004
  40. Bleomycin-induced chromosome breaks as a risk marker for lung cancer: a case-control study with population and hospital controls
    Carcinogenesis, vol. 24, no. 2, pp. 269–274, 2003
  41. Bleomycin-induced chromosome breaks as a risk marker for lung cancer: a case-control study with population and hospital controls
    Carcinogenesis, vol. 24, no. 8, pp. 1425–1425, 2003
  42. CYP1A1 T3801 C polymorphism and lung cancer: A pooled analysis of 2,451 cases and 3,358 controls
    International Journal of Cancer, vol. 104, no. 5, pp. 650–657, 2003
  43. Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain
    Neuropharmacology, vol. 45, no. 1, pp. 122–132, 2003
  44. Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial.
    Health Psychology, vol. 22, no. 5, Article ID 2003-08468-014, 7 pages, 2003
  45. Carcinogens in the workplace
    Clinics in Occupational and Environmental Medicine, vol. 2, no. 4, pp. xi–xii, 2002
  46. Lung cancer risks in women with previous breast cancer
    European Journal of Cancer, vol. 38, no. 11, pp. 1520–1525, 2002
  47. Neurobehavioral disturbances arising from occupational toluene exposure
    American Journal of Industrial Medicine, vol. 41, no. 2, pp. 77–88, 2002
  48. Erratum
    Carcinogenesis, vol. 23, no. 10, pp. 1771–1772, 2002
  49. Skilled use of DNA polymorphisms as a tool for polygenic cancers
    Carcinogenesis, vol. 23, no. 3, pp. 379–380, 2002
  50. Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk
    Carcinogenesis, vol. 23, no. 8, pp. 1343–1350, 2002
  51. Pharmacogenetic investigation of smoking cessation treatment
    Pharmacogenetics, vol. 12, no. 8, pp. 627–634, 2002
  52. Molecular epidemiology of smoking and lung cancer
    Oncogene, vol. 21, no. 45, Article ID 1205832, 6 pages, 2002
  53. Microsomal epoxide hydrolase polymorphisms and lung cancer risk: a quantitative review
    Biomarkers, vol. 7, no. 3, pp. 230–241, 2002
  54. Genetic polymorphisms in DNA repair genes and risk of lung cancer
    Carcinogenesis, vol. 22, no. 4, pp. 593–597, 2001
  55. Tryptophan hydroxylase gene variant and smoking behavior
    American Journal of Medical Genetics, vol. 105, no. 6, pp. 518–520, 2001
  56. Apolipoprotein E genetic polymorphism, serum lipoproteins, and breast cancer risk
    Molecular Carcinogenesis, vol. 27, no. 1, pp. 2–9, 2000
  57. Epidemiology of tobacco carcinogenesis
    Current Oncology Reports, vol. 2, no. 3, pp. 257–262, 2000
  58. Quantitation of benzo[a]pyrene-DNA adducts by postlabeling with 14C-acetic anhydride and accelerator mass spectrometry
    Chemico-Biological Interactions, vol. 126, no. 3, pp. 171–183, 2000
  59. Interacting effects of the serotonin transporter gene and neuroticism in smoking practices and nicotine dependence
    Molecular Psychiatry, vol. 5, no. 2, pp. 189–192, 2000
  60. Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: Oxyradical overload diseases
    Proceedings of the National Academy of Sciences, vol. 97, no. 23, pp. 12770–12775, 2000
  61. A liquid helium cryostat for the study of pressure effects on hole burned spectra of hyperquenched glassy films
    Review of Scientific Instruments, vol. 70, no. 5, p. 2454, 1999
  62. Molecular epidemiological study of non-small-cell lung cancer from an environmentally polluted region of Poland
    British Journal of Cancer, vol. 80, no. 9, pp. 1445–1452, 1999
  63. The fast alternative cryogenic experiment testbed
    Cryogenics, vol. 39, no. 12, pp. 1029–1035, 1999
  64. Cancer Causes and Control, vol. 10, no. 5, pp. 369–377, 1999
  65. Evidence suggesting the role of specific genetic factors in cigarette smoking.
    Health Psychology, vol. 18, no. 1, Article ID 1998-03081-003, 6 pages, 1999
  66. Molecular epidemiology of human cancer risk: gene-environment interactions andp53 mutation spectrum in human lung cancer
    The Journal of Pathology, vol. 187, no. 1, pp. 8–18, 1999
  67. An evaluation of proposed frameworks for grouping polychlorinated biphenyl (PCB) congener data into meaningful analytic units
    American Journal of Industrial Medicine, vol. 35, no. 3, pp. 223–231, 1999
  68. Apolipoprotein E allelic frequency in elderly smokers
    American Journal of Medical Genetics, vol. 76, no. 1, pp. 32–36, 1998
  69. Breast cancer risk, meat consumption and N-acetyltransferase (NAT2) genetic polymorphisms
    International Journal of Cancer, vol. 75, no. 6, pp. 825–830, 1998
  70. Depression and self-medication with nicotine: The modifying influence of the dopamine D4 receptor gene.
    Health Psychology, vol. 17, no. 1, Article ID 1997-42831-007, 6 pages, 1998
  71. Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues
    European Journal of Cancer, vol. 34, no. 6, pp. 914–920, 1998
  72. p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer
    Pharmacogenetics, vol. 8, no. 6, pp. 503–512, 1998
  73. Helicobacter pylori infection and genetic polymorphisms for cancer-related genes in gastric carcinogenesis
    Biomedecine & Pharmacotherapy, vol. 51, no. 4, pp. 145–149, 1997
  74. Serum, plasma and paraffin-embedded tissues as sources of DNA for studying cancer susceptibility genes
    Carcinogenesis, vol. 18, no. 6, pp. 1271–1275, 1997
  75. Lack of association of tyrosine hydroxylase genetic polymorphism with cigarette smoking
    Pharmacogenetics, vol. 7, no. 6, pp. 521–524, 1997
  76. Chemicals and cancer
    European Journal of Cancer Prevention, vol. 5, no. 5, pp. 391–404, 1996
  77. Distribution of 7-alkyl-2'-deoxyguanosine adduct levels in human lung
    Carcinogenesis, vol. 17, no. 4, pp. 741–748, 1996
  78. Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk
    JAMA: The Journal of the American Medical Association, vol. 276, no. 18, pp. 1494–1501, 1996
  79. A cytochrome P4502E1 genetic polymorphism and tobacco smoking in breast cancer
    Molecular Carcinogenesis, vol. 17, no. 3, pp. 144–150, 1996
  80. Genetic polymorphisms of the cancer related gene andHelicobacter pylori infection in Japanese gastric cancer patients: An age and gender matched case–control study
    Cancer, vol. 77, no. 8, pp. 1654–1661, 1996
  81. The impact of glutathiones-transferase M1 and cytochrome P450 1A1 genotypes on white-blood-cell polycyclic aromatic hydrocarbon-dna adduct levels in humans
    Molecular Carcinogenesis, vol. 14, no. 1, pp. 63–68, 1995
  82. Cytochrome P45O2E1 (CYP2E1) genetic polymorphism in a case-control study of gastric cancer and liver disease
    Pharmacogenetics, vol. 5, no. Special Issue, pp. S141–S144, 1995
  83. Confined Space Hazards: Combined Exposure to Styrene, Fiberglass, and Silica
    Journal of Occupational and Environmental Medicine, vol. 37, no. 2, pp. 185–188, 1995
  84. The Association of Polymorphic N-Acetyltransferase (NAT2) with Breast Cancer Risk
    Annals of the New York Academy of Sciences, vol. 768, no. 1, pp. 250–252, 1995
  85. Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans
    Pharmacogenetics, vol. 4, no. 5, pp. 242–246, 1994
  86. Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens
    Nature, vol. 369, no. 6476, Article ID 369154a0, 2 pages, 1994
  87. Susceptibility markers in normal subjects: A pilot study for the investigation of 2,3,7,8-tetrachlorodibenzo-p-dioxin related diseases
    Chemosphere, vol. 27, no. 1-3, pp. 375–381, 1993
  88. Simian Virus 40 Large Tumor Antigen-Immortalized Normal Human Liver Epithelial Cells Express Hepatocyte Characteristics and Metabolize Chemical Carcinogens
    Proceedings of the National Academy of Sciences, vol. 90, no. 11, pp. 5123–5127, 1993
  89. Genotoxicity of heated cooking oil vapors
    Mutation Research/Genetic Toxicology, vol. 298, no. 2, pp. 105–111, 1992
  90. Molecular epidemiology and the genetics of environmental cancer
    JAMA: The Journal of the American Medical Association, vol. 266, no. 5, pp. 681–687, 1991
  91. Subchronic Administration of Caffeine and Theophylline in Drinking Water: Effects on Rat Liver Rna Polymerase Activity
    Drug and Chemical Toxicology, vol. 4, no. 2, pp. 89–100, 1981