John W. Baynes
Dr. John Baynes is Distinguished Professor Emeritus of Chemistry and Biochemistry at the University of South Carolina, and is currently Research Professor of Exercise Science in the School of Public Health. His research program addresses the role of chemical modifications of proteins in the pathogenesis of chronic disease, including diabetes and atherosclerosis. He is credited with the discovery of the advanced glycoxidation end-products (AGEs), carboxymethyllysine (CML) and carboxyethyllysine (CEL), and the demonstration that these compounds are formed during both carbohydrate and lipid autoxidation reactions, i.e. that they may be either AGEs or advanced lipoxidation end-products (ALEs). His work has focused attention on the complementary role of carbohydrates and lipids in chemical modification of proteins in aging and disease. Current research interests include: 1) studies on the use of chelators to inhibit diabetic complications, including nephropathy and cardiomyopathy; 2) succination of protein in diabetes; 3) the role of mitochondrial and oxidative stress in development of diabetes and its complications; and 4) mechanisms underlying endoplasmic reticulum stress in adipose tissue in diabetes.
Biography Updated on 2 August 2010