Donata Orioli was born in 1967 in Felonica , Italy. She obtained the M.S. degree in biological sciences from the University of Pavia (Italy) in 1991 and the Ph.D. degree (summa cum laude) at the European Molecular Biology Laboratory (EMBL) of Heidelberg (Germany) in 1997. From 2000 to 2008, she was a Research Fellow at the Institute of Molecular Genetics (IGM) of the Italian National Research Council (CNR) in Pavia. Since 2009, she has been a CNR Researcher and she is leading a research group at the IGM. Since 2005, she has been teaching at the University of Pavia. She has extensive experience in the fields of axon guidance and nervous system development in mouse models and neuronal cell cultures. Since 2003, her research activity has been focused on the role of genomic instability in neurodegeneration, aging and cancer, using as a model system cells derived from patients affected by hereditary disorders defective in nucleotide excision repair (NER), a versatile DNA repair system that removes a wide range of DNA lesions, including the major UV-induced photoproducts. Her current main research interest is the pathogenesis of trichothiodystrophy and Cockayne syndrome, two genetic disorders defective in functions operating at the crosstalk between NER and transcription.
Biography Updated on 13 July 2011