Isabelle Hautefort obtained her Ph.D. degree in 1998 from the University of Paris XI, at the Department of Ecology and Physiology of the Digestive Tract, INRA, Jouy-en-Josas (France). There, she studied the factors involved in the colonization of Gastrointestinal Tract by a commensal strain of Lactobacillus fermentum in relation to the colonization resistance exerted by the predominant microbiota against foreign bacteria. After finishing her Ph.D. degree, Hautefort was first recruited on a TMR European Fellowship at the Institute of Molecular Medicine, Oxford (UK), to work on gene expression of Salmonella enterica serovar Typhimurium during infection. She then moved to the Institute of Food Research (IFR) in Professor Jay Hinton’s group in 1999, to pursue her work on deciphering Salmonella gene expression during infection. She developed different infection models and genetic tools to detect and quantify the level of Salmonella gene expression in individual bacterial cells. Using postgenomic approaches, Hautefort also reported the first Salmonella transcriptomic profile inside infected human epithelial cells. Through her interest in understanding the interactions that occur between the host (in particular the GI tract epithelium and associated immune system) and food-borne pathogens, she joined the Gut Immunity group of Professor Simon Carding at IFR in 2009, where she is investigating the role of specific intestinal intraepithelial lymphocytes in various gut barrier functions and their role in the resistance to pathogen infection such as Salmonellosis.
Biography Updated on 9 August 2011