Michael S. Wolin
Michael S. Wolin's research has focused on elucidating fundamental concepts of vascular oxidant signaling mechanisms. He earned his Ph.D. degree in chemistry from Yale University, Conn, USA, in 1981, and his thesis work examined how adenylate cyclase synthesized cAMP. His subsequent postdoctoral work with Louis J. Ignarro at the Department of Pharmacology of Tulane University, New Orleans, La, USA, investigated how the soluble form of guanylate cyclase was regulated by nitric oxide, porphyrins, and free radicals. Dr. Wolin joined the Department of Physiology of New York Medical College as an Assistant Professor in 1983 and subsequently rose to the rank of Professor in 1995. He was an Established Investigator of the American Heart Association (AHA) and a recipient of a Merit Award from the NHLBI. Moreover, he gave the AHA Dickenson Richards Lecture in 2000. Dr. Wolin was a Member of the Research Committee and Scientific Sessions Program Committee of the AHA, a past Chair of the AHA Cardiopulmonary, Perioperative and Critical Care Council, a Member of the NIH VCMB study section, and an Associate Editor for the Journal Microcirculation and the American Journal of Physiology-Heart and Circulatory Physiology. He gave the Berne Distinguished Lecture at the Experimental Biology Meeting in 2008. His research has focused on how reactive oxygen species and their interactions with nitric oxide control vascular signaling mechanisms associated with endothelial function, mitochondrial respiration, and guanylate cyclase. Through collaborations at NYMC, he has been able to investigate how vascular oxidant and/or NO signaling mechanisms controls microcirculatory function and is altered by complications of pregnancy, exercise, heart failure, systemic and pulmonary hypertension, diabetes, and aging. More recent interests include understanding the regulatory role of cytosolic NAD(P)H redox and how these systems control of Nox oxidases and differences in oxygen sensing mechanisms between the coronary and pulmonary vasculature.
Biography Updated on 2 January 2013