Andrew W. Taylor, PhD, received his PhD in 1990 at the Ohio State University from the Department of Microbiology in the field of host defense mechanisms to wounds and infections. Postdoctoral training was completed in 1993 with Scott Cousins, MD and the late J. Wayne Streilein, MD at the University of Miami School of Medicine. He then joined the faculty of the Schepens Eye Research Institute and the Department of Ophthalmology, Harvard Medical School. In April 2010, Dr. Taylor joined the faculty of the Department of Ophthalmology, and the Immunology Training program of the Boston University School of Medicine. Our analysis of aqueous humor and retinal pigment epithelial cells has identified an important role for several neuropeptides in suppressing inflammation, while promoting immune tolerance, and non-inflammatory host defense mechanisms. The hypothesis of this research program is that the ocular microenvironment suppresses inflammation and manipulates immunity to regulate itself to the benefit of maintaining vision; and that the immunosuppression is the result of localized production of immunomodulation neuropeptides to maintain immune homeostasis within the ocular microenvironment. With this focus, we are analyzing ocular immunobiology to understand the role of neuropeptides in regulating adaptive and innate immunity within the eye, the mechanisms that promote alternative activation of retinal microglia and macrophages in the retina, the mechanisms that promote natural, untreated recovery from autoimmune disease in mouse models of uveitis, the mechanism of immunomodulation mediated by the melanocortin pathway through the neuropeptide alpha-Melanocyte Stimulating Hormone a central mediator of ocular immunoregulation, and how to use the mechanisms of ocular immunoregulation and immunosuppression to suppress autoimmune disease, transplantation graft rejection, and hypersensitivity.
Biography Updated on 19 April 2011