Paul W. Doetsch

Paul W. Doetsch is a Professor of Biochemistry, Radiation Oncology and Hematology & Oncology and is the Emory University School of Medicine Distinguished Chair in Cancer Research; Since 2005, he has served as Deputy Director for Basic Research at the Emory - Winship Cancer Institute. Dr. Doetsch received his B.S. degree in biochemistry from the University of Maryland and the M.S. degree in medicinal chemistry from Purdue University. He obtained his doctoral training in nucleic acids biochemistry in the laboratory of Dr. Robert Suhadolnik at Temple University School of Medicine. Dr. Doetsch conducted postdoctoral work as at the Dana Farber Cancer Institute, Harvard Medical School in the laboratory of Dr. William Haseltine. Dr. Doetsch has been a faculty member engaged in basic cancer research at Emory since 1985. Dr. Doetsch has served in the past as a regular member of the Radiation Study Section at the NIH and the Carcinogenesis, Nutrition and Environment study section of the American Cancer Society. He is internationally recognized for his studies and publications in the areas of DNA damage repair, mutagenesis and genetic instability. Over a decade ago, he discovered transcriptional mutagenesis and has been a pioneer in this area and its leading authority. He is the coeditor of a recent (2006) textbook, DNA Damage Recognition and has trained dozens of Ph.D. students and postdoctoral fellows.

Biography Updated on 4 December 2007

Articles in Scholarly Journals [Incomplete List]

  1. Chemical Reviews, vol. 106, no. 2, pp. 474–488, 2006
  2. Journal of the American Chemical Society, vol. 127, no. 45, pp. 15833–15842, 2005
  3. Oxidative DNA Damage Causes Mitochondrial Genomic Instability in Saccharomyces cerevisiae
    Molecular and Cellular Biology, vol. 25, no. 12, pp. 5196–5204, 2005
  4. Differential involvement of the related DNA helicases Pif1p and Rrm3p in mtDNA point mutagenesis and stability
    Gene, vol. 354, pp. 86–92, 2005
  5. Involvement of two endonuclease III homologs in the base excision repair pathway for the processing of DNA alkylation damage in Saccharomyces cerevisiae
    DNA Repair, vol. 3, no. 1, pp. 51–59, 2004
  6. Biological consequences of oxidative stress-induced DNA damage in Saccharomyces cerevisiae
    Nucleic Acids Research, vol. 32, no. 12, pp. 3712–3723, 2004
  7. DNA Damage-Processing Pathways Involved in the Eukaryotic Cellular Response to Anticancer DNA Cross-Linking Drugs
    Molecular Pharmacology, vol. 65, no. 6, pp. 1496–1506, 2004
  8. Spontaneous DNA Damage in Saccharomyces cerevisiae Elicits Phenotypic Properties Similar to Cancer Cells
    Journal of Biological Chemistry, vol. 279, no. 21, pp. 22585–22594, 2004
  9. Characterization of AP lyase activities of Saccharomyces cerevisiae Ntg1p and Ntg2p: implications for biological function
    Nucleic Acids Research, vol. 31, no. 19, pp. 5560–5567, 2003
  10. Transcriptional Mutagenesis Induced by Uracil and 8-Oxoguanine in Escherichia coli
    Molecular Cell, vol. 12, no. 4, pp. 959–970, 2003
  11. Translesion synthesis by RNA polymerases: occurrence and biological implications for transcriptional mutagenesis
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 510, no. 1-2, pp. 131–140, 2002
  12. Mitochondrial Dysfunction Due to Oxidative Mitochondrial DNA Damage Is Reduced through Cooperative Actions of Diverse Proteins
    Molecular and Cellular Biology, vol. 22, no. 12, pp. 4086–4093, 2002
  13. Enzymatic processing of DNA containing tandem dihydrouracil by endonucleases III and VIII
    Nucleic Acids Research, vol. 29, no. 2, pp. 407–414, 2001
  14. Deletion of the MAG1 DNA glycosylase gene suppresses alkylation-induced killing and mutagenesis in yeast cells lacking AP endonucleases
    Mutation Research/DNA Repair, vol. 487, no. 3-4, pp. 137–147, 2001
  15. Ntg2 of Saccharomyces cerevisiae Repairs the Oxidation Products of 8-Hydroxyguanine
    Biochemical and Biophysical Research Communications, vol. 285, no. 5, pp. 1186–1191, 2001
  16. EDITORIAL
    Methods, vol. 22, no. 2, p. 115, 2000
  17. In Vivo Technique for Determining Transcriptional Mutagenesis
    Methods, vol. 22, no. 2, pp. 120–126, 2000
  18. Biochemistry, vol. 39, no. 19, pp. 5788–5796, 2000
  19. The nature of the 5'-terminus is a major determinant for DNA processing by Schizosaccharomyces pombe Rad2p, a FEN-1 family nuclease
    Nucleic Acids Research, vol. 28, no. 15, pp. 2893–2901, 2000
  20. Biochemistry, vol. 39, no. 10, pp. 2659–2666, 2000
  21. Biochemistry, vol. 38, no. 35, pp. 11298–11306, 1999
  22. Inorganic Chemistry, vol. 38, no. 26, pp. 6069–6080, 1999
  23. Journal of the American Chemical Society, vol. 121, no. 45, pp. 10652–10653, 1999
  24. Substrate specificity of ultraviolet DNA endonuclease (UVDE/Uve1p) from Schizosaccharomyces pombe
    Nucleic Acids Research, vol. 27, no. 11, pp. 2256–2264, 1999
  25. E. coli RNA Polymerase Bypass of DNA Base Damage: Mutagenesis at the Level of Transcription
    Annals of the New York Academy of Sciences, vol. 870, no. 1 MOLECULAR STR, pp. 386–388, 1999
  26. Phenotypic Change Caused by Transcriptional Bypass of Uracil in Nondividing Cells
    Science, vol. 284, no. 5411, pp. 159–162, 1999
  27. Base Excision Repair of Oxidative DNA Damage Activated by XPG Protein
    Molecular Cell, vol. 3, no. 1, pp. 33–42, 1999
  28. Mutation identification DNA analysis system (MIDAS) for detection of known mutations
    Electrophoresis, vol. 20, no. 6, pp. 1141–1148, 1999
  29. Effects of Nonbulky DNA Base Damages on Escherichia coli RNA Polymerase-mediated Elongation and Promoter Clearance
    Journal of Biological Chemistry, vol. 273, no. 33, pp. 21276–21281, 1998
  30. Characterization of Schizosaccharomyces pombe Rad2 protein, a FEN-1 homolog
    Nucleic Acids Research, vol. 26, no. 16, pp. 3645–3650, 1998
  31. Substrate specificities of the ntg1 and ntg2 proteins of Saccharomyces cerevisiae for oxidized DNA bases are not identical
    Nucleic Acids Research, vol. 26, no. 23, pp. 5270–5276, 1998
  32. Escherichia coli RNA and DNA polymerase bypass of dihydrouracil: mutagenic potential via transcription and replication
    Nucleic Acids Research, vol. 26, no. 7, pp. 1707–1712, 1998
  33. Biochemistry, vol. 37, no. 17, pp. 6033–6040, 1998
  34. Biochemistry, vol. 37, no. 33, pp. 11599–11604, 1998
  35. Biochemistry, vol. 36, no. 4, pp. 721–729, 1997
  36. Biochemistry, vol. 35, no. 47, pp. 14999–15008, 1996
  37. T7 RNA polymerase bypass of large gaps on the template strand reveals a critical role of the nontemplate strand in elongation
    Cell, vol. 82, no. 4, pp. 577–585, 1995
  38. A novel activity of E. coli uracil DNA N-glycosylase excision of isodialuric acid (5,6-dihydroxyuracil), a major product of oxidative DNA damage, from DNA
    FEBS Letters, vol. 364, no. 3, pp. 255–258, 1995
  39. Biochemistry, vol. 34, no. 3, pp. 737–742, 1995
  40. What's old is new: an alternative DNA excision repair pathway
    Trends in Biochemical Sciences, vol. 20, no. 10, pp. 384–386, 1995
  41. Biochemistry, vol. 33, no. 49, pp. 14926–14934, 1994
  42. Molecular modeling Studies of a Deoxyoctanucleotide Containing a Dihydrouridine Lesion
    Annals of the New York Academy of Sciences, vol. 726, no. 1 DNA Damage, pp. 299–302, 1994
  43. Efficient Bypass and Base Misinsertions at Abasic Sites by Prokaryotic RNA Polymerases
    Annals of the New York Academy of Sciences, vol. 726, no. 1 DNA Damage, pp. 351–354, 1994
  44. Journal of the American Chemical Society, vol. 115, no. 12, pp. 5105–5110, 1993
  45. Effects of Abasic Sites and DNA Single-Strand Breaks on Prokaryotic RNA Polymerases
    Proceedings of the National Academy of Sciences, vol. 90, no. 14, pp. 6601–6605, 1993
  46. A eukaryotic DNA glycosylase/lyase recognizing ultraviolet light-induced pyrimidine dimers
    Nature, vol. 356, no. 6371, Article ID 356725a0, 3 pages, 1992
  47. Bleomycin A2 and B2 Purification by Flash Chromatography for Chemical and Biochemical Studies
    Preparative Biochemistry and Biotechnology, vol. 21, no. 4, pp. 257–268, 1991
  48. Biochemistry, vol. 30, no. 40, pp. 9749–9756, 1991
  49. The enzymology of apurinic/apyrimidinic endonucleases
    Mutation Research/DNA Repair, vol. 236, no. 2-3, pp. 173–201, 1990
  50. Identification of a Mammalian Nuclear Factor and Human cDNA-Encoded Proteins that Recognize DNA Containing Apurinic Sites
    Proceedings of the National Academy of Sciences, vol. 87, no. 9, pp. 3396–3400, 1990
  51. Partial purification and characterization of an endonuclease from spinach that cleaves ultraviolet light-damaged duplex DNA
    Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 1007, no. 3, pp. 309–317, 1989
  52. Biochemistry, vol. 27, no. 7, pp. 2629–2634, 1988
  53. Wavelength Dependence for Human Redoxy-Endonuclease-Mediated DNA Cleavage at Sites of UV-Induced Photoproducts
    Radiation Research, vol. 113, no. 3, p. 543, 1988
  54. Thymine glycol-DNA glycosylase/AP endonuclease of CEM-C1 lymphoblasts: A human analog of endonuclease III
    Biochemical and Biophysical Research Communications, vol. 149, no. 1, pp. 93–101, 1987
  55. Biochemistry, vol. 25, no. 8, pp. 2205–2211, 1986
  56. Biochemistry, vol. 25, no. 8, pp. 2212–2220, 1986
  57. Biochemistry, vol. 24, no. 21, pp. 5723–5728, 1985
  58. Construction of a plasmid containing functional , , and genes in a configuration potentially suitable for mammalian expression
    Plasmid, vol. 11, no. 3, pp. 253–259, 1984
  59. Biochemistry, vol. 22, no. 17, pp. 4153–4158, 1983
  60. 2',5'-Adenylate and Cordycepin Trimer Cores: Metabolic Stability and Evidence for Antimitogenesis without 5'-Rephosphorylation
    Nucleosides, Nucleotides and Nucleic Acids, vol. 2, no. 4, pp. 351–366, 1983
  61. Inhibition of Epstein-Barr virus-associated nuclear antigen (EBNA) induction by (2',5')oligoadenylate and the cordycepin analog: Mechanism of action for inhibition of EBV-induced transformation
    Virology, vol. 122, no. 1, pp. 198–201, 1982
  62. Core (2'-5')oligoadenylate and the Cordycepin Analog: Inhibitors of Epstein--Barr Virus-Induced Transformation of Human Lymphocytes in the Absence of Interferon
    Proceedings of the National Academy of Sciences, vol. 78, no. 11, pp. 6699–6703, 1981
  63. Synthesis and characterization of (2'-5')ppp3'dA(p3'dA)n, an analogue of (2'-5')pppA(pA)n
    Nature, vol. 291, no. 5813, Article ID 291355a0, 3 pages, 1981
  64. Cactus alkaloids XL. Identification of mescaline and other ß-phenethylamines in Pereskia, Pereskiopsis and Islaya by use of fluorescamine conjugates
    Journal of Chromatography A, vol. 189, no. 1, pp. 79–85, 1980