Kevin D. Bunting
Kevin D. Bunting received his Ph.D. degree in biochemistry in 1995 from the Wake Forest University,Winston-Salem, NC, USA and did postdoctoral training at St. Jude Children’s Research Hospital, Memphis, Tenn, USA, in the fields of experimental hematology, hematopoiesis, stem cell biology, and gene therapy. While at St. Jude, he developed an interest in cytokine signaling pathways controlling lymphocyte development (common gamma chain/JAK3) and an interest in how signaling pathways modulate hematopoietic stem cell functions (STAT5). Since 1999, Dr. Bunting has used STAT5-deficient mouse models to explore the role of STAT5 activation in cytokine signaling important for survival, proliferation, and differentiation decisions in early hematopoiesis. His work has shown major roles for STAT5 in the competitive fitness of hematopoietic stem cells. The Bunting laboratory is currently exploring the mechanisms by which STAT5 regulates quiescence, self-renewal in hematopoietic stem cells, and testing novel approaches for nonmyeloablative transplantation. Dr. Bunting also coleads the Stem Cells and Hematologic Malignancies Program of the Case Comprehensive Cancer Center which aims to link the basic biology of hematopoietic stem cells and immune cells with therapeutic stem cell transplant and hematologic malignancy clinical trials.
Biography Updated on 28 September 2010