C. David Pauza

C. David Pauza received the Ph.D. degree in 1981 from the University of California, Berkeley. From 1981 to 1985, Dr. Pauza was a Postdoctoral Fellow and Staff Member of the Laboratory of Molecular Biology at the Medical Research Council, Cambridge, England. In 1985, Dr. Pauza moved to the Salk Institute for Biological Studies in La Jolla, California, where he started the AIDS Research Program and guided its development until 1990 when he accepted an appointment at the University of Wisconsin-Madison. Moving from Assistant to Full Professor in 6 years, Dr. Pauza created the Immunology and Virology Division at the Wisconsin National Primate Center and established strong interdisciplinary programs in AIDS involving basic, clinical, and animal models research. After 10 years at the University of Wisconsin, Dr. Pauza moved to the Institute of Human Virology as Professor in the Basic Science Division and, since 2004, as an Assistant Director. Dr. Pauza is also appointed as a Professor (tenure) in the Department of Medicine and an Adjunct Professor in Department of Microbiology and Immunology. In addition to more than 20 years in laboratory, animal model, and clinical studies on HIV/AIDS, Dr. Pauza is active in international research programs. He is a Consultant in immunology for the Chinese Integrated Program for Research on AIDS, a Collaborator to the Plateau State University in Jos, Nigeria, and a Member of the Scientific Board for the Chantal Biya Center for International Research in Yaounde, Cameroon. Since 1984, Dr. Pauza has been committed to basic research and education in support of the fight against AIDS. He continues this work at the Institute of Human Virology, by developing domestic and international programs to address fundamental challenges to the prevention and treatment of HIV/AIDS.

Biography Updated on 31 May 2007

Personal Home Page

www.ihv.org

Articles in Scholarly Journals [Incomplete List]

  1. Innate-like ?d T cell responses to mycobacterium Bacille Calmette-Guerin using the public V?2 repertoire in Macaca fascicularis
    Tuberculosis, vol. 87, no. 4, pp. 373–383, 2007
  2. Attenuated Disease in SIV-Infected Macaques Treated with a Monoclonal Antibody against FasL
    Clinical and Developmental Immunology, vol. 2007, Article ID 93462, 9 pages, 2007
  3. HIV Tat Protein Increases Bcl-2 Expression in Monocytes Which Inhibits Monocyte Apoptosis Induced by Tumor Necrosis Factor-Alpha-Related Apoptosis-Induced Ligand
    Intervirology, vol. 50, no. 3, pp. 224–228, 2007
  4. Gamma Interferon Secretion by Human V 2V 2 T Cells after Stimulation with Antibody against the T-Cell Receptor plus the Toll-Like Receptor 2 Agonist Pam3Cys
    Infection and Immunity, vol. 74, no. 8, pp. 4505–4511, 2006
  5. Vaccinia Virus Inhibits T Cell Receptor-Dependent Responses by Human ?d T Cells
    The Journal of Infectious Diseases, vol. 195, no. 1, pp. 37–45, 2006
  6. Individual V?2-J?1.2+ T cells respond to both isopentenyl pyrophosphate and Daudi cell stimulation: generating tumor effectors with low molecular weight phosphoantigens
    Cancer Immunology, Immunotherapy, vol. 56, no. 6, pp. 819–829, 2006
  7. A Plea for Justice for Jailed Medical Workers
    Science, vol. 314, no. 5801, pp. 924–925, 2006
  8. Human V 2V 2 T cells contain cytoplasmic RANTES
    International Immunology, vol. 18, no. 8, pp. 1243–1251, 2006
  9. Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions
    Cell Research, vol. 15, no. 11-12, Article ID 7290370, 11 pages, 2005
  10. The Proline-Rich Homeodomain (PRH/HEX) Protein Is Down-Regulated in Liver during Infection with Lymphocytic Choriomeningitis Virus
    Journal of Virology, vol. 79, no. 4, pp. 2461–2473, 2005
  11. The Vgamma2/Vdelta2 T-cell repertoire in Macaca fascicularis: functional responses to phosphoantigen stimulation by the Vgamma2/Jgamma1.2 subset
    Immunology, vol. 115, no. 2, pp. 197–205, 2005
  12. Sequence Variation within the Dominant Amino Terminus Epitope Affects Antibody Binding and Neutralization of Human Immunodeficiency Virus Type 1 Tat Protein
    Journal of Virology, vol. 78, no. 23, pp. 13190–13196, 2004
  13. Furin cleavage of the HIV-1 Tat protein
    FEBS Letters, vol. 565, no. 1-3, pp. 89–92, 2004
  14. Association between Longer Duration of HIV-Suppressive Therapy and Partial Recovery of the V2 T Cell Receptor Repertoire
    The Journal of Infectious Diseases, vol. 189, no. 8, pp. 1482–1486, 2004
  15. Mucosal arenavirus infection of primates can protect them from lethal hemorrhagic fever
    Journal of Medical Virology, vol. 72, no. 3, pp. 424–435, 2004
  16. Whole-body positron emission tomography in patients with HIV-1 infection
    The Lancet, vol. 362, no. 9388, pp. 959–961, 2003
  17. HIV-Mediated T Cell Depletion Is Specific for V2+ Cells Expressing the J1.2 Segment
    AIDS Research and Human Retroviruses, vol. 19, no. 1, pp. 21–29, 2003
  18. Monocytes Treated with Human Immunodeficiency Virus Tat Kill Uninfected CD4+ Cells by a Tumor Necrosis Factor-Related Apoptosis-Induced Ligand-Mediated Mechanism
    Journal of Virology, vol. 77, no. 12, pp. 6700–6708, 2003
  19. Tat-Neutralizing Antibodies in Vaccinated Macaques
    Journal of Virology, vol. 77, no. 5, pp. 3157–3166, 2003
  20. Vgamma9Vdelta2 T-Cell Anergy and Complementarity-Determining Region 3-Specific Depletion during Paroxysm of Nonendemic Malaria Infection
    Infection and Immunity, vol. 71, no. 5, pp. 2945–2949, 2003
  21. Innate T-Cell Immunity in HIV Infections: The Role of Vg9Vd2 T Lymphocytes
    Current Molecular Medicine, vol. 2, no. 8, pp. 769–781, 2002
  22. CXCR4-dependent HIV-1 infection of differentiated epithelial cells
    Virus Research, vol. 90, no. 1-2, pp. 275–286, 2002
  23. Biochemistry, vol. 40, no. 42, pp. 12486–12496, 2001
  24. Down-regulation of CXCR1 and CXCR2 expression on human neutrophils upon activation of whole blood by S. aureus is mediated by TNF-alpha
    Clinical and Experimental Immunology, vol. 125, no. 3, pp. 414–422, 2001
  25. STAPHYLOCOCCAL SUPERANTIGENS INDUCE LYMPHOTACTIN PRODUCTION BY HUMAN CD4+ AND CD8+ T CELLS
    Cytokine, vol. 16, no. 2, pp. 73–78, 2001
  26. In vitro stimulation with a non-peptidic alkylphosphate expands cells expressing Vgamma2-Jgamma1.2/Vdelta2 T-cell receptors
    Immunology, vol. 104, no. 1, pp. 19–27, 2001
  27. Blood-brain barrier disruption in simian immunodeficiency virus encephalitis
    Neuropathology and Applied Neurobiology, vol. 26, no. 5, pp. 454–462, 2000
  28. Whole Body Positron Emission Tomography Imaging of Activated Lymphoid Tissues during Acute Simian–Human Immunodeficiency Virus 89.6PD Infection in Rhesus Macaques
    Virology, vol. 274, no. 2, pp. 255–261, 2000
  29. Importance of the CD3 marker for evaluating changes in rhesus macaque CD4/CD8 T-cell ratios
    Cytometry, vol. 40, no. 1, pp. 69–75, 2000
  30. Murine immune responses to mucosally delivered Salmonella expressing Lassa fever virus nucleoprotein
    Vaccine, vol. 18, no. 15, pp. 1543–1554, 2000
  31. Vaccination with Tat toxoid attenuates disease in simian/HIV-challenged macaques
    Proceedings of the National Academy of Sciences, vol. 97, no. 7, pp. 3515–3519, 2000
  32. Definition of Five New Simian Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitopes and Their Restricting Major Histocompatibility Complex Class I Molecules: Evidence for an Influence on Disease Progression
    Journal of Virology, vol. 74, no. 16, pp. 7400–7410, 2000
  33. Rapid and slow progressors differ by a single MHC class I haplotype in a family of MHC-defined rhesus macaques infected with SIV
    Immunology Letters, vol. 66, no. 1-3, pp. 53–59, 1999
  34. Nature Medicine, vol. 5, no. 11, pp. 1270–1276, 1999
  35. Recombinant, attenuated Salmonella typhimurium stimulate lymphoproliferative responses to SIV capsid antigen in rhesus macaques
    Vaccine, vol. 17, no. 7-8, pp. 923–932, 1999
  36. Gag Protein from Human Immunodeficiency Virus Type 1 Assembles in the Absence of Cyclophilin A
    Virology, vol. 252, no. 1, pp. 228–234, 1998
  37. Cyclophilin A Modulates Processing of Human Immunodeficiency Virus Type 1 p55Gag: Mechanism for Antiviral Effects of Cyclosporin A
    Virology, vol. 245, no. 2, pp. 197–202, 1998
  38. Whole body positron emission tomography imaging of simian immunodeficiency virus-infected rhesus macaques
    Proceedings of the National Academy of Sciences, vol. 93, no. 13, pp. 6425–6430, 1996
  39. Persistent non-B cell lymphocytosis in HIV-infected individuals
    Immunology Letters, vol. 48, no. 2, pp. 157–158, 1995
  40. 2-LTR Circular Viral DNA as a Marker for Human Immunodeficiency Virus Type 1 Infection in Vivo
    Virology, vol. 205, no. 2, pp. 470–478, 1994
  41. Human Immunodeficiency Virus Infection of Human Brain Capillary Endothelia Cells Occurs via a CD4/Galactosylceramide-Independent Mechanism
    Proceedings of the National Academy of Sciences, vol. 90, no. 22, pp. 10474–10478, 1993
  42. Rethinking the AIDS conundrum
    Cellular Immunology, vol. 144, no. 2, pp. 465–466, 1992
  43. Extrachromosomal human immunodeficiency virus type 1 sequences are methylated in latently infected U937 cells
    Virology, vol. 188, no. 2, pp. 451–458, 1992
  44. Two bases are deleted from the termini of HIV-1 linear DNA during integrative recombination
    Virology, vol. 179, no. 2, pp. 886–889, 1990
  45. Reinfection results in accumulation of unintegrated viral DNA in cytopathic and persistent human immunodeficiency virus type 1 infection of CEM cells
    Journal of Experimental Medicine, vol. 172, no. 4, pp. 1035–1042, 1990
  46. Human immunodeficiency virus infection of T cells and monocytes proceeds via receptor-mediated endocytosis
    The Journal of Cell Biology, vol. 107, no. 3, pp. 959–968, 1988
  47. HIV persistence in monocytes leads to pathogenesis and AIDS1
    Cellular Immunology, vol. 112, no. 2, pp. 414–424, 1988
  48. The control of transferrin receptor synthesis in mitogen-stimulated human lymphocytes*1
    Experimental Cell Research, vol. 154, no. 2, pp. 510–520, 1984
  49. Location of Amino Acid Alterations in Mutants of Aspartate Transcarbamoylase: Structural Aspects of Interallelic Complementation
    Proceedings of the National Academy of Sciences, vol. 81, no. 1, pp. 115–119, 1984
  50. Genes Encoding Escherichia coli Aspartate Transcarbamoylase: The pyrB-pyrI Operon
    Proceedings of the National Academy of Sciences, vol. 79, no. 13, pp. 4020–4024, 1982