Ryichi Kikkawa

Articles in Scholarly Journals [Incomplete List]

  1. Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus
    Journal of Human Genetics, vol. 50, no. 6, pp. 283–292, 2005
  2. Genetic Variations in the Gene Encoding ELMO1 Are Associated With Susceptibility to Diabetic Nephropathy
    Diabetes, vol. 54, no. 4, pp. 1171–1178, 2005
  3. Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration-Site Family Member 5B (WNT5B) with Type 2 Diabetes
    The American Journal of Human Genetics, vol. 75, no. 5, pp. 832–843, 2004
  4. BMC Nephrology, vol. 5, no. 1, p. 18, 2004
  5. Antiproteinuric effect of candesartan cilexetil in Japanese subjects with type 2 diabetes and nephropathy
    Diabetes Research and Clinical Practice, vol. 66, no. 1, pp. 87–95, 2004
  6. A simple and sensitive method for glutamine:fructose-6-phosphate amidotransferase assay
    Journal of Biochemical and Biophysical Methods, vol. 59, no. 3, pp. 201–208, 2004
  7. Diabetic neuropathy and nerve regeneration
    Progress in Neurobiology, vol. 69, no. 4, pp. 229–285, 2003
  8. Overview of Glucose Signaling in Mesangial Cells in Diabetic Nephropathy
    Journal of the American Society of Nephrology, vol. 14, no. 5, pp. 1374–1382, 2003
  9. APOE Polymorphism and the Progression of Diabetic Nephropathy in Japanese Subjects With Type 2 Diabetes: Results of a prospective observational follow-up study
    Diabetes Care, vol. 26, no. 8, pp. 2416–2420, 2003
  10. Association of Solute Carrier Family 12 (Sodium/Chloride) Member 3 With Diabetic Nephropathy, Identified by Genome-Wide Analyses of Single Nucleotide Polymorphisms
    Diabetes, vol. 52, no. 11, pp. 2848–2853, 2003
  11. Antiproteinuric effect of candesartan cilexetil in patients with chronic glomerulonephritis.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, vol. 3, no. 3, p. 167, 2002
  12. 15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells
    Kidney International, vol. 61, no. 6, pp. 1957–1967, 2002
  13. Combined Expression of Pancreatic Duodenal Homeobox 1 and Islet Factor 1 Induces Immature Enterocytes to Produce Insulin
    Diabetes, vol. 51, no. 5, pp. 1398–1408, 2002
  14. Effect of captopril or imidapril on the progression of diabetic nephropathy in Japanese with type 1 diabetes mellitus: a randomized controlled study (JAPAN-IDDM)
    Diabetes Research and Clinical Practice, vol. 55, no. 2, pp. 113–121, 2002
  15. Corrigendum to “Effect of captopril or imidapril on the progression of diabetic nephropathy in Japanese with type 1 diabetes mellitus: a randomized controlled study (JAPAN-IDDM)” [Diabetes Res. Clin. Pract. 55 (2002) 113–121]
    Diabetes Research and Clinical Practice, vol. 57, no. 1, p. 71, 2002
  16. Cyclic AMP inhibits stretch-induced overexpression of fibronectin in glomerular mesangial cells
    European Journal of Pharmacology, vol. 437, no. 3, pp. 113–122, 2002
  17. Enhancement of glomerular heme oxygenase-1 expression in diabetic rats
    Diabetes Research and Clinical Practice, vol. 52, no. 2, pp. 85–96, 2001
  18. Nifedipine and enalapril equally reduce the progression of nephropathy in hypertensive type 2 diabetics
    Diabetes Research and Clinical Practice, vol. 54, no. 3, pp. 191–201, 2001
  19. Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress
    Journal of the American College of Cardiology, vol. 38, no. 7, pp. 1821–1828, 2001
  20. Protein-tyrosine Phosphatase-1B Negatively Regulates Insulin Signaling in L6 Myocytes and Fao Hepatoma Cells
    Journal of Biological Chemistry, vol. 276, no. 13, pp. 10207–10211, 2001
  21. Insulin-Induced c-Jun N-Terminal Kinase Activation Is Negatively Regulated by Protein Kinase C  
    Endocrinology, vol. 142, no. 6, pp. 2669–2676, 2001
  22. Insulin Production in a Neuroectodermal Tumor that Expresses Islet Factor-1, But Not Pancreatic-Duodenal Homeobox 1
    Journal of Clinical Endocrinology & Metabolism, vol. 86, no. 4, pp. 1795–1800, 2001
  23. Dinucleotide repeat polymorphism of matrix metalloproteinase-9 gene is associated with diabetic nephropathy
    Kidney International, vol. 60, no. 4, pp. 1428–1434, 2001
  24. Expression of Rho-family GTPases (Rac, cdc42, RhoA) and their association with p-21 activated kinase in adult rat peripheral nerve
    Journal of Neurochemistry, vol. 77, no. 4, pp. 986–993, 2001
  25. Clinical Efficacy of Fidarestat, a Novel Aldose Reductase Inhibitor, for Diabetic Peripheral Neuropathy: A 52-week multicenter placebo-controlled double-blind parallel group study
    Diabetes Care, vol. 24, no. 10, pp. 1776–1782, 2001
  26. Increased Arterial Wall Stiffness Limits Flow Volume in the Lower Extremities in Type 2 Diabetic Patients
    Diabetes Care, vol. 24, no. 12, pp. 2107–2114, 2001
  27. Peptide and Protein Library Screening Defines Optimal Substrate Motifs for AKT/PKB
    Journal of Biological Chemistry, vol. 275, no. 46, pp. 36108–36115, 2000
  28. Effective Dose Equivalent on the Ninth Shuttle–Mir Mission (STS-91)
    Radiation Research, vol. 154, no. 6, p. 705, 2000
  29. Significance of Glomerular Deposition of C3c and C3d in IgA Nephropathy
    American Journal of Nephrology, vol. 20, no. 2, pp. 122–128, 2000
  30. Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats
    Diabetes, vol. 49, no. 6, pp. 1022–1032, 2000
  31. Persistent Activation of Phosphatidylinositol 3-Kinase Causes Insulin Resistance Due to Accelerated Insulin-Induced Insulin Receptor Substrate-1 Degradation in 3T3-L1 Adipocytes
    Endocrinology, vol. 141, no. 6, pp. 1930–1935, 2000
  32. Immunohistochemical characterization of glomerular PDGF B-chain and PDGF ß-receptor expression in diabetic rats
    Diabetes Research and Clinical Practice, vol. 48, no. 2, pp. 87–98, 2000
  33. IDL can stimulate atherogenic gene expression in cultured human vascular endothelial cells
    Diabetes Research and Clinical Practice, vol. 48, no. 2, pp. 127–138, 2000
  34. Evaluation of endothelial free radical release by vascular tension responses in insulin-resistant rat aorta
    European Journal of Pharmacology, vol. 394, no. 2-3, pp. 295–299, 2000
  35. Evaluation of diabetic neuropathy through the quantitation of cutaneous nerves
    Journal of the Neurological Sciences, vol. 172, no. 1, pp. 55–62, 2000
  36. Usefulness of waveform analysis of popliteal artery in Type II diabetic patients using gated magnetic resonance 2D-cine-PC imaging and 31 P spectroscopy
    Diabetologia, vol. 43, no. 8, pp. 1031–1038, 2000
  37. 1 H- and 31 P-magnetic resonance spectroscopy and imaging as a new diagnostic tool to evaluate neuropathic foot ulcers in Type II diabetic patients
    Diabetologia, vol. 43, no. 2, pp. 165–172, 2000
  38. A new antidiabetic agent (JTT-501) rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle
    Diabetologia, vol. 42, no. 2, pp. 151–159, 1999
  39. Insulin-like growth factor I stimulates glucose uptake and expression of glucose transporter 1 in cultured mesangial cells
    Clinical and Experimental Nephrology, vol. 3, no. 3, pp. 159–162, 1999
  40. Effect of glycemic control on plasma plant sterol levels and post-heparin diamine oxidase activity in type 1 diabetic patients
    Atherosclerosis, vol. 145, no. 2, pp. 389–397, 1999
  41. Mitogen-activated protein kinase phosphatase: a negative regulator of the mitogen-activated protein kinase cascade
    European Journal of Pharmacology, vol. 365, no. 1, pp. 1–7, 1999
  42. Effects of cholesterol-lowering treatments on oxidative modification of plasma intermediate density lipoprotein plus low density lipoprotein fraction in Type 2 diabetic patients
    Diabetes Research and Clinical Practice, vol. 43, no. 2, pp. 111–120, 1999
  43. Free radical production in endothelial cells as a pathogenetic factor for vascular dysfunction in the insulin resistance state
    Diabetes Research and Clinical Practice, vol. 45, no. 2-3, pp. 199–203, 1999
  44. Tetrodotoxin-resistant sodium channels of dorsal root ganglion neurons are readily activated in diabetic rats
    Neuroscience, vol. 90, no. 3, pp. 933–939, 1999
  45. Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta
    Diabetes, vol. 48, no. 12, pp. 2437–2445, 1999
  46. Diabetic nephropathy is not associated with the dinucleotide repeat polymorphism upstream of the aldose reductase (ALR2) gene but with erythrocyte aldose reductase content in Japanese subjects with type 2 diabetes
    Diabetes, vol. 48, no. 2, pp. 420–422, 1999
  47. Stretch-induced overproduction of fibronectin in mesangial cells is mediated by the activation of mitogen-activated protein kinase
    Diabetes, vol. 48, no. 3, pp. 595–602, 1999
  48. The 3'-untranslated region polymorphism of the gene for skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in the type 2 diabetic Japanese population
    Diabetes, vol. 48, no. 7, pp. 1469–1472, 1999
  49. Relationship between Polymorphism in the Angiotensinogen, Angiotensin-Converting Enzyme or Angiotensin II Receptor and Renal Progression in Japanese NIDDM Patients
    Nephron, vol. 82, no. 2, pp. 139–144, 1999
  50. Expression of a Dominant Negative SHP-2 in Transgenic Mice Induces Insulin Resistance
    Journal of Biological Chemistry, vol. 274, no. 42, pp. 30236–30243, 1999
  51. TGF-beta1 stimulates glucose uptake by enhancing GLUT1 expression in mesangial cells
    Kidney International, vol. 55, no. 5, pp. 1704–1712, 1999
  52. Atrial natriuretic peptide inhibits endothelin-1-induced activation of JNK in glomerular mesangial cells
    Kidney International, vol. 53, no. 5, pp. 1133–1142, 1998
  53. Nephropathy in type II diabetes - epidemiological issues as viewed from Japan
    Nephrology Dialysis Transplantation, vol. 13, no. 11, pp. 2743–2745, 1998
  54. Altered activities of transcription factors and their related gene expression in cardiac tissues of diabetic rats
    Diabetes, vol. 47, no. 8, pp. 1318–1325, 1998
  55. Neuronal and glial expression of heparin-binding EGF-like growth factor in central nervous system of prenatal and early postnatal rat
    Developmental Brain Research, vol. 108, no. 1-2, pp. 263–272, 1998
  56. Delayed Wallerian degeneration and increased neurofilament phosphorylation in sciatic nerves of rats with streptozocin-induced diabetes
    Journal of the Neurological Sciences, vol. 155, no. 1, pp. 23–30, 1998
  57. Increased intestinal glucose absorption and postprandial hyperglycaemia at the early step of glucose intolerance in Otsuka Long-Evans Tokushima Fatty Rats
    Diabetologia, vol. 41, no. 12, pp. 1459–1466, 1998
  58. Oxidized lipoproteins found in patients with NIDDM stimulate radical-induced monocyte chemoattractant protein-1 mRNA expression in cultured human endothelial cells
    Diabetologia, vol. 40, no. 6, pp. 662–670, 1997
  59. Beraprost sodium, an analogue of prostacyclin, induces the expression of mitogen-activated protein kinase phosphatase and inhibits the proliferation of cultured mesangial cells
    European Journal of Pharmacology, vol. 336, no. 2-3, pp. 291–294, 1997
  60. Microalbuminuria is not associated with cardiovascular death in Japanese NIDDM
    Diabetes Research and Clinical Practice, vol. 35, no. 1, pp. 35–40, 1997
  61. Distribution of heparin-binding EGF-like growth factor protein and mRNA in the normal rat kidneys
    Kidney International, vol. 51, no. 6, Article ID ki1997244, 5 pages, 1997
  62. Endothelin-1 activates c-Jun NH2-terminal kinase in mesangial cells
    Kidney International, vol. 51, no. 3, Article ID ki199792, 8 pages, 1997
  63. Atrial Natriuretic Peptide Induces the Expression of MKP-1, a Mitogen-activated Protein Kinase Phosphatase, in Glomerular Mesangial Cells
    Journal of Biological Chemistry, vol. 271, no. 1, pp. 544–547, 1996
  64. Expression of Dominant Negative Mutant SHPTP2 Attenuates Phosphatidylinositol 3`-Kinase Activity via Modulation of Phosphorylation of Insulin Receptor Substrate-1
    Journal of Biological Chemistry, vol. 271, no. 21, pp. 12595–12602, 1996
  65. Differential inhibition of mesangial MAP kinase cascade by cyclic nucleotides
    Kidney International, vol. 50, no. 2, Article ID ki1996327, 7 pages, 1996
  66. Tolrestat improves nerve regeneration after crush injury in streptozocin-induced diabetic rats*1
    Metabolism, vol. 45, no. 10, pp. 1189–1195, 1996
  67. Clinical investigation of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy in Japan: Multicenter study
    Journal of Diabetes and its Complications, vol. 10, no. 3, pp. 168–172, 1996
  68. SHPTP2 Serves Adapter Protein Linking between Janus Kinase 2 and Insulin Receptor Substrates
    Biochemical and Biophysical Research Communications, vol. 228, no. 1, pp. 122–127, 1996
  69. Antibodies against GM1 ganglioside affect K+ and NA+ currents in isolated rat myelinated nerve fibers
    Annals of Neurology, vol. 37, no. 4, pp. 436–442, 1995
  70. Prevention of glomerular hyperfiltration in rats with streptozotocin-induced diabetes by an atrial natriuretic peptide receptor antagonist
    Diabetologia, vol. 38, no. 5, pp. 536–542, 1995
  71. Increase of voltage-sensitive calcium channels and calcium accumulation in skeletal muscles of streptozocin-induced diabetic rats
    Metabolism, vol. 44, no. 11, pp. 1455–1461, 1995
  72. Significance of fructose-induced protein oxidation and formation of advanced glycation end product
    Journal of Diabetes and its Complications, vol. 9, no. 2, pp. 87–91, 1995
  73. Thiazolidine Derivatives Ameliorate High Glucose-induced Insulin Resistance via the Normalization of Protein-tyrosine Phosphatase Activities
    Journal of Biological Chemistry, vol. 270, no. 13, pp. 7724–7730, 1995
  74. Metabolic effect of PGE1 analogue 01206.aCD on nerve Na+-K+-ATPase activity of rats with streptozocin-induced diabetes is mediated via cAMP: Possible role of cAMP in diabetic neuropathy
    Prostaglandins, vol. 47, no. 5, pp. 367–378, 1994
  75. The effect of an aldose reductase inhibitor (Epalrestat) on diabetic nephropathy in rats
    Diabetes Research and Clinical Practice, vol. 25, no. 3, pp. 147–154, 1994
  76. Diabetic nephropathy in Japan
    Diabetes Research and Clinical Practice, vol. 24, pp. S191–S197, 1994
  77. Insulin Receptor Kinase Phosphorylates Protein Tyrosine Phosphatase Containing Src Homology 2 Regions and Modulates Its PTPase Activity in Vitro
    Biochemical and Biophysical Research Communications, vol. 199, no. 2, pp. 780–785, 1994
  78. High Glucose Condition Activates Protein Tyrosine Phosphatases and Deactivates Insulin Receptor Function in Insulin-Sensitive Rat 1 Fibroblasts
    Biochemical and Biophysical Research Communications, vol. 201, no. 1, pp. 71–77, 1994
  79. Current status of Type 2 (non-insulin-dependent) diabetic subjects on dialysis therapy in Japan
    Diabetologia, vol. 36, no. 10, pp. 1105–1108, 1993
  80. Biological Receptors Mediate Anti-proliferative Action of Atrial Natriuretic Peptide in Cultured Mesangial Cells
    Biochemical and Biophysical Research Communications, vol. 192, no. 2, pp. 642–648, 1993
  81. Antagonist for Atrial Natriuretic Peptide Receptors Ameliorates Glomerular Hyperfiltration in Diabetic Rats
    Biochemical and Biophysical Research Communications, vol. 193, no. 2, pp. 700–705, 1993
  82. Src Homology 2 Domains of Protein Tyrosine Phosphatase Are Phosphorylated by Insulin Receptor Kinase and Bind to the COOH-Terminus of Insulin Receptors in Vitro
    Biochemical and Biophysical Research Communications, vol. 194, no. 1, pp. 208–214, 1993
  83. Atrial Natriuretic Peptide Inhibits Endothelin-1-Induced Activation of Mitogen-Activated Protein Kinase in Cultured Rat Mesangial Cells
    Biochemical and Biophysical Research Communications, vol. 195, no. 1, pp. 72–78, 1993
  84. Pioglitazone Ameliorates High Glucose Induced Desensitization of Insulin Receptor Kinase in Rat 1 Fibroblasts in Culture
    Biochemical and Biophysical Research Communications, vol. 197, no. 3, pp. 1078–1082, 1993
  85. Differential modulation of mitogenic and metabolic actions of insulin-like growth factor I in rat glomerular mesangial cells in high glucose culture
    Diabetologia, vol. 36, no. 4, pp. 276–281, 1993
  86. Effect of medium pH on glutathione redox cycle in cultured human umbilical vein endothelial cells
    Metabolism, vol. 42, no. 9, pp. 1121–1126, 1993
  87. An animal model of chronic ischemic neuropathy with proliferative changes of nerve microvessel wall
    Journal of the Neurological Sciences, vol. 120, no. 1, pp. 64–70, 1993
  88. Electrophysiological study of dorsal column function in streptozocin-induced diabetic rats: comparison with 2,5-hexanedione intoxication
    Journal of the Neurological Sciences, vol. 115, no. 1, pp. 58–66, 1993
  89. Effects of verapamil on the cardiac a1-adrenoceptor signalling system in diabetic rats
    European Journal of Pharmacology: Molecular Pharmacology, vol. 244, no. 2, pp. 105–109, 1993
  90. Nipradilol inhibits rat mesangial cell mitogenesis through the activation of soluble guanylate cyclase
    European Journal of Pharmacology: Molecular Pharmacology, vol. 245, no. 1, pp. 79–82, 1993
  91. Alteration of mesangial response to ANP and angiotensin II by glucose
    Kidney International, vol. 44, no. 3, Article ID ki1993276, 8 pages, 1993
  92. High blood pressure is a risk factor for the development of microalbuminuria in Japanese subjects with non-insulin-dependent diabetes mellitus
    Journal of Diabetes and its Complications, vol. 6, no. 3, pp. 181–185, 1992
  93. Increased plasma post-heparin diamine oxidase activity and plant sterol levels in streptozotocin diabetic rat
    Biochemical and Biophysical Research Communications, vol. 186, no. 1, pp. 398–404, 1992
  94. Dual mechanism of angiotensin II inhibits ANP-induced mesangial cGMP accumulation
    Kidney International, vol. 40, no. 2, Article ID ki1991199, 6 pages, 1991
  95. Mesangial cell dysfunction
    Journal of Diabetic Complications, vol. 5, no. 2-3, pp. 58–59, 1991
  96. Clinical significance of microalbuminuria in Japanese subjects with non-insulin-dependent diabetes
    Journal of Diabetic Complications, vol. 5, no. 2-3, pp. 84–86, 1991
  97. Insulin-like growth factor I (IGF-I) stimulates glucose and amino acid uptake in cultured glomerular mesangial cells
    Journal of Diabetic Complications, vol. 5, no. 2-3, pp. 184–185, 1991
  98. Glucose-induced overproduction of type IV collagen in cultured glomerular mesangial cells
    Journal of Diabetic Complications, vol. 5, no. 2-3, pp. 199–200, 1991
  99. Glucose enhances type IV collagen production in cultured rat glomerular mesangial cells
    Diabetologia, vol. 34, no. 3, pp. 198–200, 1991
  100. Microalbuminuria associated with a rise in blood pressure in non-insulin-dependent diabetes
    Journal of Diabetic Complications, vol. 3, no. 2, pp. 99–102, 1989
  101. Chronically streptozocin-diabetic monkey does not closely mimic human diabetic neuropathy
    Experimental Neurology, vol. 104, no. 2, pp. 133–137, 1989
  102. A new prostaglandin E1 analogue (TFC-612) prevents a decrease in motor nerve conduction velocity in streptozocin-diabetic rats
    Biochemical and Biophysical Research Communications, vol. 150, no. 1, pp. 225–230, 1988
  103. Thyrotropin-Releasing Hormone Reduces myo-Inositol Content in Rat Cerebellum Pretreated with Lithium
    Journal of Neurochemistry, vol. 49, no. 1, pp. 88–91, 1987
  104. Impaired contractile responsiveness of diabetic glomeruli to angiotensin II: A possible indication of mesangial dysfunction in diabetes mellitus
    Biochemical and Biophysical Research Communications, vol. 136, no. 3, pp. 1185–1190, 1986
  105. Effect of angiotensin II infusion on glomerular angiotensin II receptor in rats
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol. 885, no. 3, pp. 309–316, 1986
  106. The effect of cyproheptadine on insulin biosynthesis
    Experientia, vol. 41, no. 1, pp. 80–82, 1985
  107. Prevention of peripheral nerve dysfunction by an aldose reductase inhibitor in streptozotocin-diabetic rats
    Metabolism, vol. 33, no. 3, pp. 212–214, 1984
  108. Temperature-dependent negative cooperativity among angiotensin II receptors of isolated rat glomeruli
    Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 800, no. 1, pp. 66–74, 1984
  109. The effects of cyproheptadine on glucose tolerance and pancreatic islets in rats
    Acta Diabetologica Latina, vol. 18, no. 2, pp. 107–114, 1981
  110. β-Naphthyl-azo-polystyrene-insulin as a means of protecting insulin molecule from digestive enzymes
    Biochemical and Biophysical Research Communications, vol. 44, no. 1, pp. 51–56, 1971