Tracey Petryshen works as an Assistant Professor of Psychiatry at Harvard Medical School and Massachusetts General Hospital in Boston, Mass ,USA. She obtained her Ph.D. degree in medical science (specialty in medical genetics) for thesis work on genetic linkage studies of dyslexia. She completed postdoctoral training in psychiatric genetics at the Broad Institute, where she currently serves as the Head of the Behavioral Neurogenetics Program within the Stanley Center for Psychiatric Research. The focus of Dr. Petryshen's research is the etiology and treatment of multifactorial psychiatric and behavioral disorders through patient and mouse neurogenetic studies, and mouse behavioral pharmacology studies. Dr. Petryshen has led numerous studies to identify and characterize candidate genes for schizophrenia and bipolar disorder encompassing linkage, haplotype-based gene association, population genetic, and microarray mRNA expression methods. She is currently focusing on investigating the role of psychiatric risk genes in regulating brain function through genetic association studies of intermediate phenotypes (endophenotypes) in patient populations. Her translational human and mouse research encompasses examining risk genes identified in patient genetic studies using in vivo mouse brain RNA interference and transgenic models to investigate the effect of gene expression changes at both the phenotypic and cellular levels. In addition, her lab utilizes mouse behavioral, biochemical, and molecular methods to investigate the mechanisms of clinical medications and the therapeutic potential of novel small molecules targeting biochemical pathways and epigenetic mechanisms implicated in psychiatric illness.
Biography Updated on 2 November 2012