David Reisman obtained his B.S. degree and his M.S. degree from the University of Illinois, Urbana, Ill, USA, in plant virology and geminiviruses and his Ph.D. (1986) from the University of Wisconsin, Madison, Wis, USA, in the replication of Epstein–Barr virus. He was a Postdoctoral Fellow at the Weizmann Institute of Science, Rehovot, Israel (1986–1990), studying the regulation of expression of the p53 tumor suppressor gene. He also served as a Research Scientist (1990–1991) at the Department of Chemistry and Biochemistry, the University of Colorado Boulder, Boulder, Colo, USA, and as a Professor at the Department of Biological Sciences, the University of South Carolina, Columbia, SC, USA. The overall focus of his research has been to define mechanisms that are responsible for cell cycle-regulated transcription of the p53 tumor suppressor gene in normal cells as well as aberrant transcription of p53 in tumor cells. Over the years, he has identified a series of new regulatory sites on both the murine and human p53 promoters, cloned additional regions from the murine genome that are essential for cell cycle-regulated transcription, evaluated the role of promoter mutations in the loss of p53 transcription in myeloid leukemias, identified factors responsible for the loss of p53 transcription in some breast cancers, and identified factors that contribute to cell cycle regulation of p53 transcription.
Biography Updated on 11 April 2012